KR850004961A - Method for preparing salicylic acid derivative having anti-inflammatory analgesic effect - Google Patents

Method for preparing salicylic acid derivative having anti-inflammatory analgesic effect Download PDF

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Publication number
KR850004961A
KR850004961A KR1019830006297A KR830006297A KR850004961A KR 850004961 A KR850004961 A KR 850004961A KR 1019830006297 A KR1019830006297 A KR 1019830006297A KR 830006297 A KR830006297 A KR 830006297A KR 850004961 A KR850004961 A KR 850004961A
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KR
South Korea
Prior art keywords
hydrogen
salicylic acid
chlorine
acid derivative
bromine
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Application number
KR1019830006297A
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Korean (ko)
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KR860000587B1 (en
Inventor
2) 옥광대(외
Original Assignee
손정삼
동아제약 주식회사
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Priority to KR1019830006297A priority Critical patent/KR860000587B1/en
Publication of KR850004961A publication Critical patent/KR850004961A/en
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Publication of KR860000587B1 publication Critical patent/KR860000587B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

소염진통작용을 갖는 실리실산 유도체의 제조방법Method for preparing silicic acid derivative having anti-inflammatory analgesic effect

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

다음 구조식(Ⅱ)의 살리실산 유도체에 다음 구조식Ⅲ)의 디치환 톨루인산이나 그 염을 반응시켜 다음 구조식(Ⅰ)의 프탈리딜 살리실산 에스테르를 제조하는 방법.A method of preparing phthalidyl salicylic acid ester of the following formula (I) by reacting salicylic acid derivative of the following formula (II) with di-substituted toluic acid or its salt of formula III). 상기식에서 A는 수소, 불소, 염소, 브롬 또는 요오드 중에서 선택될 수 있으며, B는 하이드록시, 아세톡시 또는 다음의 일반식으로 표시되는 아닐린기이다.Wherein A may be selected from hydrogen, fluorine, chlorine, bromine or iodine, and B is hydroxy, acetoxy or an aniline group represented by the following general formula. R1및 R2는 각각 수소, 염소, 불소, 메칠 또는 트리플루오로 메칠이다. R 및 R3는 각각 수소 또는 칼륨, 나트륨의 알칼리금속이며 X는 불소, 브롬, 염소, 요오드이거나 아릴설포닐 옥시 또는 알킬설포닐 옥시기이다.R 1 and R 2 are each hydrogen, chlorine, fluorine, methyl or trifluoro methyl. R and R 3 are each hydrogen or an alkali metal of potassium, sodium and X is fluorine, bromine, chlorine, iodine or arylsulfonyl oxy or alkylsulfonyl oxy group. A가 수소인 경우의 특허청구 범위 제1항의 제조방법.The method according to claim 1, wherein A is hydrogen. B가 아세톡시기인 경우의 특허청구범위 제1항 또는 제2항의 제조방법.The manufacturing method of Claim 1 or 2 when B is an acetoxy group. B에서 R1과 R2중 하나는 수소이고, 다른 하나는 트리플루오로 메칠인 경우의 특허청구 범위 제1항 또는 제2항의 제조방법.The process according to claim 1, wherein one of R 1 and R 2 in B is hydrogen and the other is trifluoromethyl. B에서 R1및 R2가 각각 메칠로 치환된 아닐린인 경우의 특허청구 범위 제1항 또는 제2항의 제조방법.The process according to claim 1 or 2 , wherein in R, R 1 and R 2 are each aniline substituted with methyl. B에서 R1이 메칠, R2가 염소인 경우의 특허청구 범위 제1항 또는 제2항의 제조방법.R 1 in B is methylene, the claims in the case R 2 is chlorine claim 1 or claim 2 method. X가 브롬인 경우의 특허청구 범위 제1항, 제2항, 제3항, 제4항, 제5항 또는 제6항의 제조방법.The method of claim 1, 2, 3, 4, 5 or 6 when X is bromine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830006297A 1983-12-30 1983-12-30 Process for preparing analgesic anti-inflammatory salicy acid derivatives KR860000587B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019830006297A KR860000587B1 (en) 1983-12-30 1983-12-30 Process for preparing analgesic anti-inflammatory salicy acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019830006297A KR860000587B1 (en) 1983-12-30 1983-12-30 Process for preparing analgesic anti-inflammatory salicy acid derivatives

Publications (2)

Publication Number Publication Date
KR850004961A true KR850004961A (en) 1985-08-19
KR860000587B1 KR860000587B1 (en) 1986-05-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006297A KR860000587B1 (en) 1983-12-30 1983-12-30 Process for preparing analgesic anti-inflammatory salicy acid derivatives

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KR (1) KR860000587B1 (en)

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KR860000587B1 (en) 1986-05-17

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