KR890002125A - Method for preparing 4-amino-6, 7-dimethoxy quinazoline derivatives. - Google Patents

Method for preparing 4-amino-6, 7-dimethoxy quinazoline derivatives. Download PDF

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Publication number
KR890002125A
KR890002125A KR1019870007670A KR870007670A KR890002125A KR 890002125 A KR890002125 A KR 890002125A KR 1019870007670 A KR1019870007670 A KR 1019870007670A KR 870007670 A KR870007670 A KR 870007670A KR 890002125 A KR890002125 A KR 890002125A
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South Korea
Prior art keywords
alkyl
solvent
carbon atoms
compound
formula
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KR1019870007670A
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Korean (ko)
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KR890004558B1 (en
Inventor
이윤우
김동신
조양래
장대식
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문광석
대한약품공업 주식회사
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Priority to KR1019870007670A priority Critical patent/KR890004558B1/en
Priority to ES8802218A priority patent/ES2007263A6/en
Publication of KR890002125A publication Critical patent/KR890002125A/en
Application granted granted Critical
Publication of KR890004558B1 publication Critical patent/KR890004558B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음No content

Description

4-아미노-6,7-디메톡시 퀴나졸린 유도체의 제조방법.Method for preparing 4-amino-6,7-dimethoxy quinazoline derivatives.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

다음 구조식(XII)의 화합물을 구조식(XIII)의 화합물과 비양자성 극성 용매 존재하 가온상태에서 고리화 반응시킴을 특징으로 하는 구조식(I)의 화합물 및 그의 산부가염을 제조하는 방법.A process for preparing a compound of formula (I) and an acid addition salt thereof, wherein the compound of formula (XII) is cyclized with a compound of formula (XIII) in a warm state in the presence of an aprotic polar solvent. 상기식에서, R은 푸릴, 테트라하이드로푸릴, 1,4-벤조디옥사-2-일, 혹은 5개이하의 탄소원자를 갖는 알킬기를 표시하며, n은 2 혹은 3의 정수이다. R', R", R"'는 서로 동일하거나 다른 알킬, 아릴기, 알킬기와 아릴기를 동시에 갖는 삼급아민이거나, R', R" R"'중 둘 혹은 셋이 고리를 이루는 질소고리 삼급아민 또는 R', R", R"'가 하나의 방향족 구조를 이루는 방향족 질소고리 삼급아민을 표시한다. HX는 염화수소, 브롬화수소, 요오드화수소, 알킬 혹은 아릴술폰산을 표시한다.Wherein R represents furyl, tetrahydrofuryl, 1,4-benzodioxa-2-yl, or an alkyl group having 5 or less carbon atoms, and n is an integer of 2 or 3. R ', R ", R"' is a tertiary amine having the same or different alkyl, aryl, alkyl and aryl groups at the same time, or a nitrogen ring tertiary amine in which two or three of R ', R "R"' form a ring, or R ', R ", R"' represents an aromatic nitrogen ring tertiary amine forming one aromatic structure. HX represents hydrogen chloride, hydrogen bromide, hydrogen iodide, alkyl or arylsulfonic acid. 제1항에 있어서, 비양성자성 극성용매로서 탄소수 1-4의 저급알킬, 포름아미드, 디메틸포름아미드, 디메틸아세트아미드, 디메틸술폭시드 중에서 선택하거나 이들 사이의 혼합용매 혹은 이들 이외의 다른 유기 용매와의 혼합용매를 사용함을 특징으로 하는 제조방법.The method according to claim 1, wherein the aprotic polar solvent is selected from lower alkyl having 1 to 4 carbon atoms, formamide, dimethylformamide, dimethylacetamide, dimethyl sulfoxide or a mixed solvent therebetween or other organic solvents therebetween. Method for producing a mixed solvent of the. 제2항에 있어서, 탄소수 1-4의 저급알콜 용매로서 메틸알콜 또는 에틸알콜을 사용함을 특징으로 하는 제조방법.The method according to claim 2, wherein methyl alcohol or ethyl alcohol is used as the lower alcohol solvent having 1 to 4 carbon atoms. 제2항에 있어서, 다른 유기용매로서 염화메틸렌, 클로로포름, 아세톤, 염화에틸렌, 에틸아세테이트, 에테르를 사용함을 특징으로 하는 제조방법.The method according to claim 2, wherein methylene chloride, chloroform, acetone, ethylene chloride, ethyl acetate, and ether are used as another organic solvent. 제1항에 있어서, 반응온도는 60-150℃에서 행함을 특징으로 하는 제조방법.The process according to claim 1, wherein the reaction temperature is carried out at 60-150 ° C. ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is to be disclosed based on the initial application.
KR1019870007670A 1987-07-15 1987-07-15 Process for preparing 4-amino-6,7-dimethoxy quinazoline derivatives KR890004558B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019870007670A KR890004558B1 (en) 1987-07-15 1987-07-15 Process for preparing 4-amino-6,7-dimethoxy quinazoline derivatives
ES8802218A ES2007263A6 (en) 1987-07-15 1988-07-14 4-Amino 6,7-di:methoxy quinazoline deriv. prepn. - by cyclising reaction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019870007670A KR890004558B1 (en) 1987-07-15 1987-07-15 Process for preparing 4-amino-6,7-dimethoxy quinazoline derivatives

Publications (2)

Publication Number Publication Date
KR890002125A true KR890002125A (en) 1989-04-08
KR890004558B1 KR890004558B1 (en) 1989-11-15

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KR1019870007670A KR890004558B1 (en) 1987-07-15 1987-07-15 Process for preparing 4-amino-6,7-dimethoxy quinazoline derivatives

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KR (1) KR890004558B1 (en)
ES (1) ES2007263A6 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100446864B1 (en) * 2002-02-06 2004-09-04 에이티엔써플라이 주식회사 St0rage glow license number plate and manufacturing process thereof
KR102372588B1 (en) * 2021-09-09 2022-03-10 김학도 Vehicle license plate laminate film attachment device

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000092375A (en) * 1998-07-17 2000-03-31 Sony Corp Signal processing unit and its control method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100446864B1 (en) * 2002-02-06 2004-09-04 에이티엔써플라이 주식회사 St0rage glow license number plate and manufacturing process thereof
KR102372588B1 (en) * 2021-09-09 2022-03-10 김학도 Vehicle license plate laminate film attachment device

Also Published As

Publication number Publication date
ES2007263A6 (en) 1989-06-01
KR890004558B1 (en) 1989-11-15

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