KR880000395A - Pyridineethanolamine derivative - Google Patents

Abstract

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Description

Pyridineethanolamine derivative

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Claims (12)

Pyridineethanolamine derivatives of general formula (I) and their physiologically acceptable salts. Where n is 1 or 2, X is H, lower-alkyl, lower-alkoxy-lower-alkyl or The following general formula (Xa) group, Z is a group represented by the following general formula (Z ¹ ), (Z ² ) or (Z ³ ), R ^O is lower-alkyl, COR ⁴ or C (R ⁵ ) = CHCOR ⁴ , R is equal to OR ⁰ or OR ″, R ″ is H, lower-alkyl, lower-alkanoyl, (CH ₂ ) _1-6 -OH (CH ₂ ) _1-6 -O (CH ₂ ) _1-6 -R ⁶ or (CH ₂ ) _1-6 -COR ⁴ , R ¹ and R ^a are H, lower-alkanoyl, benzoyl or (CH ₂ ) _1-6 -OH, R ² and R ^b are H, CI, Br or CF ₃ , R ³ and R ⁵ are H, or CH ₃ , R ⁴ is hydroxy, lower-alkoxy or N (R ⁷ , R ⁸ ), R ⁶ is H, R ^g , OH or COR ⁴ , R ⁷ and R ⁸ are H, lower-alkyl, R ^c and R ^e are H, CI, F, Br or CF ₃ , R ^d is H or NH ₂ , R ^f is H, CH ₃ CONH, NH ₂ COCH ₂ or R ₉ CH ₂ CH ₂ OCH ₂ CH ₂ O, R ^g and R ⁹ are phenyl or phenyl substituted with CI, F or Br. The compound of claim 1, wherein the residue R ⁴ in group Y is lower-alkoxy or N (R ⁷ , R ⁸ ). The compound of claim 1 or 2, wherein n is 1, R ¹ is hydrogen, R ² is chlorine at the 6-position of the 2-pyridyl residue and Y is phenyl substituted with R at the p-position. 4. A compound according to claim 1,2 or 3 wherein X is hydrogen or group X ^a : R ^a is hydrogen: Z is 6-chloro-2-pyridyl: Y is 2-ethoxyethoxy at the p-position, Phenyl substituted with 2-phenethoxy or methoxycarbonyl methoxy. 4. The compound of claim 1, wherein X is group X ^a : R ^a is hydrogen: Z is phenoxymethyl substituted with carbamoylmethyl, acetamide or 2-phenethoxyethoxy at the p-position. : Y is p- (2-ethoxyethoxy) -phenyl. 6. Compounds according to 1,2,3,4 or 5, wherein R ³ is hydrogen or methyl with R-configuration. The compound according to claim 1 or 2, wherein methyl p-[(R) -2-[[(R) -2-(-6-chloro-2-pyridyl) -2-hydroxyethyl] amino] propyl] benzoate . Methyl P-[(R) -2-[[(R) -2- (6-chloro-2-pyridyl) -2-hydroxyethyl] [(S) -m-chloro β-hydroxyphenethyl] Amino] propyl] benzoate, α, α '-[[[(R) -P- (2-ethoxyethoxy) -α-methylphenethyl] imino] dimethylene] bis [(RS) -6-chloro-2-pyridinmethanol] , (RS) -6-chloro-α-[[[(R) -P- (2-ethoxyethoxy) -α-methylphenethyl] imino] methyl] -2-pyridinemethanol α, α '-[ [[P- (2-ethoxyethoxy) phenethyl] imino] dimethylene] bis [(RS) -6-chloro-2-pyridinmethanol], (R) -6-bromo-α-[[[(RS) -2- (6-bromo-2-pyridyl) -2-hydroxyethyl] [(R) -P- (2-ethoxy Ethoxy) -α-methylphenethyl] amino] methyl] -2-pyrimidineethanol], (R) -6-chloro-α-[[[(S) -2- (6-chloro-2-pyridyl) -2-hydroxyethyl] [(R) -α-menyl-P- (2- Phenethoxyethoxy) phenethyl] amino] methyl] -2-pyridinemethanol], 2- [P-[(RS) -3-[[(RS) -2- (6-chloro-2-pyridyl) -2-hydroxyethyl] [P- (2-ethoxyethoxy) phenethyl ] Amino] -2-hydroxypropoxy] phenyl] acetamide, 4 '-[(RS) -3-] [(RS) -2- (6-chloro-2-pyridyl) -2-hydroxyethyl] [(R) -P- (2-ethoxyethoxy) -α-methyleneethyl] amino] -2-hydroxypropoxy acetanilide and 6-chloro-α-[[[(R) -P- (2-ethoxyethoxy) -α-methylphenethyl] [(RS) -2-hydroxy-3- [P- [2- (pen Ethoxy) ethoxy] phenoxy] propyl] amino] methyl] -2-pyridinmethanol. A general formula (I) compound according to any one of claims 1 to 7 as a medicament for treating obesity, diabetes, and a condition associated with increased protein destruction, or as a feed for animal feed, and its physiologically acceptable salt. A pharmaceutical formulation containing a compound of formula (I) according to any one of claims 1 to 7 or a physiologically acceptable salt thereof. The amines of the general formula (II) below are alkylated with a reagent introducing one of group X ³ or group X, optionally functionally modifying the reactive substituents present in group Y of the reaction product, and optionally, amine nitrogen A general formula according to any one of claims 1 to 7, characterized by esterifying a hydroxy group present at the β-position at an atom and optionally converting the compound of formula (I) into a salt. (I) A method of preparing a compound and its physiologically acceptable salt. (X ¹ , X ² ) NC (H, R ³ ) (CH ₂ ) _n Y (II) In the above formula One of X ¹ and X ² is hydrogen and the other is one of the meanings of X (X ₃ ) Group. Formula (I) compound according to any one of claims 1 to 7, or physiologically, in the preparation of a pharmaceutical preparation or animal feed for animal feed for treating obesity, diabetes and conditions associated with increased protein destruction. Acceptable use of salts. Inventions described herein, in particular according to examples. ※ Note: The disclosure is based on the initial application.