KR860004054A - Method for preparing 1- (2-tetrahydrofuryl) -5-fluorouracil - Google Patents

Method for preparing 1- (2-tetrahydrofuryl) -5-fluorouracil Download PDF

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Publication number
KR860004054A
KR860004054A KR1019850008257A KR850008257A KR860004054A KR 860004054 A KR860004054 A KR 860004054A KR 1019850008257 A KR1019850008257 A KR 1019850008257A KR 850008257 A KR850008257 A KR 850008257A KR 860004054 A KR860004054 A KR 860004054A
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KR
South Korea
Prior art keywords
carboxylic acid
fluorouracil
carboxylate
preparing
dihydrofuran
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KR1019850008257A
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Korean (ko)
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KR920006418B1 (en
Inventor
데루오(외 2) 우메모또
Original Assignee
곤도오 기요시
자이단호오 진사 가미쥬 오오 가가꾸겐뀨쇼(외 1)
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Publication of KR860004054A publication Critical patent/KR860004054A/en
Application granted granted Critical
Publication of KR920006418B1 publication Critical patent/KR920006418B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

1-(2-태트라히드로푸릴)-5-플루오로우라실의 제조방법Method for preparing 1- (2-tatrahydrofuryl) -5-fluorouracil

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (6)

카르복실산 존재하의 피리딘내에서 5-플루오로우라실과 2,3-디히드로푸란을 반응시킨후, 수득된 반응용액에 카르복실산염 수용액을 가하여 처리함을 특징으로 하는, 1-(2-테트라히드로푸릴)-5-플루오로우라실의 제조방법.1- (2-tetra), characterized in that 5-fluorouracil and 2,3-dihydrofuran are reacted in pyridine in the presence of carboxylic acid, followed by treatment by adding an aqueous solution of carboxylate to the obtained reaction solution. Method for preparing hydrofuryl) -5-fluorouracil. 제1항에 있어서, 카르복실산 존재하의 80°~180℃의 피리딘내에서 5-플루오로우라실을 2,3-디히드로푸란과 반응시킨후, 수득된 반응용액에 카르복실산염 수용액을 가하고 실온~100℃에서 처리함을 특징으로 하는 방법.The reaction solution of claim 1, wherein 5-fluorouracil is reacted with 2,3-dihydrofuran in pyridine at 80 ° C. to 180 ° C. in the presence of carboxylic acid. The process characterized in that the treatment at ~ 100 ℃. 제1 또는 2항에 있어서, 카르복실산이 저급지방족 카르복실산인 방법.The method of claim 1 or 2, wherein the carboxylic acid is a lower aliphatic carboxylic acid. 제1 또는 2항에 있어서, 카르복실산의 사용량이 5-플루오로우라실에 대하여 0.1~2.5배몰인 방법.The method according to claim 1 or 2, wherein the amount of carboxylic acid used is 0.1 to 2.5 times molar relative to 5-fluorouracil. 제1 또는 2항에 있어서, 카르복실산염이 탄소수 8개이하인 카르복실산 알카리금속염 또는 토금속염인 방법.The method according to claim 1 or 2, wherein the carboxylate is an carboxylic acid alkali metal salt or earth metal salt having 8 or less carbon atoms. 제1 또는 2항에 있어서, 카르복실산염 수용액의 농도가 0.01~10몰농도인 방법.The method according to claim 1 or 2, wherein the concentration of the aqueous solution of carboxylate is 0.01 to 10 molar concentrations. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850008257A 1984-11-06 1985-11-05 Process for the preparation of 1-(2-tetrahydrofuryl)-s-fluorouracil KR920006418B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP232498 1984-11-06
JP59-232498 1984-11-06
JP59232498A JPS61112073A (en) 1984-11-06 1984-11-06 Production of 1-(2-tetrahydrofuryl)-5-fluorouracil

Publications (2)

Publication Number Publication Date
KR860004054A true KR860004054A (en) 1986-06-16
KR920006418B1 KR920006418B1 (en) 1992-08-06

Family

ID=16940264

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850008257A KR920006418B1 (en) 1984-11-06 1985-11-05 Process for the preparation of 1-(2-tetrahydrofuryl)-s-fluorouracil

Country Status (3)

Country Link
JP (1) JPS61112073A (en)
KR (1) KR920006418B1 (en)
CN (1) CN1014893B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004102508A (en) * 2002-09-06 2004-04-02 Renesas Technology Corp Semiconductor storage device
CN102285972A (en) * 2011-08-08 2011-12-21 江苏大学 Process for preparing tegafur
CN107235967B (en) * 2017-07-27 2019-10-15 福州大学 The synthesis technology of anti-tumor drug Tegafur

Also Published As

Publication number Publication date
CN85108855A (en) 1986-09-24
KR920006418B1 (en) 1992-08-06
JPH0430956B2 (en) 1992-05-25
CN1014893B (en) 1991-11-27
JPS61112073A (en) 1986-05-30

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