KR870005997A - Process for preparing substituted 2-pyridinesulfonamide 1-oxide compound - Google Patents

Abstract

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Description

Process for preparing substituted 2-pyridinesulfonamide 1-oxide compound

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Claims (6)

in a) the following formula (I) compounds of the 2-flute dilseol sulfonyl after an N- oxide as an oxidizing agent, if necessary, to a group of formula (II) compounds or formula (II) reactive functional derivative of a compound of formula R ¹ is H ( A) N-alkylating the compound; Or b) N-sulfonation of an amine of formula (III) with a compound of formula (IV), and if necessary, then R ¹ is H as a reactive action derivative of a compound of formula (II) or a compound of formula (II) A process for preparing a substituted 2-pyridine sulfonamide 1-oxide compound represented by formula (A) by N-alkylating a compound of formula (A). Wherein n is 0 or 1; t is 0,1,2,3 or 4; R ¹ is hydrogen, unsubstituted or halogenated C _1-8 alkyl, unsubstituted or halogenated C _2-8 alkenyl, C _2-8 alkynyl, C _2-10 alkoxyalkyl or C _2-10 alkylthio Alkyl; R ² is hydrogen or C _1-8 alkyl; W is CH or N; W ¹ is CH or N; Whether W or W ¹ is CH, it may be substituted by Y or Z, respectively, X is hydrogen unsubstituted or halogen substituted C _1-8 alkyl, C _1-8 alkoxy or halogen; Y is unsubstituted or halogenated C _1-8 alkyl, unsubstituted or halogenated C _1-8 alkoxy, C _2-8 alkylthio, C _2-8 alkoxycarbonyl, nitro, cyano or halogen; Z may be each selected from hydrogen or Y, and R ¹ _a is unsubstituted or halogenated C _1-8 alkyl, unsubstituted or halogenated C _2-8 alkenyl, C _2-8 alkynyl, C _2-10 alkoxyalkyl or C _2-10 alkylthioalkyl and Hal is halogen. The compound of claim 1, wherein R ¹ is C _2-5 alkyl, C _2-5 alkenyl or C _2-5 alkynyl; n is 0; t is 0 or 1; X is hydrogen or hydrogen; Z is at position 2 and is C _1-5 alkyl, CF ₃ , halogen or di- or trifluoro-labeled C _1-5 alkoxy; Y is C _1-5 alkyl, CF ₃ , nitro or halogen; W and W ¹ are CH and any one of the CH groups can be substituted by Y when t is 1. 3. A method according to claim 2, wherein Z is fluorine, trifluoromethyl, difluoromethoxy or 2,2,2-trifluoroethoxy and Y is fluoro or chloro (w when t is 1). . 4. A method according to claim 2 or 3, wherein X is hydrogen or fluorine or chlorine at position 5 and Y is at position 6 (when t is 1). 5. The N-methyl-N- (2-trifluoromethylphenyl) -2-pyridinesulfonamide 1-oxide of claim 4. b) N-methyl-N- (2-trifluoromethylphenyl) -5-chloro-2-pyridinesulfonamide 1-oxide. c) N-ethyl-N- (2-trifluoromethylphenyl) -2-pyridinesulfonamide 1-oxide. d) N-ethyl-N- (2-trifluoromethylphenyl) -5-chloro-2-pyridinesulfonamide 1-oxide. e) N-ethyl-N- (2-difluoromethoxyphenyl) -5-chloro-2-pyridinesulfonamide 1-oxide. f) N-methyl-N- [2- (2,2,2-trifluoroethoxy) phenyl] -5-chloro-2-pyridinesulfonamide 1-oxide. g) a process for preparing a compound selected from N-ethyl-N- (2,6-difluorophenyl) -5-chloro-2-pyridinesulfonamide 1-oxide and the like. The method of claim 4, wherein a) N-methyl-N- (2,6-difluorophenyl) -5-fluoro-2-pyridinesulfonamide 1-oxide. b) N-methyl-N- (2-fluoro-6-chlorophenyl) -5-fluoro-2-pyridinesulfonamide1-oxide. c) N-methyl-N- (2-fluoromethoxyphenyl) -5-fluoro-2-pyridinesulfonamide 1-oxide. d) a process for preparing a compound selected from N-methyl-N- [2 (2,2,2-trifluoroethoxyphenyl) -5-fluoro-2-pyridine sulfonamide 1-oxide and the like. ※ Note: The disclosure is based on the initial application.