KR870003971A - Method for preparing 1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol - Google Patents

Method for preparing 1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol Download PDF

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Publication number
KR870003971A
KR870003971A KR1019850007520A KR850007520A KR870003971A KR 870003971 A KR870003971 A KR 870003971A KR 1019850007520 A KR1019850007520 A KR 1019850007520A KR 850007520 A KR850007520 A KR 850007520A KR 870003971 A KR870003971 A KR 870003971A
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KR
South Korea
Prior art keywords
general formula
carbamoylmethylphenoxy
isopropylamino
propanol
preparing
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Application number
KR1019850007520A
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Korean (ko)
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KR890002163B1 (en
Inventor
유응걸
한정식
Original Assignee
채영복
재단법인 한국화학연구소
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Priority to KR1019850007520A priority Critical patent/KR890002163B1/en
Publication of KR870003971A publication Critical patent/KR870003971A/en
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Publication of KR890002163B1 publication Critical patent/KR890002163B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

1-p-카르바모일메틸페녹시-3-이소프로필아미노-2-프로판올의 제조방법.Method for preparing 1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

p-히드록시페닐아세트 아미드와 에피클로로히드린 및 이소프로필아민과 반응시켜 1-p-카르바모일메틸페녹시-3-이소프로필아미노-2-프로판올을 제조함에 있어서, 하기 일반식(Ⅱ)의 p-히드록시페닐 아세트아미드를 일반식 M(OH)(식중, M은 나트륨, 칼륨)의 수용액에 용해시키고 에피클로로히드린과 반응시켜 일반식(Ⅱ)의 1-p-카르바모일메틸페녹시-2,3-에폭시프로판을 얻고, 이를 분리 또는 분리하지 않은 상태로 이소프로필아민과 반응시켜 하기 일반식(Ⅰ)의 1-p-카르바모일메틸페녹시-3-이소프로필아미노-2-프로판올의 제조방법.In preparing 1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol by reacting p-hydroxyphenylacetamide with epichlorohydrin and isopropylamine, the following general formula (II) P-hydroxyphenyl acetamide was dissolved in an aqueous solution of general formula M (OH) (wherein M is sodium and potassium) and reacted with epichlorohydrin to yield 1-p-carbamoylmethyl of general formula (II). Obtaining phenoxy-2,3-epoxypropane, reacted with isopropylamine in the state of separating or not separating 1-p-carbamoylmethylphenoxy-3-isopropylamino- of the general formula (I) Method for preparing 2-propanol. 제1항에 있어서, 일반식 M(OH)의 양이 p-히드록시페닐아세트아미드의 양에 대하배 1-2배 몰양을 사용함을 특징으로 하는 방법.The method according to claim 1, wherein the amount of general formula M (OH) is used in a molar amount of 1-2 times the amount of p-hydroxyphenylacetamide. 제1항에 있어서, 에피클로로히드린과의 반응온도가 10-60℃인 것이 특징인 방법.The method according to claim 1, wherein the reaction temperature with epichlorohydrin is 10-60 ° C. 제1항에 있어서, 일반식(Ⅲ) 화합물과 이소프로필아민올 40-90℃에서 반응시킴을 특징으로 하는 방법.The process according to claim 1, wherein the compound of formula (III) is reacted with isopropylamineol at 40-90 ° C. 제1항에 있어서, 용매로서 물을 사용하는 것이 특징인 방법.The method of claim 1 wherein water is used as the solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850007520A 1985-10-12 1985-10-12 Process for the preparation of 1-p-carbamoyl-methylphenoxy-3-isopropylamino-2-propaneol KR890002163B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019850007520A KR890002163B1 (en) 1985-10-12 1985-10-12 Process for the preparation of 1-p-carbamoyl-methylphenoxy-3-isopropylamino-2-propaneol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850007520A KR890002163B1 (en) 1985-10-12 1985-10-12 Process for the preparation of 1-p-carbamoyl-methylphenoxy-3-isopropylamino-2-propaneol

Publications (2)

Publication Number Publication Date
KR870003971A true KR870003971A (en) 1987-05-06
KR890002163B1 KR890002163B1 (en) 1989-06-21

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Application Number Title Priority Date Filing Date
KR1019850007520A KR890002163B1 (en) 1985-10-12 1985-10-12 Process for the preparation of 1-p-carbamoyl-methylphenoxy-3-isopropylamino-2-propaneol

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Publication number Publication date
KR890002163B1 (en) 1989-06-21

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