KR880009652A - 3-5-디클로로메토트랙세이트를 사용하는 류마티스성 관절염 치료법 및 그에 유용한 조성물 - Google Patents
3-5-디클로로메토트랙세이트를 사용하는 류마티스성 관절염 치료법 및 그에 유용한 조성물 Download PDFInfo
- Publication number
- KR880009652A KR880009652A KR1019880001729A KR880001729A KR880009652A KR 880009652 A KR880009652 A KR 880009652A KR 1019880001729 A KR1019880001729 A KR 1019880001729A KR 880001729 A KR880001729 A KR 880001729A KR 880009652 A KR880009652 A KR 880009652A
- Authority
- KR
- South Korea
- Prior art keywords
- dichloro
- diamino
- methylamino
- benzoyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H59/00—Control inputs to control units of change-speed-, or reversing-gearings for conveying rotary motion
- F16H59/36—Inputs being a function of speed
- F16H59/38—Inputs being a function of speed of gearing elements
- F16H59/40—Output shaft speed
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16H—GEARING
- F16H59/00—Control inputs to control units of change-speed-, or reversing-gearings for conveying rotary motion
- F16H59/48—Inputs being a function of acceleration
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 관절염 및 진행성 관절 열화의 치료에 있어 사용되는, 향상된 치료 계수를 가지며, 약제학적으로 허용가능한 담체와의 혼합물안에 유효량의 N-{3,5-디클로로-4-[(2,4-디아미노-6-프레리딜메틸)메틸아미노]벤조일}글루탐 산 또는 약제학적으로 허용가능한 그의 염을 갖는 것을 특징으로 하는 프테리딘 제약 조성물.
- 제1항에 있어서, 활성 성분이N-{3,5-디클로로-4-[(2,4-디아미노-6-프테리딜메틸)메틸아미노]벤조일}글루탐 산이고 조성물이 단위 복용 경구적 정제 형태로 있는 치료용 조성물.
- 유효량의N-{3,5-디클로로-4-[(2,4-디아미노-6-프테리딜메틸)메틸아미노]벤조일}글루탐 산 또는 그의 약제학적으로 허용 가능한 염을 투여하는 것을 특징으로 하는, 관절염 및 진행성 관절 열화의 치료방법.
- 제3항에 있어서, 치료 계수가 칼슘 로이코보린의 후 투여에 의해 본질적으로 증가되는 방법.
- 제4항에 있어서, 보조약 관절염을 3,5-디클로로메토트렉세이트로 치료하고, 치료 계수가 약 6인 방법.
- 제3항에 있어서, 활성 성분이 3,5-디클로로메토트렉세이트이고 바람직한 복용 요법이 하루당 1-3mg/체중 kg 인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/017,286 | 1987-02-20 | ||
US07/017,286 US4746662A (en) | 1987-02-20 | 1987-02-20 | Treatment of arthritis with 3,5-dichloromethotrexate |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880009652A true KR880009652A (ko) | 1988-10-04 |
Family
ID=21781766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880001729A KR880009652A (ko) | 1987-02-20 | 1988-02-19 | 3-5-디클로로메토트랙세이트를 사용하는 류마티스성 관절염 치료법 및 그에 유용한 조성물 |
Country Status (5)
Country | Link |
---|---|
US (1) | US4746662A (ko) |
EP (1) | EP0282690A3 (ko) |
JP (1) | JPS63208521A (ko) |
KR (1) | KR880009652A (ko) |
AU (1) | AU1197388A (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2090075T3 (es) * | 1989-12-11 | 1996-10-16 | American Cyanamid Co | Procedimiento para la preparacion de diastereoisomeros opticamente puros de compuestos de tetrahidrofolato. |
US5030634A (en) * | 1990-03-29 | 1991-07-09 | Krumdieck Carlos L | 10-deazaaminopterin: a new arthritis remittive drug |
US20100061984A1 (en) * | 2006-01-20 | 2010-03-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for modulation of suppressor t cell activation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4426384A (en) * | 1982-08-05 | 1984-01-17 | John R. A. Simoons | Treatment of rheumatoid arthritis and related diseases |
-
1987
- 1987-02-20 US US07/017,286 patent/US4746662A/en not_active Expired - Lifetime
-
1988
- 1988-01-18 EP EP88100587A patent/EP0282690A3/en not_active Withdrawn
- 1988-02-16 JP JP63031986A patent/JPS63208521A/ja active Pending
- 1988-02-19 KR KR1019880001729A patent/KR880009652A/ko not_active Application Discontinuation
- 1988-02-19 AU AU11973/88A patent/AU1197388A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0282690A2 (en) | 1988-09-21 |
EP0282690A3 (en) | 1990-01-10 |
AU1197388A (en) | 1988-08-25 |
JPS63208521A (ja) | 1988-08-30 |
US4746662A (en) | 1988-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITB | Written withdrawal of application |