KR870008831A - Process for preparing phenol ether - Google Patents

Process for preparing phenol ether Download PDF

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Publication number
KR870008831A
KR870008831A KR1019860002409A KR860002409A KR870008831A KR 870008831 A KR870008831 A KR 870008831A KR 1019860002409 A KR1019860002409 A KR 1019860002409A KR 860002409 A KR860002409 A KR 860002409A KR 870008831 A KR870008831 A KR 870008831A
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South Korea
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formula
compound
branched
alkyl
phenyl
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KR1019860002409A
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Korean (ko)
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KR950002832B1 (en
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마우리스 이폴리토 로버트
비그몬드 스테펜
비그몬드 스토테펜
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토르칸 케미칼 리미티드
루돌프 쿠베라
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Priority to KR1019860002409A priority Critical patent/KR950002832B1/en
Publication of KR870008831A publication Critical patent/KR870008831A/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음No content

Description

페놀 에테르의 제조 방법Process for preparing phenol ether

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (14)

하기식(Ⅳ)의 화합물을 산가수분해시키고 필요하다면 이것으로부터 바람직한 약학적 허용염을 제조함으로써 하기식 (Ⅰ)의 페놀 에테르 또는 이것의 약학적 허용 염을 제조하는 방법.A process for producing a phenol ether of formula (I) or a pharmaceutically acceptable salt thereof by acid hydrolysis of a compound of formula (IV) and, if necessary, from a desired pharmaceutically acceptable salt thereof. 상기식에서 m은 2-5의 정수, n은 1-4의 정수, R은 3 또는 4 탄소수의 측쇄알킬 또는 3 또는 4 탄소수의 시클로 알킬이며, R1는 아릴, 치환된 아릴, 직쇄 사슬 또는 측쇄 C2-C11알킬이다.Wherein m is an integer of 2-5, n is an integer of 1-4, R is branched alkyl of 3 or 4 carbon atoms or cycloalkyl of 3 or 4 carbon atoms, R 1 is aryl, substituted aryl, straight chain or branched chain C 2 -C 11 alkyl. 제 1 항에 있어서, R은 2-프로필, m은 2, n은 1, R1은 페닐, 저급 알킬 치환 페닐 또는 직쇄 사슬 또는 측쇄 C2-C11알킨인 것을 특징으로 하는 방법.2. The method of claim 1, wherein R is 2-propyl, m is 2, n is 1, R 1 is phenyl, lower alkyl substituted phenyl or a straight chain or branched C 2 -C 11 alkyne. 제 2 항에 있어서, R1은 페닐인 것을 특징으로 하는 방법.The method of claim 2, wherein R 1 is phenyl. 제 1 항에 있어서, 염기 조건하에서 하기식 (Ⅲ)의 화합물을The compound of formula (III) according to claim 1, wherein 인 시클로 알킬 카르비닐 할라이드와 반응시켜 식 (Ⅳ)의 화합물을 제조하는 것을 특징으로 하는 방법.Reacting with phosphorus cycloalkyl carvinyl halides to produce the compound of formula (IV). 상기식에서 X는 할로겐으로 바람직하게는 염소, 브롬 또는 요오드이다.Wherein X is halogen, preferably chlorine, bromine or iodine. 제 4 항에 있어서, R은 2-프로필, m은 2, n은 1, R1는 페닐, 저급 알킬 치환 페닐 또는 직쇄 사슬 또는 측쇄 C2-C11알킬인 것을 특징으로 하는 방법.5. The process of claim 4, wherein R is 2-propyl, m is 2, n is 1, R 1 is phenyl, lower alkyl substituted phenyl or straight chain or branched C 2 -C 11 alkyl. 제 5 항에 있어서, R1은 페닐인 것을 특징으로 하는 방법.6. The method of claim 5 wherein R 1 is phenyl. 제 4 항에 있어서, 식 (Ⅱ)의 화합물을 R1-CHO(R1는 아릴, 치환 아릴, 또는 직쇄 사슬 또는 측쇄 C2-C11알킬이다)인 알데하이드와 반응시켜 식 (Ⅲ)의 화합물을 제조하는 방법.The compound of formula (III) according to claim 4, wherein the compound of formula (II) is reacted with an aldehyde which is R 1 -CHO (R 1 is aryl, substituted aryl, or straight chain or branched C 2 -C 11 alkyl). How to prepare. 제 7 항에 있어서, R은 2-프로필을 나타내는 것을 특징으로 하는 방법.8. The method of claim 7, wherein R represents 2-propyl. 제 8 항에 있어서, R1는 페닐인 것을 특징으로 하는 방법.9. The method of claim 8, wherein R 1 is phenyl. 제 7 항에 있어서, 식 (Ⅰ)의 화합물을 일차아민 R.NH2(R은 3-4 탄소수의 측쇄알킬 또는 3-4 탄소수의 시클로알킬이다)과 반응시켜 식 (Ⅱ)의 화합물을 제조하는 방법.The compound of formula (II) according to claim 7, wherein the compound of formula (I) is reacted with primary amine R.NH 2 (R is branched alkyl of 3-4 carbon atoms or cycloalkyl of 3-4 carbon atoms). How to. 제 10 항에 있어서, R은 2-프로필인 것을 특징으로 하는 방법.The method of claim 10, wherein R is 2-propyl. 제 10 항에 있어서, 하기식 (Ⅰ)의 화합물은 염기 조건하에서 p-히드록시페네틸 알코올을 에피할로 히드린과 반응시켜 제조하는 것을 특징으로 하는 방법.The method of claim 10, wherein the compound of formula (I) is prepared by reacting p-hydroxyphenethyl alcohol with epihalo hydrin under basic conditions. 하기식 (Ⅲ)의 화합물을Compound of the following formula (III) (여기서, X는 염소, 불소 또는 요오드이다.)인 시클로알킬 카르비닐 할라이드와 반응시켜 하기식 (Ⅳ)의 옥사졸리딘 페놀에테르 화합물을 제조하는 방법.A method for producing an oxazolidine phenolether compound of formula (IV) by reacting with a cycloalkyl carvinyl halide, wherein X is chlorine, fluorine or iodine. 하기식 (Ⅱ)의 화합물을 R1-CHO의 알데하이드와 반응시켜 기하식(Ⅲ)의 옥사졸리딘 페놀 알코올 화합물을 제조하는 방법.A method for producing an oxazolidine phenol alcohol compound of the formula (III) by reacting a compound of formula (II) with an aldehyde of R 1 -CHO. 상기식에서 R은 3-4 탄소수의 측쇄알킬 또는 3-4 탄소수의 시클로 알킬, R1는 아릴, 치환 아릴, 또는 직쇄 사슬 또는 측쇄 C2-C11알킬이다.Wherein R is branched alkyl of 3-4 carbon atoms or cycloalkyl of 3-4 carbon atoms, R 1 is aryl, substituted aryl, or straight chain or branched C 2 -C 11 alkyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860002409A 1986-03-31 1986-03-31 Process for the preparation of phenol ethers KR950002832B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860002409A KR950002832B1 (en) 1986-03-31 1986-03-31 Process for the preparation of phenol ethers

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Application Number Priority Date Filing Date Title
KR1019860002409A KR950002832B1 (en) 1986-03-31 1986-03-31 Process for the preparation of phenol ethers

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KR870008831A true KR870008831A (en) 1987-10-21
KR950002832B1 KR950002832B1 (en) 1995-03-27

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