KR870004988A - 결정성 세팔로스포린 일수화물의 제조방법 - Google Patents
결정성 세팔로스포린 일수화물의 제조방법 Download PDFInfo
- Publication number
- KR870004988A KR870004988A KR860009269A KR860009269A KR870004988A KR 870004988 A KR870004988 A KR 870004988A KR 860009269 A KR860009269 A KR 860009269A KR 860009269 A KR860009269 A KR 860009269A KR 870004988 A KR870004988 A KR 870004988A
- Authority
- KR
- South Korea
- Prior art keywords
- monohydrate
- preparing crystalline
- cepem
- pyridiniummethyl
- crystalline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 구조식(2)의 화합물의 디하이드로클로라이드 이수화합물을 -40℃ 내지 0℃에서 에탄올/메틸렌 클로라이드 용매계에 현탁시킨후 염기를 가함을 특징으로 하여, 결정성(7R)-7-아미노-3-(1'-피리디늄메틸)-3-세펨-4-카복실레이트 일수화물을 제조하는 방법.
- 제1항에 있어서, λ=1.541의 닉켈-여과된 구리방사선을 사용하여 수득된 하기의 X-레이분말 회절선을 갖는 결정성 7-(R)-아미노-3-(1'-피리디늄메틸)-3-세펨-4-카복실레이트 일수화물을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US795,568 | 1985-11-06 | ||
US06/795,568 US4692518A (en) | 1985-11-06 | 1985-11-06 | Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870004988A true KR870004988A (ko) | 1987-06-04 |
KR890004562B1 KR890004562B1 (ko) | 1989-11-15 |
Family
ID=25165853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860009269A KR890004562B1 (ko) | 1985-11-06 | 1986-11-04 | 결정성 세팔로스포린 일수화물 및 이의 제조방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4692518A (ko) |
EP (1) | EP0222577A3 (ko) |
JP (1) | JPS62108883A (ko) |
KR (1) | KR890004562B1 (ko) |
CA (1) | CA1279311C (ko) |
HU (1) | HU195225B (ko) |
IE (1) | IE862910L (ko) |
IL (1) | IL80474A0 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4918067A (en) * | 1986-07-24 | 1990-04-17 | Beecham Group P.L.C. | Heterocyclic substituted penicillin antibiotics |
CN100344635C (zh) * | 2003-07-22 | 2007-10-24 | 广州白云山制药股份有限公司 | 7-苯乙酰氨基-3-吡啶甲基-3-头孢菌素-4-羧酸对甲氧苄酯晶体及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB953695A (en) * | 1959-08-04 | 1964-03-25 | Nat Res Dev | Derivatives of cephalosporin c |
JPS5759760B2 (ko) * | 1974-02-25 | 1982-12-16 | Toyo Jozo Kk | |
AR228726A1 (es) * | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
IT1145686B (it) * | 1979-05-25 | 1986-11-05 | Glaxo Group Ltd | Intermedi per la preparazione di antibiotici cefalosporinici e procedimento per prepararli |
US4540779A (en) * | 1983-06-20 | 1985-09-10 | Eli Lilly And Company | Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound |
-
1985
- 1985-11-06 US US06/795,568 patent/US4692518A/en not_active Expired - Fee Related
-
1986
- 1986-11-03 IL IL80474A patent/IL80474A0/xx not_active IP Right Cessation
- 1986-11-03 CA CA000522009A patent/CA1279311C/en not_active Expired - Lifetime
- 1986-11-03 EP EP86308556A patent/EP0222577A3/en not_active Ceased
- 1986-11-04 KR KR1019860009269A patent/KR890004562B1/ko not_active IP Right Cessation
- 1986-11-05 HU HU864609A patent/HU195225B/hu unknown
- 1986-11-05 IE IE862910A patent/IE862910L/xx unknown
- 1986-11-05 JP JP61264873A patent/JPS62108883A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0222577A3 (en) | 1988-10-05 |
HUT42490A (en) | 1987-07-28 |
IL80474A0 (en) | 1987-02-27 |
JPS62108883A (ja) | 1987-05-20 |
EP0222577A2 (en) | 1987-05-20 |
US4692518A (en) | 1987-09-08 |
KR890004562B1 (ko) | 1989-11-15 |
HU195225B (en) | 1988-04-28 |
CA1279311C (en) | 1991-01-22 |
IE862910L (en) | 1987-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19921002 Year of fee payment: 4 |
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LAPS | Lapse due to unpaid annual fee |