KR880008804A - 교미성이 개선된 경구 투여용 제제 - Google Patents
교미성이 개선된 경구 투여용 제제 Download PDFInfo
- Publication number
- KR880008804A KR880008804A KR1019880000753A KR880000753A KR880008804A KR 880008804 A KR880008804 A KR 880008804A KR 1019880000753 A KR1019880000753 A KR 1019880000753A KR 880000753 A KR880000753 A KR 880000753A KR 880008804 A KR880008804 A KR 880008804A
- Authority
- KR
- South Korea
- Prior art keywords
- formulation
- polymer material
- average particle
- particle diameter
- microns
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 TE-031 벌크와 TE-031 본 발명에 의한 제제에 대한 혈중 농도-시간 지표 곡선임.
Claims (8)
- 약제와, 그의 표면에 도포된, 60 마이크론 이하의 평균 입자 직경을 갖고 위액 중에서 용해되는 미립자상 폴리머 물질로 되는 피복층을 함유하는 코아 물질로 되는, 교미성이 개선된 경구 투여용 제제.
- 제1항에 있어서, 상기 위액-용해성 폴리머 물질이 폴리비닐 아세탈 디에틸아미노아세테이트 또는 디메틸아미노에틸 메타크릴레이트/메타크릴산 코폴리머인 제제.
- 제1항에 있어서, 상기 위액-용해성 폴리머 물질이 5 내지 20 마이크론의 평균 입자 직경을 갖는 제제.
- 제1항에 있어서, 상기 위액-용해성 폴리머 물질의 평균 입자 직경의 적어도 10배의 평균 입자 직경을 갖는 제제.
- 제4항에 있어서, 600마이크론 이하의 평균 입자 직경을 갖는 제제.
- 제1항에 의한 제제로부터 제조한 단위 투여형.
- 제6항에 있어서, 과립제, 펠릿제, 캡슐제, 환제, 정제, 당의정 또는 건조 시럽제인 단위 투여형.
- 약제와 필요에 따라서 위액-용해성 폴리머 물질을 함유하는 휘발성 액체의 분시 액체 소적을 60마이크론 이하의 평균 입자 직경을 갖는 위액-용해성 미립자상 폴리머 물질로 되는 분말층 상에 적하시켜서 액체 소적의 표면이 위액-용해성 미립자상 폴리머 물질로 피복되게한 후, 피복 입자를 건조시키는 것으로 되는, 제1항에 의한 경구 투여용 제제의 제조 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-19828 | 1987-01-03 | ||
JP62019828A JPS63188621A (ja) | 1987-01-30 | 1987-01-30 | 矯味経口製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880008804A true KR880008804A (ko) | 1988-09-13 |
Family
ID=12010153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880000753A KR880008804A (ko) | 1987-01-30 | 1988-01-29 | 교미성이 개선된 경구 투여용 제제 |
Country Status (4)
Country | Link |
---|---|
US (1) | US4892740A (ko) |
EP (1) | EP0277042A3 (ko) |
JP (1) | JPS63188621A (ko) |
KR (1) | KR880008804A (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960011236B1 (ko) * | 1987-05-08 | 1996-08-21 | 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 | 제약학적 조성물 및 고체 제형 |
DE69005768T2 (de) * | 1989-04-18 | 1994-04-28 | Taisho Pharmaceutical Co Ltd | Verfahren zur herstellung einer geschmacksmaskiertenzubereitung. |
US5776493A (en) * | 1989-07-14 | 1998-07-07 | Alza Corporation | Oral osmotic device for delivery of nystatin with hydrogel driving member |
US5021053A (en) * | 1989-07-14 | 1991-06-04 | Alza Corporation | Oral osmotic device with hydrogel driving member |
US5082669A (en) * | 1989-07-20 | 1992-01-21 | Dainippon Pharmaceutical Co., Ltd. | Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked |
US5248310A (en) * | 1992-03-27 | 1993-09-28 | Alza Corporation | Oral osmotic device with hydrogel driving member |
US5512299A (en) * | 1992-03-30 | 1996-04-30 | Alza Corporation | Method of treating oral inflammatory disease |
WO1993024109A1 (en) * | 1992-06-04 | 1993-12-09 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
US5573776A (en) * | 1992-12-02 | 1996-11-12 | Alza Corporation | Oral osmotic device with hydrogel driving member |
US5376384A (en) * | 1992-12-23 | 1994-12-27 | Kinaform Technology, Inc. | Delayed, sustained-release pharmaceutical preparation |
WO1999017742A2 (en) * | 1997-10-03 | 1999-04-15 | Elan Corporation, Plc | Taste masked formulations |
DE69808670T2 (de) * | 1997-12-31 | 2003-07-03 | Choongwae Pharma Corp | Herstellungsverfahren und zusammensetzung einer oralen zubereitung von itraconazol |
UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
FR2781793B1 (fr) * | 1998-08-03 | 2001-07-20 | Prographarm Lab | Procede de fabrication de granules de gabapentine enrobes |
SI20150A (sl) * | 1999-02-19 | 2000-08-31 | Lek, Tovarna Farmacevtskih In | Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina |
FR2816507B1 (fr) * | 2000-11-16 | 2003-02-28 | Ethypharm Lab Prod Ethiques | Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules |
CO5400144A1 (es) * | 2002-03-11 | 2004-05-31 | Novartis Ag | Compuestos organicos |
JP4731941B2 (ja) * | 2005-02-14 | 2011-07-27 | 大正薬品工業株式会社 | 経口製剤用粒子 |
US20080081067A1 (en) * | 2006-10-03 | 2008-04-03 | Gupta Manishkumar | Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof |
US11202741B2 (en) * | 2015-09-30 | 2021-12-21 | Amorepacific Corporation | Self-restorable core-shell capsule |
KR20170038677A (ko) * | 2015-09-30 | 2017-04-07 | (주)아모레퍼시픽 | 자가회복 가능한 코어-쉘 캡슐 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL250281A (ko) * | 1960-04-07 | |||
ZA718014B (en) * | 1970-12-23 | 1972-08-30 | Beecham Group Ltd | Pharmaceutical formulations |
DE2406625C3 (de) * | 1973-02-27 | 1979-11-08 | Zenyaku Kogyo K.K., Tokio | Verfahren zum Überziehen von festen Teilchen mit einem im Verdauungstrakt löslichen Film und Vorrichtung zu seiner Durchführung |
JPS52139715A (en) * | 1976-05-14 | 1977-11-21 | Nippon Kayaku Co Ltd | Coated granules of alkali polyacrylate |
FR2420994A1 (fr) * | 1978-03-30 | 1979-10-26 | Pentel Kk | Microcapsules ayant une paroi en substance minerale et procede de leur preparation |
JPS57120518A (en) * | 1981-01-19 | 1982-07-27 | Tanabe Seiyaku Co Ltd | Preparation of microcapsule |
JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
JPS57197214A (en) * | 1981-05-29 | 1982-12-03 | Tanabe Seiyaku Co Ltd | Rapid-releasing microcapsule and its preparation |
DE3135329A1 (de) * | 1981-09-05 | 1983-03-24 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von trockenpulvern oxidationsempfindlicher substanzen |
FR2521450B1 (fr) * | 1982-02-15 | 1987-12-24 | Eurand France | Procede et appareil pour la production de granules parfaitement spheriques et poreux, et granules pour l'industrie pharmaceutique ainsi obtenus |
DE3208791A1 (de) * | 1982-03-11 | 1983-09-22 | Röhm GmbH, 6100 Darmstadt | Verfahren zum ueberziehen von arzneiformen mittes eines in wasser dispergierten ueberzugsmittels |
-
1987
- 1987-01-30 JP JP62019828A patent/JPS63188621A/ja active Pending
-
1988
- 1988-01-25 US US07/147,860 patent/US4892740A/en not_active Expired - Fee Related
- 1988-01-29 EP EP88300802A patent/EP0277042A3/en not_active Withdrawn
- 1988-01-29 KR KR1019880000753A patent/KR880008804A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0277042A2 (en) | 1988-08-03 |
US4892740A (en) | 1990-01-09 |
EP0277042A3 (en) | 1989-08-30 |
JPS63188621A (ja) | 1988-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |