KR850002952A - 불안정한 활성성분을 함유한 젤상 외용제의 제조방법 - Google Patents
불안정한 활성성분을 함유한 젤상 외용제의 제조방법 Download PDFInfo
- Publication number
- KR850002952A KR850002952A KR1019830004828A KR830004828A KR850002952A KR 850002952 A KR850002952 A KR 850002952A KR 1019830004828 A KR1019830004828 A KR 1019830004828A KR 830004828 A KR830004828 A KR 830004828A KR 850002952 A KR850002952 A KR 850002952A
- Authority
- KR
- South Korea
- Prior art keywords
- active ingredient
- glycol
- fatty acid
- preparation
- acid
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- -1 glycerin fatty acid ester Chemical class 0.000 claims 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 229940117916 cinnamic aldehyde Drugs 0.000 claims 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229960002433 cysteine Drugs 0.000 claims 1
- 150000005690 diesters Chemical class 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 229940051250 hexylene glycol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229960005322 streptomycin Drugs 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 불안정한 활성성분을 다가알콜 단독 또는 그 혼합물에 45-75℃에서 용해시킨 다음 비이온 계면활성제, 오일을 첨가한 후 가열 혼합한 후 실온으로 냉각하는 불안정한 활성성분을 함유한 젤상 외용제의 제조방법.
- 제1항에 있어서, 불안정한 활성성분으로서 아스코르빈산 및 아스코르빈산과 지방족 알콜의 모노 또는 디에스테르, 하이드로퀴논, 카테콜, 티오우레아, 티오글리콜산, 시스테인, 글루타치온, 황산스트렙토마이신, 겐타마이신, 신나믹알데하이드, D-구루콘산, D-δ-구루코놀락톤, D-δ-구루쿠로노락톤, D-구로쿠로닌산으로 구성된 군중에서 선택하는 방법.
- 제1항에 있어서, 다가알콜로서 솔비톨, 폴리프로필렌글리콜, 만니톨, 프로필렌글리콜, 글리세린, 1.3-부틸렌글리콜, 헥실렌글리콜, 폴리에틸렌글리콜로 구성된 군중에서 선택하는 방법.
- 제1항에 있어서, 비이온성 계면활성제로서 글리세린지방산에스테르, 소르비탄지방산에스테르, 폴리옥시에틸렌소르비탄지방산에스테르로 구성된 군중에서 선택하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019830004828A KR850001494B1 (ko) | 1983-10-12 | 1983-10-12 | 불안정한 활성 성분을 함유한 젤상 피부보호 및 미용제의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019830004828A KR850001494B1 (ko) | 1983-10-12 | 1983-10-12 | 불안정한 활성 성분을 함유한 젤상 피부보호 및 미용제의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR850002952A true KR850002952A (ko) | 1985-05-28 |
| KR850001494B1 KR850001494B1 (ko) | 1985-10-11 |
Family
ID=19230149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830004828A KR850001494B1 (ko) | 1983-10-12 | 1983-10-12 | 불안정한 활성 성분을 함유한 젤상 피부보호 및 미용제의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR850001494B1 (ko) |
-
1983
- 1983-10-12 KR KR1019830004828A patent/KR850001494B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR850001494B1 (ko) | 1985-10-11 |
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| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
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| FPAY | Annual fee payment |
Payment date: 19880213 Year of fee payment: 11 |
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| LAPS | Lapse due to unpaid annual fee |