KR860001068A - Process for preparing asymmetric 1,4-dihydropyridine-3,5-dicarboxylic acid diester - Google Patents

Process for preparing asymmetric 1,4-dihydropyridine-3,5-dicarboxylic acid diester Download PDF

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Publication number
KR860001068A
KR860001068A KR1019850005020A KR850005020A KR860001068A KR 860001068 A KR860001068 A KR 860001068A KR 1019850005020 A KR1019850005020 A KR 1019850005020A KR 850005020 A KR850005020 A KR 850005020A KR 860001068 A KR860001068 A KR 860001068A
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KR
South Korea
Prior art keywords
dihydropyridine
molecular sieve
dicarboxylic acid
activator
formula
Prior art date
Application number
KR1019850005020A
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Korean (ko)
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KR930011485B1 (en
Inventor
요시모또(외 4) 나까시마
Original Assignee
가미하라 쇼오지
다이쇼 세이야꾸 가부시끼가이샤
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Publication date
Priority claimed from JP14559984A external-priority patent/JPS6124568A/en
Priority claimed from JP14559784A external-priority patent/JPS6124566A/en
Priority claimed from JP14559884A external-priority patent/JPS6124567A/en
Application filed by 가미하라 쇼오지, 다이쇼 세이야꾸 가부시끼가이샤 filed Critical 가미하라 쇼오지
Publication of KR860001068A publication Critical patent/KR860001068A/en
Application granted granted Critical
Publication of KR930011485B1 publication Critical patent/KR930011485B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Catalysts (AREA)

Abstract

내용 없음No content

Description

비대칭 1,4-디히드로피리딘-3,5-디카르복실산 디에스테르의 제조방법Process for preparing asymmetric 1,4-dihydropyridine-3,5-dicarboxylic acid diester

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

하기 일반식(Ⅱ)의 1,4-디히드로피리딘-3,5-디카르복실산 모노에스테르를 카르복실산의 활성화제와 반응시키고, 생성된 일반식(Ⅱ)의 화합물의 반응 유도체를 하기 일반식(Ⅲ)의 알콜과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 비대칭 1,4-디히드로피리딘-3,5-디카르복실산 디에스테르의 제조방법.The 1,4-dihydropyridine-3,5-dicarboxylic acid monoester of the general formula (II) is reacted with an activator of carboxylic acid, and the reaction derivative of the compound of the general formula (II) A process for preparing an asymmetric 1,4-dihydropyridine-3,5-dicarboxylic acid diester of formula (I), characterized by reacting with an alcohol of formula (III). (상기 식중, R1및 R2는 서로 다르며, 2 또는 3탄소원자를 갖는 니트레이토알킬기를 각각 나타낸다.)(Wherein R 1 and R 2 are different from each other and represent nitrotoalkyl groups each having 2 or 3 carbon atoms.) 제1항에 있어서, 카르복실산의 활성화제가 무기염기, 무기염기와 무기염의 혼합물, 유기염기, 분자시이브 3A, 분자시이브 4A, 분자시이브 5A, 분자시이브 13X, 무수황산나트륨 또는 무수황산마그네슘과 같은 촉매 존재하의 유기산무수물인 방법.The activator of carboxylic acid according to claim 1, wherein the activator of carboxylic acid is inorganic base, mixture of inorganic base and inorganic salt, organic base, molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, molecular sieve 13X, sodium sulfate anhydrous or sulfuric anhydride Method of organic acid anhydride in the presence of a catalyst such as magnesium. 제2항에 있어서, 활성화제가 분자시이브 3A, 수산화나트륨 또는 수산화나트륨과 염화칼슘의 혼합물 존재하의 아세트산 무수물인 방법.The method of claim 2, wherein the activator is molecular sieve 3A, sodium hydroxide or acetic anhydride in the presence of a mixture of sodium hydroxide and calcium chloride. 제1항에 있어서, 일반식(Ⅰ)의 화합물이 2,6-디메틸-4-(3-니트로페닐)-1,4-디히드로피리딘-3,5-디카르복실산 3-(2-니트레이트프로필)에스테르 5-(3-니트레이토프로필)에스테르인 방법.The compound of formula (I) according to claim 1, wherein the compound of general formula (I) is 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid 3- (2- Nitrate propyl) ester 5- (3-nitreitopropyl) ester. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850005020A 1984-07-13 1985-07-13 Method for preparing unsymmetrical 1,4-dihydropyridine-3,5-dicarboxylic acid diesters KR930011485B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP59-145597 1984-07-13
JP84-145598 1984-07-13
JP14559984A JPS6124568A (en) 1984-07-13 1984-07-13 Preparation of dihydropyridine ester
JP14559784A JPS6124566A (en) 1984-07-13 1984-07-13 1,4-dihydropyridine derivative
JP84-145597 1984-07-13
JP14559884A JPS6124567A (en) 1984-07-13 1984-07-13 Dihydropyridine derivative
JP84-145599 1984-07-13

Publications (2)

Publication Number Publication Date
KR860001068A true KR860001068A (en) 1986-02-22
KR930011485B1 KR930011485B1 (en) 1993-12-08

Family

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Application Number Title Priority Date Filing Date
KR1019850005020A KR930011485B1 (en) 1984-07-13 1985-07-13 Method for preparing unsymmetrical 1,4-dihydropyridine-3,5-dicarboxylic acid diesters

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Country Link
US (1) US4730052A (en)
EP (1) EP0168789B1 (en)
KR (1) KR930011485B1 (en)
DE (1) DE3574868D1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6396126A (en) * 1986-10-13 1988-04-27 Taisho Pharmaceut Co Ltd Stabilized composition
JPS63295560A (en) * 1987-05-27 1988-12-01 Taisho Pharmaceut Co Ltd Optically active 1,4-dihydropyridine compound
US5958462A (en) * 1997-05-23 1999-09-28 Mclean; Linsey Therapeutic bath salts and method of use
US6962999B2 (en) * 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
DE60234057D1 (en) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc COMPOSITIONS AND METHODS FOR MODULATING TRANSPORT BY THE BLOOD-BRAIN BARRIER
CN103259027A (en) 2005-04-28 2013-08-21 普罗透斯数字保健公司 Pharma-informatics system
KR20090071598A (en) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 Treatment of liver disorders by administration of receptor-associated protein(rap)-conjugates
PT2398500T (en) 2009-02-20 2019-06-14 2 Bbb Medicines B V Glutathione-based drug delivery system
TWI556839B (en) 2009-05-06 2016-11-11 研究室護膚股份有限公司 Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996234A (en) * 1972-04-18 1976-12-07 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
US4483985A (en) * 1978-10-31 1984-11-20 Bayer Aktiengesellschaft Production of 1,4-dihydropyridinecarboxylic acids
JPS58185562A (en) * 1982-04-22 1983-10-29 Taisho Pharmaceut Co Ltd 1,4-dihydropyridine derivative

Also Published As

Publication number Publication date
EP0168789B1 (en) 1989-12-20
DE3574868D1 (en) 1990-01-25
EP0168789A3 (en) 1987-07-29
KR930011485B1 (en) 1993-12-08
US4730052A (en) 1988-03-08
EP0168789A2 (en) 1986-01-22

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