KR890002180A - Cephalosporin derivatives - Google Patents

Abstract

No content

Description

Cephalosporin derivatives

Since this is an open matter, no full text was included.

Claims (13)

Cephalosporin derivatives of general formula (I) or salts thereof. In the above general formula, R ¹ is amino which can be protected, R ² is a substituted or unsubstituted heterocyclic group having 1 to 3 hetero atoms selected from the group consisting of nitrogen and sulfur, and R ³ can be protected carboxyl or -COO ^- is. The compound or a salt thereof according to claim 1, wherein R ² is a group of the following general formula. In the above groups, R ⁴ is lower alkenyl, substituted or unsubstituted 5 or 6 membered nitrogen-containing heterocycle, acylamino or substituted or unsubstituted lower alkyl, and R ⁵ and R ⁶ are the same or different and each Hydrogen, lower alkyl, amino, acylamino, carboxyl, carbamoyl, thio carbamoyl or lower alkoxy carbonyl, R ⁷ , R ⁸ and R ⁹ are each lower alkyl, V and W are the same or different and , -CH = or -N = a, Q ₁ and Q ₂ is can form the ventilation of 5 to 6 with the two adjacent carbon atoms, may be included during the ring nitrogen atom, R ³ is -COO ^- to be. The compound according to claim ² or a salt thereof, wherein R ² is a group of formula (a). In the formula above, R ⁴ is lower alkenyl, pyridyl, oxopyrrolidinyl, acylamino or substituted or unsubstituted lower alkyl, wherein the substituents are cyano, hydroxyl, lower alcohol, N- (lower alkyl) Barmoyloxy, carboxyl, amino, N, N-di (lower alkyl) amino, acylamino, (N- (lower alkyl) carbamoyl) amino, (N- (lower alkyl) thiocarbamoyl) amino, Lower alkoxy carbonylamino, lower alkylthio, phenyl, carbamoylphenyl, 2- (lower alkyl) -1,3,4-thiadiazol-5-yl and formula In which R ^a and R ^b are the same or different and are hydrogen, lower alkyl, hydroxyl, amino or lower alkenyl, or R ^a and R ^b together with adjacent nitrogen atoms And Z is oxygen or sulfur and R ⁵ , R ⁶ , V and W are as defined in claim 2. The compound according to claim 3, or a salt thereof, wherein R ² is a group of the general formula: In the above general formula, R ⁴ , R ⁵ and R ⁶ are as defined in claim 3, and V and W are -CH =. The compound or a salt thereof according to claim 4, wherein R ⁵ and R ⁶ are hydrogen. The compound according to claim 4 or a salt thereof, wherein R ² is a group of formula (a '). In the above formula, R ⁴ is lower alkenyl, pyridyl, lower alkyl, N- (lower alkyl) carbamoyl-substituted lower alkyl or phenylsubstituted lower alkyl, and R ⁵ and R ⁶ are As defined. The compound or a salt thereof according to claim 6, wherein R ⁵ and R ⁶ are hydrogen. The compound or a salt thereof according to claim 6, wherein R ⁴ is lower alkenyl or lower alkyl, and R ⁵ and R ⁶ are hydrogen. The compound of any one of claims 2-8, wherein R ¹ is amino. The compound of claim 1, wherein the compound is 7β-{(Z) -2- (2-aminothiazol-4-yl) -2-[((3S) -2-oxopyrrolidin-3-yl) oxyimino ] Acet amido} -3- (1-methyl-40-pyridinio) thiomethyl-3-cepem-4-carboxylate. The compound of claim 1, wherein the compound 7β-{(Z) -2- (2-aminothiazol-4-yl) -2-[((3S) -2-oxopyrrolidin-3-yl) oxyimino] Acet amido} -3- (1-methyl-2-pyridinio) thiomethyl-3-cepem-4-carboxylate. The compound of claim 1, wherein the compound is 7-{(Z) -2- (2-aminothiazol-4-yl) -2-[((3S) -2-oxopyrrolidin-3-yl) oxyimino ] Acet amido} -3- (1-allyl-2-pyridinio) thiomethyl-3-cepem-4-carboxylate. The compound or salt thereof according to claim 1, wherein R ² is a group of the formula In the group of the general formula above, R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , V, W, Q ₁ and Q ₂ are as defined in claim 2 and R ³ is a carboxyl group which can be protected. ※ Note: The disclosure is based on the initial application.