KR860003010A - Transdermal dosage form - Google Patents

Transdermal dosage form Download PDF

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Publication number
KR860003010A
KR860003010A KR1019840006611A KR840006611A KR860003010A KR 860003010 A KR860003010 A KR 860003010A KR 1019840006611 A KR1019840006611 A KR 1019840006611A KR 840006611 A KR840006611 A KR 840006611A KR 860003010 A KR860003010 A KR 860003010A
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KR
South Korea
Prior art keywords
acrylate
adhesive base
base material
meth
concentration
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Application number
KR1019840006611A
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Korean (ko)
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KR900002337B1 (en
Inventor
무쓰미 후꾸다 (외 4)
Original Assignee
후지누마 모또도시
세끼스이 가가꾸 고교 가부시기 가이샤
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Priority to KR1019840006611A priority Critical patent/KR900002337B1/en
Publication of KR860003010A publication Critical patent/KR860003010A/en
Application granted granted Critical
Publication of KR900002337B1 publication Critical patent/KR900002337B1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음No content

Description

경피 투여형 약제Transdermal dosage form

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 테이프형 약제의 부착 면적과 혈중 ISDN 농도와의 관계를 도식으로 나타낸 것이고,1 is a diagram showing the relationship between the adhesion area of the tape-like drug and the blood ISDN concentration,

제2도는 테이프형 약제의 접착성 기제층의 두께와 ISDN의 피부에로의 전이와의 관계를 도식으로 나타낸 것이며,2 is a diagram showing the relationship between the thickness of the adhesive base layer of the tape-type drug and the transition of ISDN to the skin,

제3도는 테이프형 약제의 접착성 기제층 10㎠당 ISDN 농도와의 관계를 나타낸 것이다.3 shows the relationship with the ISDN concentration per 10 cm 2 of the adhesive base layer of the tape-type drug.

Claims (6)

활성성분이 침투되지 않는 유연성 백킹 및 이유연성 백킹상에 형성된, 45% 이상의 농도의 2-에틸헥실 아크릴레이트(EHA)와 20 내지 55몰% 농도의 N-비닐-2-피롤리돈(VP)을 함유한 코폴리머인 접착성 기제물질과 이 접착성 기제물질과 양립성을 가지며, 접착성 기제물질에 10중량% 이상의 농도로 함유되는 이소소르비드 디니트레이트(ISDN)활성성분으로 구성되는 접착성 기제층으로 이루어짐을 특징으로하는 테이프 형태의 경피 투여형 약제.At least 45% 2-ethylhexyl acrylate (EHA) and 20-55 mol% N-vinyl-2-pyrrolidone (VP) formed on flexible backing and non-flammable backing that do not penetrate the active ingredient Adhesive base material, which is a copolymer containing, is compatible with the adhesive base material, and is composed of isosorbide dinitrate (ISDN) active ingredient contained in the adhesive base material at a concentration of 10% by weight or more. A transdermal dosage form drug in the form of a tape, characterized in that it consists of a base layer. 제1항에 있어서, 접착성 기제물질이 55몰 % 이상의 농도의 EHA와 30 내지 45몰% 농도의 VP를 함유하는 코폴리머이고, 접착성 기제물질내의 ISDN의 농도는 13중량% 이상인 약제.The agent according to claim 1, wherein the adhesive base is a copolymer containing 55 mole% or more of EHA and 30 to 45 mole% of VP, and the concentration of ISDN in the adhesive base is 13% by weight or more. 제1항에 있어서, 접착성 기제물질이 프로필 아크릴레이트, 부틸 아크릴레이트, 헥실 아크릴레이트, 2-에틸 부틸 아크릴레이트, 헥실 아크릴레이트, 2-에틸부틸 아크릴레이트, 헵틸 아크릴레이트, 옥틸 아크릴레이트, 노닐 아크릴레이트, 데실메타아크릴레이트 및 라우틸 메타아크릴레이트에서 하나 이상 선택된(메타) 아크릴레이트 모노머를 코폴리머성분으로서 35몰% 이하의 농도로 추가로 함유하는 약제.The method of claim 1 wherein the adhesive base material is propyl acrylate, butyl acrylate, hexyl acrylate, 2-ethyl butyl acrylate, hexyl acrylate, 2-ethylbutyl acrylate, heptyl acrylate, octyl acrylate, nonyl A medicament further comprising (meth) acrylate monomers selected from at least one of acrylates, decylmethacrylates and lauryl methacrylates at a concentration of up to 35 mole percent as a copolymer component. 제2항에 있어서, 접착성 기제물질이 프로필 아크릴레이트, 부틸아크릴레이크, 헥실아크릴레이트, 2-에틸부틸아크릴레이트, 헵틸 아크릴레이트,옥틸아크릴레이트, 노닐아크릴레이트, 데실 메타아크릴레이트 및 라우릴 메타아크릴레이트에서 하나이상 선택된(메타)아크릴레이트 모노머를 코폴리머성붐으로서 15몰% 이하의 농도로 함유하는 약제.The method of claim 2 wherein the adhesive base material is propyl acrylate, butyl acrylate, hexyl acrylate, 2-ethylbutyl acrylate, heptyl acrylate, octyl acrylate, nonyl acrylate, decyl methacrylate and lauryl meta A medicament containing at least 15 mole% of a (meth) acrylate monomer selected from acrylates as a copolymeric boom. 제1항 내지 제4항중 어느 하나에 있어서, 접착성 기제물질이 다작용성모노머를 모노머 총량의 0.005 내지 0.5중량%의 농도로 함유하는 코폴리머인 약제.The agent according to any one of claims 1 to 4, wherein the adhesive base material is a copolymer containing the polyfunctional monomer at a concentration of 0.005 to 0.5% by weight of the total amount of the monomer. 제5항에 있어서, 다작용성 모노머가디(메타) 아크릴레이트, 트리(메타) 아크릴 레이트 및 테트라(메타)아크릴 레이트에서 하나 이상 선택된 약제.The agent according to claim 5, wherein the multifunctional monomer is at least one selected from di (meth) acrylate, tri (meth) acrylate and tetra (meth) acrylate. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840006611A 1984-10-24 1984-10-24 Percutaneous administration type pharmaceutical preparation KR900002337B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840006611A KR900002337B1 (en) 1984-10-24 1984-10-24 Percutaneous administration type pharmaceutical preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840006611A KR900002337B1 (en) 1984-10-24 1984-10-24 Percutaneous administration type pharmaceutical preparation

Publications (2)

Publication Number Publication Date
KR860003010A true KR860003010A (en) 1986-05-19
KR900002337B1 KR900002337B1 (en) 1990-04-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840006611A KR900002337B1 (en) 1984-10-24 1984-10-24 Percutaneous administration type pharmaceutical preparation

Country Status (1)

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KR (1) KR900002337B1 (en)

Also Published As

Publication number Publication date
KR900002337B1 (en) 1990-04-12

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