WO2002060417A8 - Binding agent which is stable in storage and used for pharmaceutical applications - Google Patents

Binding agent which is stable in storage and used for pharmaceutical applications

Info

Publication number
WO2002060417A8
WO2002060417A8 PCT/EP2001/000923 EP0100923W WO02060417A8 WO 2002060417 A8 WO2002060417 A8 WO 2002060417A8 EP 0100923 W EP0100923 W EP 0100923W WO 02060417 A8 WO02060417 A8 WO 02060417A8
Authority
WO
WIPO (PCT)
Prior art keywords
binding agent
acrylate
meth
stable
storage
Prior art date
Application number
PCT/EP2001/000923
Other languages
German (de)
French (fr)
Other versions
WO2002060417A1 (en
Inventor
Hans-Ulrich Petereit
Manfred Assmus
Thomas Beckert
Guenther Bergmann
Stephanie Zacharias
Original Assignee
Roehm Gmbh
Hans-Ulrich Petereit
Manfred Assmus
Thomas Beckert
Guenther Bergmann
Stephanie Zacharias
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Gmbh, Hans-Ulrich Petereit, Manfred Assmus, Thomas Beckert, Guenther Bergmann, Stephanie Zacharias filed Critical Roehm Gmbh
Priority to US10/239,187 priority Critical patent/US20050019381A1/en
Priority to PCT/EP2001/000923 priority patent/WO2002060417A1/en
Priority to JP2002560610A priority patent/JP2004517157A/en
Priority to DE20180358U priority patent/DE20180358U1/en
Publication of WO2002060417A1 publication Critical patent/WO2002060417A1/en
Publication of WO2002060417A8 publication Critical patent/WO2002060417A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/28—Non-macromolecular organic substances
    • C08L2666/34—Oxygen-containing compounds, including ammonium and metal salts

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a binding agent for dermal or transdermal therapeutic systems. Said binding agent comprises (a) a (meth)acrylate copolymer consisting of radically polymerised C1 to C4 alkyl esters of acrylic or methacrylic acid and (meth)acrylate monomers with a cationic ammonium group in the alkyl radical, containing (b) between 0.1 and 45 wt. %, in relation to (a), of an organic dicarboxylic acid or tricarboxylic acid or an acrylate or (meth)acrylate polymer or copolymer containing acid groups, and (c) between 20 and 80 wt. %, in relation to (a), of a plasticizer, and (d) optionally a pharmaceutical active ingredient and/or pharmaceutically standard additives. The invention is characterised in that the plasticizer used is dibutyl sebacate.
PCT/EP2001/000923 2001-01-29 2001-01-29 Binding agent which is stable in storage and used for pharmaceutical applications WO2002060417A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/239,187 US20050019381A1 (en) 2001-01-29 2001-01-29 Binding agent which is stable in storage and used for pharmaceutical applications
PCT/EP2001/000923 WO2002060417A1 (en) 2001-01-29 2001-01-29 Binding agent which is stable in storage and used for pharmaceutical applications
JP2002560610A JP2004517157A (en) 2001-01-29 2001-01-29 Storage-stable adhesives and binders for pharmaceutical applications
DE20180358U DE20180358U1 (en) 2001-01-29 2001-01-29 Storage-stable adhesive and binder for pharmaceutical applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/000923 WO2002060417A1 (en) 2001-01-29 2001-01-29 Binding agent which is stable in storage and used for pharmaceutical applications

Publications (2)

Publication Number Publication Date
WO2002060417A1 WO2002060417A1 (en) 2002-08-08
WO2002060417A8 true WO2002060417A8 (en) 2002-12-05

Family

ID=8164264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/000923 WO2002060417A1 (en) 2001-01-29 2001-01-29 Binding agent which is stable in storage and used for pharmaceutical applications

Country Status (4)

Country Link
US (1) US20050019381A1 (en)
JP (1) JP2004517157A (en)
DE (1) DE20180358U1 (en)
WO (1) WO2002060417A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10220470A1 (en) * 2002-04-30 2003-11-20 Roehm Gmbh ph-sensitive polymer
DE19961334A1 (en) * 1999-12-17 2001-06-21 Roehm Gmbh Injection molding process for neutral and acid group-containing (meth) acrylate copolymers
DE10127134A1 (en) * 2001-06-05 2002-12-12 Roehm Gmbh Production of injection molded shaped articles, especially for retarded drug release, by blending (meth)acrylate copolymer with plasticizer and other additives, degassing and molding
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
US7005031B2 (en) * 2002-01-16 2006-02-28 3M Innovative Properties Company Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods
DE10208335A1 (en) * 2002-02-27 2003-09-04 Roehm Gmbh Pharmaceutical form and process for its preparation
DE10250543A1 (en) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Multilayer dosage form
MXPA04010956A (en) 2003-01-30 2005-01-25 Roehm Gmbh Pharmaceutical dosage form and method for the production thereof.
DE102007060175A1 (en) * 2007-12-13 2009-06-18 Johannes Gutenberg-Universität Mainz Quaternization of the additive aminoalkyl methacrylate copolymer E to improve the permeability and solubility of drugs
WO2011012161A1 (en) * 2009-07-30 2011-02-03 Evonik Röhm Gmbh Powdery or granulated composition comprising a copolymer, a dicarboxylic acid and a fatty monocarboxylic acid
CN105419206B (en) * 2009-07-30 2017-12-15 赢创罗姆有限公司 Powdered or granular composition comprising copolymer, dicarboxylic acids and aliphatic mono-carboxylic acids
EP2550863A1 (en) 2011-07-27 2013-01-30 Bayer Intellectual Property GmbH Particles on a polyacrylate basis containing active materials

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4026992A1 (en) * 1990-08-25 1992-02-27 Roehm Gmbh PROCESS FOR THE PRODUCTION OF SUPPORT SYSTEMS FOR BIOLOGICAL ACTIVE MATERIALS
DE4310012A1 (en) * 1993-03-27 1994-09-29 Roehm Gmbh Dermal therapeutic system made of a meltable poly (meth) acrylate mixture
US6211425B1 (en) * 1996-10-04 2001-04-03 Saitama Daiichi Seiyaku Kabushiki Kaisha Patch
DE19653605C2 (en) * 1996-12-20 2002-11-28 Roehm Gmbh Adhesives and binders for dermal or transdermal therapy systems and their use for producing a transdermal therapy system
DE19653606A1 (en) * 1996-12-20 1998-06-25 Roehm Gmbh Adhesive and binder made from (meth) acrylate polymer, organic acid and plasticizer
DE19715794C1 (en) * 1997-04-16 1998-12-03 Roehm Gmbh Laminar dosage form and process for its preparation

Also Published As

Publication number Publication date
JP2004517157A (en) 2004-06-10
WO2002060417A1 (en) 2002-08-08
US20050019381A1 (en) 2005-01-27
DE20180358U1 (en) 2003-01-30

Similar Documents

Publication Publication Date Title
WO2002060417A8 (en) Binding agent which is stable in storage and used for pharmaceutical applications
BR0105102A (en) Multilayer medication for colon release
AU2003266351A1 (en) Multilayer dosage forms, which contain active substances and which comprise a neutral core, and an inner and outer coating consisting of methacrylate copolymers and methacrylate monomers
TR200100196T2 (en) Coating and binding agents for oral or dermal drug forms
AU2002363885A1 (en) Adhesive and binding agent for dermal or transdermal treatment systems
WO2000019984A3 (en) Coated medicament forms with controlled active substance release
EP2153827A3 (en) Composition for the Transdermal Delivery of Fentanyl
US4784856A (en) Percutaneous pharmaceutical preparation
DE60028256D1 (en) PRESSURE-SENSITIVE ADHESIVES AND STARBLOCK POLYMERS AND ACRYLIC POLYMERS CONTAINING OBJECTS
DE50107641D1 (en) COATING AND BINDING AGENT FOR MEDICINAL FORMULATIONS WITH IMPROVED STORAGE STABILITY
WO2007006353A3 (en) Use of a partially neutralized, anionic (meth)acrylate copolymer as a coating for the production of a medicament releasing active substance at reduced ph values
UA41873C2 (en) Pressurized aerosol composition
UA94917C2 (en) Topical formulations
WO1999051212A3 (en) Device for the transdermal delivery of diclofenac
CA2409069A1 (en) Hydrogel composition for transdermal drug delivery
NZ514946A (en) Transdermal therapeutic system comprising neutralized pressure-sensitive acrylate adhesives
EP0615983A3 (en) Pressure-sensitive adhesives having improved adhesion to acid-rain resistant automotive parts
WO2006010394A3 (en) Medicament in a multilayer form
CA2361602A1 (en) Firm hold hair mousse
MXPA04003540A (en) Use of a copolymer to produce a galenic form containing a peptide or a protein as active agent.
CA2444788A1 (en) Intrinsically-viscous clear-lacquer slurry, method for production and use thereof
PL328043A1 (en) Thickening agent of the basis of polymers containing carboxyl end carboxyloamide drug
CA2717259A1 (en) Controlled release drug delivery systems and pharmaceutical compositions formed therewith

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): DE JP US

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2002 560610

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: C1

Designated state(s): DE JP US

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 32/2002 UNDER (81) REPLACE "DE" BY "DE (UTILITY MODEL)"

WWE Wipo information: entry into national phase

Ref document number: 10239187

Country of ref document: US