KR890016978A - Synthetic resin matrix combined with wound healing enhancer - Google Patents

Synthetic resin matrix combined with wound healing enhancer Download PDF

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Publication number
KR890016978A
KR890016978A KR1019890007108A KR890007108A KR890016978A KR 890016978 A KR890016978 A KR 890016978A KR 1019890007108 A KR1019890007108 A KR 1019890007108A KR 890007108 A KR890007108 A KR 890007108A KR 890016978 A KR890016978 A KR 890016978A
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KR
South Korea
Prior art keywords
alkyl
alkoxy
methacrylate
enhancer
acrylate
Prior art date
Application number
KR1019890007108A
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Korean (ko)
Inventor
코롤 버나드
나탄 포올
Original Assignee
원본미기재
엔 퀘이 파마슈티칼 아쏘시에쓰
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Priority claimed from US07/199,375 external-priority patent/US4857334A/en
Application filed by 원본미기재, 엔 퀘이 파마슈티칼 아쏘시에쓰 filed Critical 원본미기재
Publication of KR890016978A publication Critical patent/KR890016978A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음No content

Description

상처치료 강화제를 결합시킨 합성수지 기질계Synthetic resin matrix combined with wound healing enhancer

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제 1 도는 중합체 피복성분으로 표피성장 인자를 함유하는 본 발명의 상처치료 또는 다른형의 드레싱을 나타내는 투시도, 제 2 도는 투명의 두 받침 시이트 사이에 있는 본 발명의 상처치료용 드레싱의 투시도.1 is a perspective view showing a wound treatment or other type of dressing of the present invention containing an epidermal growth factor as a polymer coating component, and FIG. 2 is a perspective view of a wound dressing of the present invention between two transparent support sheets.

Claims (6)

미립자상의, 친수성이고, 물에 팽창되는 중합체와, 불활성, 비독성이며 물에 혼화되는 유기용제와, 수소결합 가소제와, 그리고 치료강화제를 포함하고 있는 약제를 저장하고 장기간에 걸쳐서 방출시키는 상처치료 강화제를 결합시킨 합성수지 기질계에 있어서, 상기 중합체는 히드록시(C2-C4알킬)메타크릴레이트, 히드록시(C2-C4알킬)아크릴레이트, 히드록시(C2-C4알콕시 C2-C4알킬)메타크릴레이트, 히드록시(C2-C4알콕시 C2-C4알킬)아크릴레이트, 알콕시(C|2-C4알콕시 C2-C4알킬)메타크릴레이트, 알콕시(C2-C4알콕시 C2-C4알킬)아크릴레이트, N-(C1-C4알킬)아크릴아미드, N-(C1-C4알킬)메타크릴레이트, N,N-디(C1-C4알킬)아크릴아미드, N,N-디(C1-C4알킬)메타크릴아미드, 비시날-에폭시(C1-C4알킬)메타크릴레이트 또는 비시날-에폭시(C1-C4알킬)아크릴레이트에서 선택한 것이고, 상기용매는 약 200-2000그람 분자량 단위의 평균분자량을 갖는 폴리에틸렌 글리콜 또는 폴리프로필렌 글리콜이며, 상기 가소제는 디메틸술폭시드, 디메틸프탈레이트, 2,3-부틸렌 카보네이트, 디메틸포름아미드, 디메틸테트라메틸렌 술폰, 디에틸 술폰, 메틸렌 글리콜레이트, 메틸프로필 술폰 또는 부티로락톤에서 선택한 것이고, 상기 중합체는 상기 기질계의 약 15-50 중량%의 범위내에 있으며, 상기 용제는 상기 기질계의 약 30-65중량%의 범위내에 있으며, 상기 가소제는 상기 기질계의 약 20중량% 이상의 범위내에 있으며, 그리고 성장인자 또는 치료강화제인 국부 또는 전체 치료용 의약제로 이루어짐을 특징으로 하는 상처치료 강화제를 결합시킨 합성수지 기질계.Wound reinforcement agents for storing and releasing prolonged medicaments containing particulate, hydrophilic, water-expandable polymers, inert, non-toxic, water-miscible organic solvents, hydrogen bond plasticizers, and therapeutic enhancers In the synthetic resin matrix system, the polymer is hydroxy (C 2 -C 4 alkyl) methacrylate, hydroxy (C 2 -C 4 alkyl) acrylate, hydroxy (C 2 -C 4 alkoxy C 2 -C 4 alkyl) methacrylate, hydroxy (C 2 -C 4 alkoxy C 2 -C 4 alkyl) acrylate, alkoxy (C | 2 -C 4 alkoxy C 2 -C 4 alkyl) methacrylate, alkoxy ( C 2 -C 4 alkoxy C 2 -C 4 alkyl) acrylate, N- (C 1 -C 4 alkyl) acrylamide, N- (C 1 -C 4 alkyl) methacrylate, N, N-di (C 1- C 4 alkyl) acrylamide, N, N-di (C 1 -C 4 alkyl) methacrylamide, bisinal-epoxy (C 1 -C 4 alkyl) methacrylate or bisinal-epoxy (C 1 -C 4 alkyl) acrylate, the solvent is polyethylene glycol or polypropylene glycol having an average molecular weight of about 200-2000 grams of molecular weight units, and the plasticizer is dimethyl sulfoxide, dimethylphthalate, 2,3-butylene Carbonate, dimethylformamide, dimethyltetramethylene sulfone, diethyl sulfone, methylene glycolate, methylpropyl sulfone or butyrolactone, the polymer is in the range of about 15-50% by weight of the substrate system, the solvent Is in the range of about 30-65% by weight of the matrix system, and the plasticizer is in the range of about 20% by weight or more of the matrix system, and is composed of a local or total therapeutic drug which is a growth factor or a therapeutic enhancer. Synthetic resin matrix system combined with a wound healing enhancer. 제 1 항에 있어서, 치료강화제 표피성장인자(EGF)임을 특징으로 하는것.The method of claim 1, wherein the therapeutic enhancer is epidermal growth factor (EGF). 제 2 항에 있어서, EGF가, 53-아미노산을 함유하고 약 5,000그람 분자량 단위의 분자량을 갖는 폴리펜티드로 이루어진 인체유도물질(hEGF)과 동등함을 특징으로 하는것.3. The method of claim 2 wherein the EGF is equivalent to a human derived substance (hEGF) consisting of polypentide containing 53-amino acid and having a molecular weight of about 5,000 gram molecular weight units. 제 3 항에 있어서, 한쌍의 받침시이트를 갖고, 치료 강화제를 갖는 기질계가 상기 시이트의 중간체로 배열됨을 특징으로 하는것.4. The substrate system according to claim 3, wherein the substrate system having a pair of support sheets and the therapeutic enhancer is arranged in the intermediate of the sheet. 제 4 항에 있어서, 상기 시이트들이 투명임을 특징으로 하는것.5. The method of claim 4 wherein the sheets are transparent. 제 4 항에 있어서, 상기 받침시이트중 하나가 탄성을 가짐을 특징으로 하는것.5. The method of claim 4, wherein one of said support sheets is elastic. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890007108A 1988-05-27 1989-05-27 Synthetic resin matrix combined with wound healing enhancer KR890016978A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/199375 1988-05-27
US07/199,375 US4857334A (en) 1983-10-17 1988-05-27 Synthetic resin matrix system incorporating healing enhancer

Publications (1)

Publication Number Publication Date
KR890016978A true KR890016978A (en) 1989-12-14

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Application Number Title Priority Date Filing Date
KR1019890007108A KR890016978A (en) 1988-05-27 1989-05-27 Synthetic resin matrix combined with wound healing enhancer

Country Status (5)

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JP (1) JPH0267215A (en)
KR (1) KR890016978A (en)
AU (1) AU3518489A (en)
IL (1) IL90399A0 (en)
ZA (1) ZA893986B (en)

Also Published As

Publication number Publication date
ZA893986B (en) 1991-01-30
IL90399A0 (en) 1990-01-18
AU3518489A (en) 1989-11-30
JPH0267215A (en) 1990-03-07

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