KR860007381A - 광학활성 α-아릴알칸산의 생물공학적 제조방법 - Google Patents

광학활성 α-아릴알칸산의 생물공학적 제조방법 Download PDF

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KR860007381A
KR860007381A KR1019860001932A KR860001932A KR860007381A KR 860007381 A KR860007381 A KR 860007381A KR 1019860001932 A KR1019860001932 A KR 1019860001932A KR 860001932 A KR860001932 A KR 860001932A KR 860007381 A KR860007381 A KR 860007381A
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formula
microorganism
ester
esterase
arylalkanoic acid
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KR1019860001932A
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체스띠 피에뜨로
피카르디 파올로
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루이지 꼬띠
몬테디손 에스.페.아.
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Publication of KR860007381A publication Critical patent/KR860007381A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

광학활성 α-아릴알칸산의 생물공학적 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 다음식(I)-아릴알칸산의 라세믹(R,S)에스 테르와 식 (I)의 라세믹에스테르의 S(+)형태를 우세하게 비대칭적으로 가수분해할 수 있는 미생물에 의해 제조된 에스테라제를 반응시킨 다음, 반응하지 않은 에스테르, 실질적으로 R(-) 형태중에서 실질적으로 얻어진 S(+)형태의 산을 공지된 기술로 분리함을 특징으로 하는 실질적으로 S(+)광학이성체형태의-아릴알칸산의 생물공학적 제조방법.
    상기 식에서,
    R은 -C=CH, -CH=CH2, -CN, -COCH3, -COO알킬(C1-C4), 또는 -CH2-O-알킬(C1-C4)을 나타내고；
    Ar은 알릴 또는 다른 기로 치환되거나 또는 축합된 아릴을 나타낸다.
  2. 제1항에 있어서, 식(I)의 에스테르중에서 Ar은 다음식(Ⅱ) 또는 (Ⅲ)의 기를 나타냄을 특징으로 하는 방법.
    상기 식에서, R은 C1내지 C8을 갖는 직쇄 또는 측쇄 알킬, C1내지 C4를 갖는 알케닐, 알콕시, 페닐페녹시, 테노일 또는 헤테로고리이고；
    R"은 수소 또는 할로겐원자이고；R"'은 C1내지 C4를 함유하는 알킬이다.
  3. 제1항에 있어서, 에스테라제가 미생물에 의해 제조된 칸디다 실린드라세아 리파아제임을 특징으로 하는 방법.
  4. 제1항에 있어서, 에스테라제가 미생물의 세포, 미생물의 배양액체, 또는 미생물의 추출액 또는 농축액에 함유됨을 특징으로 하는 방법.
  5. 제1항에 있어서, 비대칭가수분해반응이 pH 5 내지 9에서 수행됨을 특징으로하는 방법.
  6. 제1항에 있어서, 반응온도가 20℃ 내지 40℃임을 특징으로 하는 방법.
  7. 제1항에 있어서, 반응혼합물중의 식(I)의 세라믹에스테르의 농도가 1중량% 내지 20중량%임을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860001932A 1985-03-22 1986-03-17 광학활성 α-아릴알칸산의 생물공학적 제조방법 KR860007381A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20036/85A IT1201408B (it) 1985-03-22 1985-03-22 Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
IT20036A/85 1985-03-22

Publications (1)

Publication Number Publication Date
KR860007381A true KR860007381A (ko) 1986-10-10

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ID=11163308

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KR1019860001932A KR860007381A (ko) 1985-03-22 1986-03-17 광학활성 α-아릴알칸산의 생물공학적 제조방법

Country Status (9)

Country Link
US (1) US4762793A (ko)
EP (1) EP0195717B1 (ko)
JP (1) JPS61239899A (ko)
KR (1) KR860007381A (ko)
AT (1) ATE68210T1 (ko)
DE (1) DE3681810D1 (ko)
ES (1) ES8705842A1 (ko)
HU (1) HU197943B (ko)
IT (1) IT1201408B (ko)

Families Citing this family (26)

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GB8514489D0 (en) * 1985-06-07 1985-07-10 Shell Int Research Producing 2-arylpropionic acids
US5322791A (en) * 1985-12-20 1994-06-21 Wisconsin Alumni Research Foundation Process for preparing (S)-α-methylarylacetic acids
US4897357A (en) * 1985-12-31 1990-01-30 Ethyl Corporation (S) α-cyano-3-phenoxy-benzyl acetate
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
GB8705601D0 (en) * 1987-03-10 1987-04-15 Erba Farmitalia Oxo-isoindolinyl derivatives
GB8715476D0 (en) * 1987-07-01 1987-08-05 Shell Int Research Preparation of ibuprofen
GB8715574D0 (en) * 1987-07-02 1987-08-12 Shell Int Research 2-aryloxypropionic acids
US5229280A (en) * 1988-02-25 1993-07-20 Istituto Guido Donegani S.P.A. Process for the continuous biotechnological preparation of optical isomer s(+) of 2-(6-methoxy-2-naphthyl) propionic acid
US6284492B1 (en) 1988-02-26 2001-09-04 Large Scale Biology Corporation Recombinant animal viral nucleic acids
US5316931A (en) * 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US6054566A (en) 1988-02-26 2000-04-25 Biosource Technologies, Inc. Recombinant animal viral nucleic acids
JPH01228488A (ja) * 1988-03-09 1989-09-12 Fuji Yakuhin Kogyo Kk パントテン酸またはその塩の製造法
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US5266723A (en) * 1989-05-16 1993-11-30 Medice, Ltd., Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids
ZA903759B (en) * 1989-05-16 1991-02-27 Puetter Medice Chem Pharm Process for preparing optically active 2-aryl alkanoic acids,in particular 2-aryl propionic acids
DE3919029A1 (de) * 1989-06-10 1990-12-13 Hoechst Ag Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester
US4921798A (en) * 1989-09-25 1990-05-01 Eastman Kodak Company Synthesis of (aryl or arylalkyl)-3-hydroxy propionic acids and aryl alkanediols having high optical purity
ATE134610T1 (de) * 1991-08-22 1996-03-15 Lonza Ag Verfahren zur herstellung von optisch aktiven 4- amino-3-hydroxycarbonsäuren
DE69325698T2 (de) * 1992-12-21 2000-01-27 Duphar Int Res Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols
GB9304351D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution and microorganisms for use therein
US5912164A (en) * 1993-03-03 1999-06-15 Laboratorios Menarini S.A. Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis
US5457051A (en) * 1993-03-09 1995-10-10 Sepracor, Inc. Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom
US5434302A (en) * 1994-02-18 1995-07-18 Paradies; H. Henrich Method for the preparation of optically active 2-aryl alkyl aldehydes and formation of 2-aryl-alkanoic acids therefrom
US5750764A (en) * 1995-11-17 1998-05-12 Aeci Limited Synthesis and resolution of propionic acid derivatives
US6242243B1 (en) * 1998-03-30 2001-06-05 Council Of Scientific & Industrial Research Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(+)-6-methoxy-methyl-2-naphthalene acetic acid
US6201151B1 (en) * 1998-12-17 2001-03-13 National Science Council Of Republic Of China Processes for preparing optically active (S)-α-aryl propionic acid or ester therof

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AU587366B2 (en) * 1983-07-27 1989-08-17 Imperial Chemical Industries Plc Process for producing optically active aryloxypropionic acids and derivatives thereof

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HU197943B (en) 1989-06-28
ATE68210T1 (de) 1991-10-15
EP0195717A3 (en) 1989-02-22
DE3681810D1 (de) 1991-11-14
JPS61239899A (ja) 1986-10-25
HUT41069A (en) 1987-03-30
IT8520036A0 (it) 1985-03-22
ES553215A0 (es) 1987-05-16
ES8705842A1 (es) 1987-05-16
EP0195717A2 (en) 1986-09-24
EP0195717B1 (en) 1991-10-09
US4762793A (en) 1988-08-09
IT1201408B (it) 1989-02-02

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