KR890003798A - Reduction Method of Methionine Sulfoxide Residue - Google Patents

Reduction Method of Methionine Sulfoxide Residue Download PDF

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Publication number
KR890003798A
KR890003798A KR1019880010521A KR880010521A KR890003798A KR 890003798 A KR890003798 A KR 890003798A KR 1019880010521 A KR1019880010521 A KR 1019880010521A KR 880010521 A KR880010521 A KR 880010521A KR 890003798 A KR890003798 A KR 890003798A
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KR
South Korea
Prior art keywords
acid
concentration
present
sulfide
methionine sulfoxide
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Application number
KR1019880010521A
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Korean (ko)
Inventor
데니스 디마치 리차드
비얼 롱 핼런
Original Assignee
메리 앤 터커
일라이 릴리 앤드 캄파니
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Application filed by 메리 앤 터커, 일라이 릴리 앤드 캄파니 filed Critical 메리 앤 터커
Publication of KR890003798A publication Critical patent/KR890003798A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/122—Hydrolysis with acids different from HF

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

메티오닌 설폭사이드 잔기의 환원 방법Reduction Method of Methionine Sulfoxide Residue

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (9)

하나 또는 그 이상의 메티오닌 설폭사이드 잔기를 함유하는 팹타이드 또는 단백질을, 약 0.01M내지 약 3M의 유기 설파이드 및 염산, 브롬화수소산, 및 요오드화 수소산으로 구성된 그룹이로 부터 선택된 약 0.01M 내지 약 3M의 할로산을 함유하는 실질적으로 무수 상태인 트리플루오로 아세트산 반응매질로 처리함을 특징으로 하여, 하나 또는 그 이상의 메티오닌 설폭사이드 잔기를 함유하는 팹타이드 또는 단백질을 처리하여 이들 잔기를 메오닌 잔기로 환원시키는 방법.A fabtide or protein containing one or more methionine sulfoxide moieties is about 0.01 M to about 3 M halo selected from the group consisting of about 0.01 M to about 3 M organic sulfides and hydrochloric acid, hydrobromic acid, and hydroiodic acid Treatment with a phthalide or a protein containing one or more methionine sulfoxide residues to reduce these residues to methione residues, characterized by treatment with a substantially anhydrous trifluoro acetic acid reaction medium containing an acid. Way. 제 1 항에 있어서, 단백질 또는 팹타이드가 약 0.01 내지 약 100㎎/㎖의 농도로 존재하는 방법.The method of claim 1, wherein the protein or fabtide is present at a concentration of about 0.01 to about 100 mg / ml. 제 2 항에 있어서, 단백질 또는 팹타이드가 약 0.1 내지 약 20㎎/㎖의 농도로 존재하는 방법.The method of claim 2 wherein the protein or fabtide is present at a concentration of about 0.1 to about 20 mg / ml. 제 1 내지 3항중의 어느 한 항에 있어서, 유기 설파이드가 각 알킬 그룹의 탄소수가 제 1 내지 3인 디알킬 설파이드인 방법.The process according to any one of claims 1 to 3, wherein the organic sulfide is a dialkyl sulfide having from 1 to 3 carbon atoms in each alkyl group. 제 4 항에 있어서, 유기 설파이드가 디메틸 설파이드인 방법.The method of claim 4, wherein the organic sulfide is dimethyl sulfide. 제 1 내지 5항중의 어느 한 항에 있어서, 유기 설파이드가 약 0.1M 내지 약 1M의 농도로 반응 혼합물중에 존재하는 방법.The method of claim 1, wherein the organic sulfide is present in the reaction mixture at a concentration of about 0.1 M to about 1 M. 7. 제 6 항에 있어서, 유기 설파이드가 약 0.5M 내지 약 1M의 농도로 반응 혼합물중에 존재하는 방법.The method of claim 6, wherein the organic sulfide is present in the reaction mixture at a concentration of about 0.5M to about 1M. 제 1 내지 7항중의 어느 한 항에 있어서, 할로산이 염산인 방법.The process according to any one of claims 1 to 7, wherein haloic acid is hydrochloric acid. 제 1 내지 8항중의 어느 한 항에 있어서, 할로산이 약 0.1M 내지 약 1M의 농도로 반응 혼합물중에 존재하는 방법.The method of claim 1, wherein the halo acid is present in the reaction mixture at a concentration of about 0.1 M to about 1 M. 10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880010521A 1987-08-24 1988-08-19 Reduction Method of Methionine Sulfoxide Residue KR890003798A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/088,739 US4835254A (en) 1987-08-24 1987-08-24 Process for reducing methionine sulfoxide residues in peptides or proteins
US07/088,739 1987-08-24

Publications (1)

Publication Number Publication Date
KR890003798A true KR890003798A (en) 1989-04-18

Family

ID=22213162

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880010521A KR890003798A (en) 1987-08-24 1988-08-19 Reduction Method of Methionine Sulfoxide Residue

Country Status (16)

Country Link
US (1) US4835254A (en)
JP (1) JPH02262590A (en)
KR (1) KR890003798A (en)
CN (1) CN1029976C (en)
BE (1) BE1004198A3 (en)
CA (1) CA1315482C (en)
CH (1) CH675879A5 (en)
DE (1) DE3828287A1 (en)
DK (1) DK465588A (en)
FR (1) FR2619820B1 (en)
GB (1) GB2209033B (en)
HU (1) HU200438B (en)
IL (1) IL87479A (en)
IT (1) IT1226864B (en)
NL (1) NL8802041A (en)
SE (1) SE503255C2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220064486A (en) 2020-11-11 2022-05-19 고려대학교 산학협력단 Fluorescent protein sensor capable of quantitatively measuring the degree of free methionine-R-sulfoxide and use thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2682061B2 (en) * 1988-10-07 1997-11-26 藤沢薬品工業株式会社 Method for forming intramolecular disulfide bond of peptide
US5272135A (en) * 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
GB2451441B (en) 2007-07-30 2012-07-11 Lein Applied Diagnostics Ltd Optical alignment apparatus and method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745178A (en) * 1987-04-22 1988-05-17 Eli Lilly And Company Process for selective peptide bond cleavage using sulfoxides and CF3 CO

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220064486A (en) 2020-11-11 2022-05-19 고려대학교 산학협력단 Fluorescent protein sensor capable of quantitatively measuring the degree of free methionine-R-sulfoxide and use thereof
KR20240040062A (en) 2020-11-11 2024-03-27 주식회사 제론메드 Fluorescent protein sensor capable of quantitatively measuring the degree of free methionine-R-sulfoxide and use thereof

Also Published As

Publication number Publication date
IT8821716A0 (en) 1988-08-18
CN1031538A (en) 1989-03-08
SE503255C2 (en) 1996-04-29
GB8819861D0 (en) 1988-09-21
US4835254A (en) 1989-05-30
NL8802041A (en) 1989-03-16
FR2619820B1 (en) 1992-11-13
IT1226864B (en) 1991-02-20
HU200438B (en) 1990-06-28
IL87479A0 (en) 1989-01-31
CH675879A5 (en) 1990-11-15
FR2619820A1 (en) 1989-03-03
CA1315482C (en) 1993-03-30
DE3828287A1 (en) 1989-03-09
SE8802941L (en) 1989-02-25
SE8802941D0 (en) 1988-08-19
GB2209033B (en) 1991-01-02
HUT48560A (en) 1989-06-28
IL87479A (en) 1993-02-21
BE1004198A3 (en) 1992-10-13
JPH02262590A (en) 1990-10-25
DK465588A (en) 1989-03-17
CN1029976C (en) 1995-10-11
DK465588D0 (en) 1988-08-19
GB2209033A (en) 1989-04-26

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