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구조식(Ⅳ)의 콜린디클로로 포스페이트와 구조식(V)의 사이티딘-5'-모노포스페이트를 반응시켜 구조식(I)의 사이티딘-5'-(트리하이드로젠디포스페이트)-모노-[2-(트리메틸아미노)에틸]-에스테르를 제조함에 있어서, 구조식(Ⅱ)의 콜린클로라이드와 알카리금속을 반응시켜 다음 구조식(Ⅲ)의 화합물을 제조하고 이어서 구조식(Ⅲ) 화합물과 3염화 포스포릴을 반응시켜 구조식(Ⅳ)의 콜린디클로로포스페이트를 제조함을 특징으로 하는 사이티딘-5'-(트리하이드로젠디포스페이트)-모노-[2-(트리메틸아미노)에틸]에스테르의 제조방법.Reaction of cholinedichloro phosphate of formula (IV) with cytidine-5'-monophosphate of formula (V) to react cytidine-5 '-(trihydrogendiphosphate) -mono- [2- ( In preparing trimethylamino) ethyl] -ester, the choline chloride of formula (II) is reacted with an alkali metal to prepare a compound of formula (III), followed by reacting a compound of formula (III) with phosphoryl trichloride. A process for producing cytidine-5 '-(trihydrogendiphosphate) -mono- [2- (trimethylamino) ethyl] ester characterized by preparing cholinedichlorophosphate of (IV).상기 구조식(Ⅲ)에서 M은 알칼리금속임.M in the formula (III) is an alkali metal.제1항에 있어서, 구조식(Ⅲ)화합물과 3염화 포스포린을 디메틸포름아미드 용매중에서 반응시키는 방법.The process according to claim 1, wherein the compound of formula III and phosphoric trichloride are reacted in a dimethylformamide solvent.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.