KR870011073A - Tetrahydro naphthalene derivative and preparation method thereof - Google Patents

Tetrahydro naphthalene derivative and preparation method thereof Download PDF

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Publication number
KR870011073A
KR870011073A KR870004688A KR870004688A KR870011073A KR 870011073 A KR870011073 A KR 870011073A KR 870004688 A KR870004688 A KR 870004688A KR 870004688 A KR870004688 A KR 870004688A KR 870011073 A KR870011073 A KR 870011073A
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KR
South Korea
Prior art keywords
compound
formula
tetrahydro
propenyl
tetramethyl
Prior art date
Application number
KR870004688A
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Korean (ko)
Inventor
클라우스 미하엘
로엘리거 페테
Original Assignee
존 에스 삭스
호프만-라 로슈 코포레이티드
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Application filed by 존 에스 삭스, 호프만-라 로슈 코포레이티드 filed Critical 존 에스 삭스
Publication of KR870011073A publication Critical patent/KR870011073A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

테트라하이드로 나프탈렌유도체 및 그의 제조방법Tetrahydro naphthalene derivative and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (11)

일반식(I)의 화합물.Compound of general formula (I). 상기식에서, R1은 o-, m- 또는 p-하이드록시페닐 ; 2,3-,2,4-,2,5-,2,6-,3,4- 또는 3,5-디하이드록시페닐 ; 또는 2,3,4-,2,3,5-,2,4,5-,2,4,6-,3,4,5- 또는 2,3,6-트리하이드록시페닐이다.Wherein R 1 is o-, m- or p-hydroxyphenyl; 2,3-, 2,4-, 2,5-, 2,6-, 3,4- or 3,5-dihydroxyphenyl; Or 2,3,4-, 2,3,5-, 2,4,5-, 2,4,6-, 3,4,5- or 2,3,6-trihydroxyphenyl. 제1항에 있어서, 올레핀계 이중결합이 트랜스형태인 화합물.The compound of claim 1, wherein the olefinic double bond is in trans form. p-[(E)-2-(5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프틸)프로페닐]페놀.p-[(E) -2- (5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl] phenol. m-[(E)-2-(5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프틸)프로페닐]페놀.m-[(E) -2- (5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl] phenol. o-[(E)-2-(5,6,7,8-테트라하이드로-5,5,8,8-테트라메틸-2-나프틸)프로페닐]페놀.o-[(E) -2- (5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) propenyl] phenol. 약제용으로서의 일반식(Ⅰ)화합물.General formula (I) compound as a pharmaceutical use. 일반식(II)의 화합물로부터 보호그룹(들)을 분리시킴을 포함하는 제1항의 일반식(I)화합물의 제조방법.A process for preparing the compound of formula (I) according to claim 1 which comprises separating the protecting group (s) from the compound of formula (II). 상기식에서, R11은 하이드록시그룹이 보호된 잔기 R1이다.Wherein R 11 is the residue R 1 in which the hydroxy group is protected. 일반식(Ⅰ)의 화합물 및 약제학적 담체를 함유하는 약제학적 제제.A pharmaceutical formulation containing a compound of formula (I) and a pharmaceutical carrier. 신생물(neoplasm) 및 피부병 치료용 약제학적 제제를 제조하기 위한 일반식 (Ⅰ)화합물의 용도.Use of a compound of formula (I) to prepare a pharmaceutical formulation for the treatment of neoplasms and skin diseases. 제7항의 방법 또는 그의 화학적 당량법에 의해 제조된 일반식(Ⅰ)의 화합물.A compound of formula (I) prepared by the method of claim 7 or a chemical equivalent thereof. 전술한 신규 화합물 제제 및 방법.Novel Compound Formulations and Methods as described above. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR870004688A 1986-05-13 1987-05-13 Tetrahydro naphthalene derivative and preparation method thereof KR870011073A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1938/86A CH668962A5 (en) 1986-05-13 1986-05-13 New hydroxy:phenyl:propenyl substd. naphthalene cpds.
CH1938/86 1986-05-13

Publications (1)

Publication Number Publication Date
KR870011073A true KR870011073A (en) 1987-12-19

Family

ID=4222110

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870004688A KR870011073A (en) 1986-05-13 1987-05-13 Tetrahydro naphthalene derivative and preparation method thereof

Country Status (6)

Country Link
JP (1) JPS62267245A (en)
KR (1) KR870011073A (en)
CH (1) CH668962A5 (en)
CS (1) CS265240B2 (en)
GR (1) GR870728B (en)
ZA (1) ZA873244B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340955C (en) * 1988-02-24 2000-04-11 Michael Klaus Stilbene derivatives
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives

Also Published As

Publication number Publication date
GR870728B (en) 1987-09-21
CH668962A5 (en) 1989-02-15
CS331887A2 (en) 1988-12-15
CS265240B2 (en) 1989-10-13
ZA873244B (en) 1987-11-17
JPS62267245A (en) 1987-11-19

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