KR870006075A - Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono [2- (trimethylamino) ethyl] -ester - Google Patents

Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono [2- (trimethylamino) ethyl] -ester Download PDF

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Publication number
KR870006075A
KR870006075A KR1019850009154A KR850009154A KR870006075A KR 870006075 A KR870006075 A KR 870006075A KR 1019850009154 A KR1019850009154 A KR 1019850009154A KR 850009154 A KR850009154 A KR 850009154A KR 870006075 A KR870006075 A KR 870006075A
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KR
South Korea
Prior art keywords
formula
trihydrogendiphosphate
trimethylamino
mono
ethyl
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KR1019850009154A
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Korean (ko)
Inventor
최성관
정갑택
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임병학
미원 주식회사
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Priority to KR1019850009154A priority Critical patent/KR870006075A/en
Publication of KR870006075A publication Critical patent/KR870006075A/en

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Abstract

내용 없음No content

Description

사이티딘-5'-(트리하이드로젠디포스페이트)-모노-[2-(트리메틸아미노)에틸]-에스테르의 제조방법Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono- [2- (trimethylamino) ethyl] -ester

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

구조식(Ⅳ)의 콜린디클로로 포스페이트와 구조식(V)의 사이티딘-5'-모노포스페이트를 반응시켜 구조식(I)의 사이티딘-5'-(트리하이드로젠디포스페이트)-모노-[2-(트리메틸아미노)에틸]-에스테르를 제조함에 있어서, 구조식(Ⅱ)의 콜린클로라이드와 알카리금속을 반응시켜 다음 구조식(Ⅲ)의 화합물을 제조하고 이어서 구조식(Ⅲ) 화합물과 3염화 포스포릴을 반응시켜 구조식(Ⅳ)의 콜린디클로로포스페이트를 제조함을 특징으로 하는 사이티딘-5'-(트리하이드로젠디포스페이트)-모노-[2-(트리메틸아미노)에틸]에스테르의 제조방법.Reaction of cholinedichloro phosphate of formula (IV) with cytidine-5'-monophosphate of formula (V) to react cytidine-5 '-(trihydrogendiphosphate) -mono- [2- ( In preparing trimethylamino) ethyl] -ester, the choline chloride of formula (II) is reacted with an alkali metal to prepare a compound of formula (III), followed by reacting a compound of formula (III) with phosphoryl trichloride. A process for producing cytidine-5 '-(trihydrogendiphosphate) -mono- [2- (trimethylamino) ethyl] ester characterized by preparing cholinedichlorophosphate of (IV). 상기 구조식(Ⅲ)에서 M은 알칼리금속임.M in the formula (III) is an alkali metal. 제1항에 있어서, 구조식(Ⅲ)화합물과 3염화 포스포린을 디메틸포름아미드 용매중에서 반응시키는 방법.The process according to claim 1, wherein the compound of formula III and phosphoric trichloride are reacted in a dimethylformamide solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850009154A 1985-12-05 1985-12-05 Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono [2- (trimethylamino) ethyl] -ester KR870006075A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019850009154A KR870006075A (en) 1985-12-05 1985-12-05 Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono [2- (trimethylamino) ethyl] -ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850009154A KR870006075A (en) 1985-12-05 1985-12-05 Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono [2- (trimethylamino) ethyl] -ester

Publications (1)

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KR870006075A true KR870006075A (en) 1987-07-09

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Application Number Title Priority Date Filing Date
KR1019850009154A KR870006075A (en) 1985-12-05 1985-12-05 Method for preparing cytidine-5 '-(trihydrogendiphosphate) -mono [2- (trimethylamino) ethyl] -ester

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KR (1) KR870006075A (en)

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