KR850008619A - 니페디핀 조성물의 제조방법 - Google Patents
니페디핀 조성물의 제조방법 Download PDFInfo
- Publication number
- KR850008619A KR850008619A KR1019850003501A KR850003501A KR850008619A KR 850008619 A KR850008619 A KR 850008619A KR 1019850003501 A KR1019850003501 A KR 1019850003501A KR 850003501 A KR850003501 A KR 850003501A KR 850008619 A KR850008619 A KR 850008619A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- nifedipine
- beta
- agent
- dosage form
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 니페디핀 1중량부, β-차페제 0.5 내지 10중량부 및 필요에 따라서, 통상의 보조제 및 부형제를 함유하고, 생물학적 유효성을 증진시키는 고상조성물.
- 제1항에 있어서, 아세부톨룰, 아테놀룰, 나돌룰, 프로프라놀룰, 핀돌룰 및 티몰롤로 되는 군 중에서 선택된 β-차페제를 하는 함유하는 혼합제.
- 제1항내지 제2항에 있어서, β-차페제로서 아세부톨을 함유하는 혼합제
- 제1항내지 제2항에 있어서, β-차페제로서 아테놀롤을 함유하는 혼합제
- 제1항내지 제4항에 있어서,니페디핀 1중량부와 β-차페제 1내지 5중량부를 함유하는 혼합제.
- 제1항내지 제5항에 있어서, 과립제, 정제, 래커를 입힌 정제 또는 코우팅된 정제형태의 혼합제.
- 니페디핀 1중량부와β-차페제 0.5내지10주량부를 보조제 및 부형제와 함께 조리화시키고, 필요에 따라서, 이 과립을 추가로 처리해서 통상의 투여형태로 제제함을 특징으로 하는 제1항의 혼합제의 제조방법.
- 제6항에있어서,니페디핀1중량부와β-차페제 1내지 5중량부를 전분, 셀룰로오즈, 필요에 따라서 기타 통상의 보조제와 함께 조립기중에서 습식조리화시키고, 생성된 과립을 통상의 투여형태로 전환시킴을 특징으로 하는 방법.
- 하기 일반식(∏)의 일린덴화합물을 용매로서 저급알코올(탄소원자수 1내지 4개), 적합하기로는 이 소프로판을 존재하에 0°~40℃ 사이의 온도에서, 일반식(Ⅲ)의 엔아민 화합물과 반응시키고, 생성된 니페디핀을 제7항에 의하여, 적합한 투여형태로 전환시킴을 특징으로 하는 제1항의 혼합제의 제조방법.
- 순환기관 길병을 치료하기 위한 제1항의 혼합제의 용도.※참고사항: 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843419130 DE3419130A1 (de) | 1984-05-23 | 1984-05-23 | Nifedipinkombinationspraeparate und verfahren zu ihrer herstellung |
DEP3419130.5 | 1984-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR850008619A true KR850008619A (ko) | 1985-12-21 |
Family
ID=6236598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850003501A KR850008619A (ko) | 1984-05-23 | 1985-05-22 | 니페디핀 조성물의 제조방법 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0165450A3 (ko) |
JP (1) | JPS60255724A (ko) |
KR (1) | KR850008619A (ko) |
CN (1) | CN85101820A (ko) |
AU (1) | AU4280785A (ko) |
DD (1) | DD237114A5 (ko) |
DE (1) | DE3419130A1 (ko) |
DK (1) | DK228085A (ko) |
ES (1) | ES8607725A1 (ko) |
GR (1) | GR851218B (ko) |
HU (1) | HUT38252A (ko) |
IL (1) | IL75244A0 (ko) |
PT (1) | PT80500B (ko) |
ZA (1) | ZA853878B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3427402A1 (de) * | 1984-07-25 | 1986-01-30 | Bayer Ag, 5090 Leverkusen | Neues kombinationspraeparat, verfahren zu seiner herstellung und seine verwendung als arzneimittel |
FR2577802B1 (fr) * | 1985-02-26 | 1987-07-24 | Synthelabo | Compositions pharmaceutiques a base de betaxolol et de nifedipine |
DE3610037A1 (de) * | 1986-03-21 | 1987-09-24 | Schering Ag | Nifedipinkombinationspraeparat |
DE3829398A1 (de) * | 1988-08-30 | 1990-03-08 | Rentschler Arzneimittel | Fixe arzneimittelkombination mit verzoegerter freisetzung |
AU2297192A (en) * | 1991-06-28 | 1993-01-25 | Sepracor, Inc. | Optically pure s(-) nadolol for treatment of cardiovascular disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
SU432703A3 (ko) * | 1971-08-24 | 1974-06-15 | Фридрих Боссерт, Вульф Фатер, Курт Бауер | |
DE2400819C2 (de) * | 1974-01-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung |
GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
EP0001247A1 (en) * | 1977-09-14 | 1979-04-04 | Kanebo, Ltd. | Pharmaceutical preparation containing nifedipine and a method for producing the same. |
-
1984
- 1984-05-23 DE DE19843419130 patent/DE3419130A1/de not_active Ceased
-
1985
- 1985-04-01 CN CN198585101820A patent/CN85101820A/zh active Pending
- 1985-05-11 EP EP85105796A patent/EP0165450A3/de not_active Withdrawn
- 1985-05-20 JP JP60106213A patent/JPS60255724A/ja active Pending
- 1985-05-20 GR GR851218A patent/GR851218B/el unknown
- 1985-05-20 IL IL75244A patent/IL75244A0/xx unknown
- 1985-05-21 DD DD85276559A patent/DD237114A5/de unknown
- 1985-05-21 PT PT80500A patent/PT80500B/pt unknown
- 1985-05-22 ZA ZA853878A patent/ZA853878B/xx unknown
- 1985-05-22 DK DK228085A patent/DK228085A/da not_active Application Discontinuation
- 1985-05-22 ES ES543389A patent/ES8607725A1/es not_active Expired
- 1985-05-22 KR KR1019850003501A patent/KR850008619A/ko not_active IP Right Cessation
- 1985-05-23 AU AU42807/85A patent/AU4280785A/en not_active Abandoned
- 1985-05-23 HU HU851960A patent/HUT38252A/hu unknown
Also Published As
Publication number | Publication date |
---|---|
HUT38252A (en) | 1986-05-28 |
ES543389A0 (es) | 1986-06-01 |
IL75244A0 (en) | 1985-09-29 |
GR851218B (ko) | 1985-11-25 |
JPS60255724A (ja) | 1985-12-17 |
EP0165450A3 (de) | 1986-03-12 |
EP0165450A2 (de) | 1985-12-27 |
CN85101820A (zh) | 1987-01-10 |
ZA853878B (en) | 1986-01-29 |
DD237114A5 (de) | 1986-07-02 |
AU4280785A (en) | 1985-11-28 |
PT80500A (en) | 1985-06-01 |
DK228085A (da) | 1985-11-24 |
ES8607725A1 (es) | 1986-06-01 |
DE3419130A1 (de) | 1985-11-28 |
PT80500B (en) | 1987-04-21 |
DK228085D0 (da) | 1985-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SUBM | Surrender of laid-open application requested |