DK0565377T3 - Therapeutic agents for the treatment of Parkinson's disease - Google Patents
Therapeutic agents for the treatment of Parkinson's diseaseInfo
- Publication number
- DK0565377T3 DK0565377T3 DK93302780.7T DK93302780T DK0565377T3 DK 0565377 T3 DK0565377 T3 DK 0565377T3 DK 93302780 T DK93302780 T DK 93302780T DK 0565377 T3 DK0565377 T3 DK 0565377T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- parkinson
- disease
- treatment
- therapeutic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Abstract
Disclosed are therapeutic agents for use in the treatment of Parkinson's disease, such agents being xanthine derivatives of the Formula (I) and their pharmaceutical acceptable salts: <CHEM> where R<1>, R<2> and R<3> are each H, C1-C6 alkyl or allyl; and R<4> is cycloalkyl of 3 to 8 carbon atoms, a - (CH2)n-R<5> group where n is an cycloalkyl of 3 to 8 carbon atoms, a - (CH2)n-R<5> group where n is an integer of from 0-4 and R<5> is an aryl group of 6 to 10 carbon atoms or a heterocyclic group, such aryl or heterocyclic group optionally being substituted by up to 3 substituent(s) selected from C1-C6 alkyl, hydroxy, C1-C6 alkoxy, halogen, nitro and amino; or a <CHEM> group, where Y<1> and Y<2> are each H or CH3 and Z is a substituted or unsubstituted aryl or heterocyclic group as defined under R<5>.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8711592 | 1992-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0565377T3 true DK0565377T3 (en) | 1998-03-16 |
Family
ID=13905960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93302780.7T DK0565377T3 (en) | 1992-04-08 | 1993-04-08 | Therapeutic agents for the treatment of Parkinson's disease |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0565377B1 (en) |
JP (1) | JP2613352B2 (en) |
AT (1) | ATE161723T1 (en) |
BR (1) | BR1100636A (en) |
CA (1) | CA2093403C (en) |
DE (1) | DE69316067T2 (en) |
DK (1) | DK0565377T3 (en) |
ES (1) | ES2112386T3 (en) |
GR (1) | GR3026233T3 (en) |
HK (1) | HK1001835A1 (en) |
NO (1) | NO303265B1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993016604A1 (en) * | 1992-02-19 | 1993-09-02 | Yukio Ishida | Highly water absorbing rice, method of manufacturing same and utilization thereof |
ATE216584T1 (en) * | 1992-07-08 | 2002-05-15 | Kyowa Hakko Kogyo Kk | XANTHINE DERIVATIVES AS ANTIDEPRESSANTS |
JP2613355B2 (en) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | Parkinson's disease treatment |
WO1994025462A1 (en) * | 1993-05-03 | 1994-11-10 | The United States Of America, Represented By The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
CA2160928C (en) * | 1993-07-28 | 2005-07-05 | Garry Fenton | Compounds as pde iv and tnf inhibitors |
DE69526822T2 (en) * | 1994-02-23 | 2003-01-23 | Kyowa Hakko Kogyo Kk | Xanthine derivatives |
AU3784597A (en) * | 1996-08-07 | 1998-02-25 | Kyowa Hakko Kogyo Co. Ltd. | Fat emulsion containing xanthine derivative |
EP1666041A3 (en) | 1997-09-05 | 2008-04-02 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives for treating neurodegenerative disorders |
CA2464031A1 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
AR044069A1 (en) | 2003-04-25 | 2005-08-24 | Nova Cardia Inc | A METHOD OF IMPROVED DIURESIS IN INDIVIDUALS WITH DETERIORATED RENAL FUNCTION |
WO2005028434A2 (en) | 2003-09-18 | 2005-03-31 | Conforma Therapeutics Corporation | Novel heterocyclic compounds as hsp90-inhibitors |
WO2005072739A1 (en) | 2004-01-28 | 2005-08-11 | Kyowa Hakko Kogyo Co., Ltd. | Drug for treating migraine |
KR20080004550A (en) * | 2005-03-30 | 2008-01-09 | 콘포마 세러퓨틱스 코포레이션 | Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors |
JP2008536919A (en) * | 2005-04-22 | 2008-09-11 | ノヴァカーディア,インク. | Production of emulsions of pharmaceutical compositions |
JP2010513353A (en) * | 2006-12-22 | 2010-04-30 | シュバルツ ファルマ アクチェンゲゼルシャフト | 8-Ethynylxanthine derivatives as selective A2A receptor antagonists |
US7994357B2 (en) * | 2009-04-03 | 2011-08-09 | Naturewise Biotech & Medicals Corporation | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase |
WO2020125779A1 (en) * | 2018-12-21 | 2020-06-25 | Sunshine Lake Pharma Co., Ltd. | 8-substituted styryl xanthine derivatives and uses thereof |
CN111333648B (en) * | 2019-04-24 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 8-substituted aromatic ring vinyl xanthine derivative and application thereof |
CN110041331B (en) * | 2019-05-17 | 2020-08-07 | 广东东阳光药业有限公司 | Styrylxanthine derivative and use thereof |
CN112409360B (en) * | 2019-08-22 | 2022-12-23 | 广东东阳光药业有限公司 | Heteroaryl vinyl xanthine derivatives and uses thereof |
WO2021093701A1 (en) * | 2019-11-11 | 2021-05-20 | Sunshine Lake Pharma Co., Ltd. | 8-substituted styryl xanthine derivatives and uses thereof |
CN111018856B (en) * | 2019-12-12 | 2021-10-01 | 广东东阳光药业有限公司 | 8-substituted styrylxanthine derivatives and uses thereof |
CN111072663B (en) * | 2019-12-12 | 2021-10-01 | 广东东阳光药业有限公司 | 8-substituted styrylxanthine derivatives and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2059577B1 (en) * | 1969-07-30 | 1973-08-10 | Parke Davis & Co | |
DE3843117A1 (en) * | 1988-12-22 | 1990-06-28 | Boehringer Ingelheim Kg | NEW XANTHINE DERIVATIVES WITH ADENOSINE ANTAGONISTIC EFFECT |
GB8906792D0 (en) * | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
DE4019892A1 (en) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | New xanthine derivs. are selective A1 adenosine antagonists - useful for treating CNS disorders (e.g. senile dementia) and heart and circulation disorders |
FR2665636B1 (en) * | 1990-08-10 | 1994-10-07 | Adir | USE OF A TRIMETHYL-1,3,7 XANTHINE DERIVATIVE FOR THE TREATMENT OF MEMORY DISORDERS, INTELLECTUAL DISORDERS OF SENESCENCE AND ALZHEIMER'S DISEASE. |
CA2094270C (en) * | 1990-10-18 | 1997-01-21 | Fumio Suzuki | Xanthine derivatives |
-
1993
- 1993-04-05 CA CA002093403A patent/CA2093403C/en not_active Expired - Lifetime
- 1993-04-06 NO NO931317A patent/NO303265B1/en not_active IP Right Cessation
- 1993-04-08 JP JP5081953A patent/JP2613352B2/en not_active Expired - Fee Related
- 1993-04-08 ES ES93302780T patent/ES2112386T3/en not_active Expired - Lifetime
- 1993-04-08 AT AT93302780T patent/ATE161723T1/en not_active IP Right Cessation
- 1993-04-08 DE DE69316067T patent/DE69316067T2/en not_active Expired - Lifetime
- 1993-04-08 DK DK93302780.7T patent/DK0565377T3/en active
- 1993-04-08 EP EP93302780A patent/EP0565377B1/en not_active Expired - Lifetime
-
1997
- 1997-05-13 BR BR1100636-6A patent/BR1100636A/en active IP Right Grant
-
1998
- 1998-02-04 HK HK98100812A patent/HK1001835A1/en not_active IP Right Cessation
- 1998-02-25 GR GR980400413T patent/GR3026233T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE161723T1 (en) | 1998-01-15 |
ES2112386T3 (en) | 1998-04-01 |
JPH0616559A (en) | 1994-01-25 |
EP0565377A1 (en) | 1993-10-13 |
HK1001835A1 (en) | 1998-07-10 |
NO931317L (en) | 1993-10-11 |
JP2613352B2 (en) | 1997-05-28 |
CA2093403C (en) | 1999-08-10 |
EP0565377B1 (en) | 1998-01-07 |
DE69316067T2 (en) | 1998-07-02 |
CA2093403A1 (en) | 1993-10-09 |
NO303265B1 (en) | 1998-06-22 |
DE69316067D1 (en) | 1998-02-12 |
NO931317D0 (en) | 1993-04-06 |
BR1100636A (en) | 2000-04-18 |
GR3026233T3 (en) | 1998-05-29 |
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