JPH0267215A - Synthetic resin matrix containing healing enhancer - Google Patents
Synthetic resin matrix containing healing enhancerInfo
- Publication number
- JPH0267215A JPH0267215A JP1131704A JP13170489A JPH0267215A JP H0267215 A JPH0267215 A JP H0267215A JP 1131704 A JP1131704 A JP 1131704A JP 13170489 A JP13170489 A JP 13170489A JP H0267215 A JPH0267215 A JP H0267215A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- matrix system
- synthetic resin
- resin matrix
- plasticizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011159 matrix material Substances 0.000 title claims abstract 15
- 229920003002 synthetic resin Polymers 0.000 title claims abstract 9
- 239000000057 synthetic resin Substances 0.000 title claims abstract 9
- 230000035876 healing Effects 0.000 title claims 4
- 239000003623 enhancer Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 13
- 229920000642 polymer Polymers 0.000 claims abstract 7
- 239000004014 plasticizer Substances 0.000 claims abstract 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000003960 organic solvent Substances 0.000 claims abstract 3
- 239000002904 solvent Substances 0.000 claims abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 2
- 230000010261 cell growth Effects 0.000 claims abstract 2
- 239000003102 growth factor Substances 0.000 claims abstract 2
- 231100000252 nontoxic Toxicity 0.000 claims abstract 2
- 230000003000 nontoxic effect Effects 0.000 claims abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 3
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 2
- 229940116977 epidermal growth factor Drugs 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 claims 2
- 239000004593 Epoxy Substances 0.000 claims 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- MBDUIEKYVPVZJH-UHFFFAOYSA-N 1-ethylsulfonylethane Chemical compound CCS(=O)(=O)CC MBDUIEKYVPVZJH-UHFFFAOYSA-N 0.000 claims 1
- QAPSIUMUNHNUPW-UHFFFAOYSA-N 1-methylsulfonylpropane Chemical compound CCCS(C)(=O)=O QAPSIUMUNHNUPW-UHFFFAOYSA-N 0.000 claims 1
- KBLZUSCEBGBILB-UHFFFAOYSA-N 2,2-dimethylthiolane 1,1-dioxide Chemical compound CC1(C)CCCS1(=O)=O KBLZUSCEBGBILB-UHFFFAOYSA-N 0.000 claims 1
- LWLOKSXSAUHTJO-UHFFFAOYSA-N 4,5-dimethyl-1,3-dioxolan-2-one Chemical compound CC1OC(=O)OC1C LWLOKSXSAUHTJO-UHFFFAOYSA-N 0.000 claims 1
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 1
- 102400001368 Epidermal growth factor Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229930188620 butyrolactone Natural products 0.000 claims 1
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 claims 1
- 229960001826 dimethylphthalate Drugs 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- -1 methylene glycolate Chemical compound 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 2
- 239000012907 medicinal substance Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain a synthetic resin matrix system comprising a specific polymer, an organic solvent and a plasticizer, compounded with a cure-promoting medicine, and useful for storing the medicinal substance or releasing the medicinal substance for a long period. CONSTITUTION: This synthetic resin matrix system is obtained by compounding a matrix comprising a particulate, hydrophilic and water-swelling polymer [e.g. a hydroxy(2-4C alkyl) methacrylate polymer], an inactive nontoxic water- immiscible organic solvent (e.g. polyethylene glycol) and a hydrogen-bound plasticizer (e.g. dimethyl sulfoxide) with an epithelial cell growth factor or a cure-promoting medicine together with a treating article component. The matrix system comprises 15-50wt.% of the polymer, 30-65wt.% of the solvent and <=20wt.% of the plasticizer. The matrix system is molded between a pair of transparent backing sheets to give a wound-treating article.
Description
【発明の詳細な説明】
このような変更及び変更態様は本発明の精神の範囲内で
あれば、特許請求の範囲内に含む意図である。それで、
記述した好ましい実施態様の説明は主に例示するために
のみ行う。DETAILED DESCRIPTION OF THE INVENTION Such changes and modifications are intended to be included within the scope of the following claims if they are within the spirit of the invention. So,
The description of the preferred embodiments described is provided primarily by way of example only.
４、 の ’ｊＵ １
第１図は上皮細胞増殖因子をポリマーコーティング中の
成分として、損傷した表面、例えばヒト或は動物の皮膚
の表面に適用する通りに加入し、裏当てシートが手当用
品材料をおおう本発明の手当用品の予備成形した創傷或
はその他のタイプの斜視図であり、裏当てシートを一部
引きはがした状態で示す。4.'jU 1 Figure 1 shows that epidermal growth factor is incorporated as a component in a polymeric coating as applied to an injured surface, such as that of human or animal skin, and that the backing sheet is used as a dressing material. 1 is a perspective view of a preformed wound or other type of dressing of the present invention covering a wound, with the backing sheet partially removed; FIG.
第２図は創傷手当用品及び裏当てシートを創傷観察を容
易にするように、透明性を有する２つの裏当てシートの
間に入れた本発明の予備成形した創傷手当用品の斜視図
である。FIG. 2 is a perspective view of a preformed wound dressing of the present invention with the wound dressing and backing sheet placed between two transparent backing sheets to facilitate wound observation.
３：支持材 ５：手当用品コーティング ７．１３．１５：裏当てシート １１：パッド3: Support material 5: Handlings coating 7.13.15: Backing sheet 11: Pad
Claims (1)
性の水混和性有機溶媒と、水素結合可塑剤とを含む医薬
物質貯蔵及び長い期間の医薬物質放出用合成樹脂マトリ
ックス系であって、該ポリマーはヒドロキシ（Ｃ＿２−
Ｃ＿４アルキル）メタクリレート、ヒドロキシ（Ｃ＿２
−Ｃ＿４アルキル）アクリレート、ヒドロキシ（Ｃ＿２
−Ｃ＿４アルコキシＣ＿２−Ｃ＿４アルキル）メタクリ
レート、ヒドロキシ（Ｃ＿２−Ｃ＿４アルコキシＣ＿２
−Ｃ＿４アルキル）アクリレート、アルコキシ（Ｃ＿２
−Ｃ＿４アルコキシＣ＿２−Ｃ＿４アルキル）メタクリ
レート、アルコキシ（Ｃ＿２−Ｃ＿４アルコキシＣ＿２
−Ｃ＿４アルキル）アクリレート、Ｎ−（Ｃ＿１−Ｃ＿
４アルキル）アクリルアミド、Ｎ−（Ｃ＿１−Ｃ＿４ア
ルキル）メタクリルアミド、Ｎ，Ｎ−ジ（Ｃ＿１−Ｃ＿
４アルキル）アクリルアミド、Ｎ，Ｎ−ジ（Ｃ＿１−Ｃ
＿４アルキル）メタクリルアミド、ビシナル−エポキシ
（Ｃ＿１−Ｃ＿４アルキル）メタクリレート或はビシナ
ル−エポキシ（Ｃ＿１−Ｃ＿４アルキル）アクリレート
から成る群より選び、該溶媒は平均２００〜２０００グ
ラム分子量単位の分子量を有するポリエチレングリコー
ル或はポリプロピレングリコールから成る群より選び、
該可塑剤はジメチルスルホキシド、ジメチルフタレート
、２，３−ブチレンカーボネート、ジメチルホルムアミ
ド、ジメチルテトラメチレンスルホン、ジエチルスルホ
ン、メチレングリコレート、メチルプロピルスルホン或
はブチロラクトンから成る群より選び、該ポリマーは該
マトリックス系の１５〜５０重量％の範囲であり、該溶
媒は該マトリックス系の３０〜６５重量％の範囲であり
、該可塑剤は該マトリックスの２０重量％までの範囲で
あり、及び更に局部或は全身系治療作用のための薬剤を
含み、該薬剤は細胞増殖因子或は治癒増進剤を含む前記
系。 ２、前記治癒増進剤が上皮細胞増殖因子 （ＥＧＦ）である特許請求の範囲第１項記載の合成樹脂
マトリックス系。 ３、前記ＥＧＦが５３アミノ酸を含有し、およそ５，０
００グラム分子量単位の分子量を有するポリペプチドを
含むヒト由来の物質（ｈＥＧＦ）に等しい特許請求の範
囲第２項記載の合成樹脂マトリックス系。 ４、一対の裏当てシートを含み、治癒増進剤を有する該
マトリックス系を該シートの間に配置した特許請求の範
囲第３項記載の合成樹脂マトリックス系。 ５、前記シートが透明である特許請求の範囲第４項記載
の合成樹脂マトリックス系。 ６、前記裏当てシートの内の１つが弾性である特許請求
の範囲第４項記載の合成樹脂マトリックス系。[Claims] 1. For storage and long-term release of pharmaceutical substances, comprising a particulate hydrophilic, water-swellable polymer, an inert, non-toxic, water-miscible organic solvent, and a hydrogen-bonding plasticizer. It is a synthetic resin matrix system, and the polymer is hydroxy (C_2-
C_4 alkyl) methacrylate, hydroxy(C_2
-C_4 alkyl) acrylate, hydroxy(C_2
-C_4 alkoxyC_2-C_4 alkyl) methacrylate, hydroxy(C_2-C_4 alkoxyC_2
-C_4 alkyl) acrylate, alkoxy(C_2
-C_4 alkoxy C_2-C_4 alkyl) methacrylate, alkoxy (C_2-C_4 alkoxy C_2
-C_4 alkyl) acrylate, N-(C_1-C_
4 alkyl) acrylamide, N-(C_1-C_4 alkyl) methacrylamide, N,N-di(C_1-C_
4 alkyl) acrylamide, N,N-di(C_1-C
_4 alkyl) methacrylamide, vicinal epoxy (C_1-C_4 alkyl) methacrylate or vicinal epoxy (C_1-C_4 alkyl) acrylate, the solvent being a polyethylene glycol having an average molecular weight of 200 to 2000 gram molecular weight units. or selected from the group consisting of polypropylene glycol,
The plasticizer is selected from the group consisting of dimethyl sulfoxide, dimethyl phthalate, 2,3-butylene carbonate, dimethyl formamide, dimethyltetramethylene sulfone, diethyl sulfone, methylene glycolate, methylpropylsulfone or butyrolactone, and the polymer is the solvent ranges from 30 to 65% by weight of the matrix system, the plasticizer ranges from up to 20% by weight of the matrix, and further local or systemic A system comprising an agent for therapeutic action, said agent comprising a cell growth factor or a healing promoting agent. 2. The synthetic resin matrix system according to claim 1, wherein the healing promoting agent is epidermal growth factor (EGF). 3. The EGF contains 53 amino acids, approximately 5,0
Synthetic resin matrix system according to claim 2, which is equivalent to a substance of human origin (hEGF) containing a polypeptide with a molecular weight of 0.000 gram molecular weight units. 4. A synthetic resin matrix system according to claim 3, comprising a pair of backing sheets, between which said matrix system having a healing promoting agent is disposed. 5. The synthetic resin matrix system according to claim 4, wherein the sheet is transparent. 6. The synthetic resin matrix system of claim 4, wherein one of the backing sheets is elastic.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/199,375 US4857334A (en) | 1983-10-17 | 1988-05-27 | Synthetic resin matrix system incorporating healing enhancer |
| US199375 | 1988-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0267215A true JPH0267215A (en) | 1990-03-07 |
Family
ID=22737245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1131704A Pending JPH0267215A (en) | 1988-05-27 | 1989-05-26 | Synthetic resin matrix containing healing enhancer |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPH0267215A (en) |
| KR (1) | KR890016978A (en) |
| AU (1) | AU3518489A (en) |
| IL (1) | IL90399A0 (en) |
| ZA (1) | ZA893986B (en) |
-
1989
- 1989-05-25 IL IL90399A patent/IL90399A0/en unknown
- 1989-05-25 ZA ZA893986A patent/ZA893986B/en unknown
- 1989-05-26 AU AU35184/89A patent/AU3518489A/en not_active Abandoned
- 1989-05-26 JP JP1131704A patent/JPH0267215A/en active Pending
- 1989-05-27 KR KR1019890007108A patent/KR890016978A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3518489A (en) | 1989-11-30 |
| IL90399A0 (en) | 1990-01-18 |
| KR890016978A (en) | 1989-12-14 |
| ZA893986B (en) | 1991-01-30 |
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