KR880009000A - Method for preparing 5-aryl-2,4-diaalkyl-3H-1,2,4-triazole-3-thione - Google Patents

Method for preparing 5-aryl-2,4-diaalkyl-3H-1,2,4-triazole-3-thione Download PDF

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Publication number
KR880009000A
KR880009000A KR1019880000617A KR880000617A KR880009000A KR 880009000 A KR880009000 A KR 880009000A KR 1019880000617 A KR1019880000617 A KR 1019880000617A KR 880000617 A KR880000617 A KR 880000617A KR 880009000 A KR880009000 A KR 880009000A
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South Korea
Prior art keywords
thione
triazole
diaalkyl
aryl
preparing
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KR1019880000617A
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Korean (ko)
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KR960004864B1 (en
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피.밀러 프란시스
엠.케인 존
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게리 디.스트리트
메렐다우 파마슈티칼스 인코포레이티드
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Publication of KR880009000A publication Critical patent/KR880009000A/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.No content.

Description

5-아릴-2,4-디아킬-3H-1,2,4-트리아졸-3-티온의 제조방법Method for preparing 5-aryl-2,4-diaalkyl-3H-1,2,4-triazole-3-thione

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (9)

2-R2-4-R4-5-Rn-페닐-2,4-디하이드로-3H-1,2,4-트리아졸-3-온을 브론 트리클로라이드의 존재하에서 비스-(트리사이클로헥실틴)설파이드와 반응시킴에 의해 상응하는 2,4-디하이드로-3H-1,2,4-트리아졸-3-온을 티온화 시킴을 특징으로 하여 일반식 (I)의 화합물 및 이의 토오토머를 제조하는 방법.2-R 2 -4-R 4 -5-R n -phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one was converted to bis- (tricyclo Compounds of formula (I) and their earths, characterized by thionizing the corresponding 2,4-dihydro-3H-1,2,4-triazol-3-one by reaction with hexyltin) sulfide How to make an automer. 상기식에서, R은 할로게노, C1-6저급알킬, C1-6저급알콕시, 하이드록시, 트리플루오로메틸, 또는 메틸렌디옥시이고, n은 0,1 또는 2이며, R2및 R4는 독립적으로 C1-6저급 알킬을 나타낸다.Wherein R is halogeno, C 1-6 lower alkyl, C 1-6 lower alkoxy, hydroxy, trifluoromethyl, or methylenedioxy, n is 0, 1 or 2, R 2 and R 4 Independently represents C 1-6 lower alkyl. 제1항의 반응혼합물을 플루오르화칼륨으로 처리함을 특징으로 하여 제1항의 반응 생성물의 유리를 촉진 시키는 방법.A process for promoting the release of the reaction product of claim 1, characterized by treating the reaction mixture of claim 1 with potassium fluoride. 제1항에 있어서, R이 클로로인 방법.The method of claim 1, wherein R is chloro. 제1항에 있어서, R2및 R4가 각각 메틸인 방법.The method of claim 1, wherein R 2 and R 4 are each methyl. 제4항에 있어서, R이 클로로인 방법.The method of claim 4, wherein R is chloro. 제4항에 있어서, R이 플루오로인 방법.The method of claim 4, wherein R is fluoro. 제1항에 있어서, n이 1인 방법.The method of claim 1 wherein n is one. 제5항에 있어서, n이 1인 방법.6. The method of claim 5 wherein n is one. 제1항에 있어서, 5-(4-클로로페닐)-2,4-디메틸-3H-1,2,4-트리아졸-3-티온을 제조하는 방법.The process of claim 1, wherein 5- (4-chlorophenyl) -2,4-dimethyl-3H-1,2,4-triazole-3-thione is prepared. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880000617A 1987-01-27 1988-01-27 Process for the preparation of 5-aryl-2,4-dialkyl-3h-1,24-triazole-3-thiones KR960004864B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US730687A 1987-01-27 1987-01-27
US007.306 1987-01-27
US07/007306 1987-01-27

Publications (2)

Publication Number Publication Date
KR880009000A true KR880009000A (en) 1988-09-13
KR960004864B1 KR960004864B1 (en) 1996-04-16

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Application Number Title Priority Date Filing Date
KR1019880000617A KR960004864B1 (en) 1987-01-27 1988-01-27 Process for the preparation of 5-aryl-2,4-dialkyl-3h-1,24-triazole-3-thiones

Country Status (4)

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JP (1) JPS63201175A (en)
KR (1) KR960004864B1 (en)
DK (1) DK35688A (en)
IE (1) IE880195L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816882A1 (en) * 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Use of known and new triazolone derivatives as medicaments, especially for treatment of neurodegenerative disorders and cerebral ischemia

Also Published As

Publication number Publication date
DK35688D0 (en) 1988-01-26
IE880195L (en) 1988-07-27
KR960004864B1 (en) 1996-04-16
DK35688A (en) 1988-07-28
JPS63201175A (en) 1988-08-19

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