KR890003744A - Method for preparing azole derivatives - Google Patents

Method for preparing azole derivatives Download PDF

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Publication number
KR890003744A
KR890003744A KR870009061A KR870009061A KR890003744A KR 890003744 A KR890003744 A KR 890003744A KR 870009061 A KR870009061 A KR 870009061A KR 870009061 A KR870009061 A KR 870009061A KR 890003744 A KR890003744 A KR 890003744A
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South Korea
Prior art keywords
general formula
organic solvent
inert organic
group
formula
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KR870009061A
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Korean (ko)
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KR890003812B1 (en
Inventor
이덕근
이재목
윤록림
김진웅
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손영희
제일제당 주식회사
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Priority to KR1019870009061A priority Critical patent/KR890003812B1/en
Publication of KR890003744A publication Critical patent/KR890003744A/en
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Publication of KR890003812B1 publication Critical patent/KR890003812B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

아졸 유도체의 제조방법Method for preparing azole derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

다음 일반식(Ⅱ)의 반응성 에스테르를 일반식(Ⅳ)의 4급 포스포늄염을 촉매로하여 일반식(Ⅴ)의 금속 염기 존재하에 일반식(Ⅲ)의 화합물과 불활성 유기용매내의 가온상태에서 반응시켜 일반식(Ⅰ)의 아졸 유도체를 제조하는 방법.The reactive ester of the general formula (II) is catalyzed by the quaternary phosphonium salt of the general formula (IV) in the presence of a metal base of the general formula (V) in a warm state in the compound of the general formula (III) and an inert organic solvent. Reacting to prepare an azole derivative of formula (I). 상기식에서 Ar은 할로 또는 메톡시로 구성된 군으로부터 독립적으로 선택된 1개 또는 2개으 라디칼로 임의 치환된 페닐기 등이며 A는 CH2또는 N, B는 수소 또는 C1-C4의 저급 알카노일이며 X는 메탄설포닐옥시, 벤젠설포닐옥시, 4-메틸벤젠설포닐옥시 등의 설폰산에스테르기이며 Y는 할라이드 또는 보래이트 등이고 R1,R2,R3,R4는 알킬, 벤질, 아릴중에서 적당히 선택된 것이며 M은 소디움 또는 칼륨과 같은 알칼리 금속이다.Wherein Ar is a phenyl group optionally substituted with one or two radicals independently selected from the group consisting of halo or methoxy, A is CH 2 or N, B is hydrogen or lower alkanoyl of C 1 -C 4 and X Is a sulfonic acid ester group such as methanesulfonyloxy, benzenesulfonyloxy, 4-methylbenzenesulfonyloxy, Y is halide or borate, and R1, R2, R3, R4 is appropriately selected from alkyl, benzyl and aryl. M is an alkali metal such as sodium or potassium. 제1항에 있어서, O-알킬화 반응은 40°C 내지 80°C 사이의 온도에서 5시간에서 10시간 사이에 행함을 특징으로 하는 방법.The process according to claim 1, wherein the O-alkylation reaction is carried out at a temperature between 40 ° C. and 80 ° C. for 5 to 10 hours. 제1항에 있어서 불활성 유기용매는 디메틸설폭사이드를 사용하는 것을 특징으로 하는 방법.The method according to claim 1, wherein the inert organic solvent uses dimethyl sulfoxide. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870009061A 1987-08-19 1987-08-19 Process for preparing azol derivatives KR890003812B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870009061A KR890003812B1 (en) 1987-08-19 1987-08-19 Process for preparing azol derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870009061A KR890003812B1 (en) 1987-08-19 1987-08-19 Process for preparing azol derivatives

Publications (2)

Publication Number Publication Date
KR890003744A true KR890003744A (en) 1989-04-17
KR890003812B1 KR890003812B1 (en) 1989-10-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870009061A KR890003812B1 (en) 1987-08-19 1987-08-19 Process for preparing azol derivatives

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Publication number Publication date
KR890003812B1 (en) 1989-10-05

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