KR850001197A - Method for preparing xanthine derivative - Google Patents

Method for preparing xanthine derivative Download PDF

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Publication number
KR850001197A
KR850001197A KR1019840003861A KR840003861A KR850001197A KR 850001197 A KR850001197 A KR 850001197A KR 1019840003861 A KR1019840003861 A KR 1019840003861A KR 840003861 A KR840003861 A KR 840003861A KR 850001197 A KR850001197 A KR 850001197A
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KR
South Korea
Prior art keywords
compound
formula
carried out
process according
xanthine derivative
Prior art date
Application number
KR1019840003861A
Other languages
Korean (ko)
Inventor
배가 노베롤라(외 3) 아르만도
Original Assignee
원본미기재
포르도날 에스 에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 원본미기재, 포르도날 에스 에이 filed Critical 원본미기재
Publication of KR850001197A publication Critical patent/KR850001197A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음No content

Description

크산틴 유도체의 제조방법Method for preparing xanthine derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (8)

구조식(II)를 갖는 화합물을 구조식(III)을 갖는 화합물의 반응성 유도체와 반응시키는 것으로 구성된 구조식(I)을 갖는 화합물을 제조하는 방법.A process for preparing a compound having formula (I) consisting of reacting a compound having formula (II) with a reactive derivative of a compound having formula (III). 제1항에 있어서, 반응성 유도체가 카르복실산의 염화물브롬, 화물이미다졸린일 아미드 또는 무수물인 방법.The method of claim 1, wherein the reactive derivative is bromine chloride, carlimidazolinyl amide or anhydride of carboxylic acid. 제1항 또는 제3항에 있어서, 10-90℃에서 실시되는 방법.The process according to claim 1 or 3, which is carried out at 10-90 ° C. 제1항 내지 제3항중 어느 하나에 있어서, 불활성 용매의 존재하에 실시되는 방법.The process according to claim 1, wherein the process is carried out in the presence of an inert solvent. 제4항에 있어서, 용매가 아세톤, 디옥산, 메틸렌 클로라이드, 벤젠, 톨루엔 또는 피리딘인 방법.The process of claim 4 wherein the solvent is acetone, dioxane, methylene chloride, benzene, toluene or pyridine. 제1항 내지 제5항중 어느 하나에 있어서, 3급 아민의 존재하에 실시되는 방법.The process according to claim 1, wherein the process is carried out in the presence of a tertiary amine. 제6항에 있어서, 아민이 트리에틸아민인 방법.The method of claim 6, wherein the amine is triethylamine. 제1항의 화합물과 약제학적으로 사용 가능한 담체 또는 희석제를 회합하는 것으로 구성된 약제학적 조성물을 생산하는 방법.A method of producing a pharmaceutical composition consisting of associating a compound of claim 1 with a pharmaceutically usable carrier or diluent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840003861A 1983-07-05 1984-07-04 Method for preparing xanthine derivative KR850001197A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES523854 1983-07-05
ES523854A ES523854A0 (en) 1983-07-05 1983-07-05 PROCEDURE FOR THE PREPARATION OF A XANTHINIC DERIVATIVE.

Publications (1)

Publication Number Publication Date
KR850001197A true KR850001197A (en) 1985-03-16

Family

ID=8485967

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003861A KR850001197A (en) 1983-07-05 1984-07-04 Method for preparing xanthine derivative

Country Status (7)

Country Link
JP (1) JPS6084290A (en)
KR (1) KR850001197A (en)
DE (1) DE3424620A1 (en)
ES (1) ES523854A0 (en)
FR (1) FR2554449A1 (en)
GB (1) GB2143233A (en)
IT (1) IT1180197B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2097015A1 (en) * 1970-07-27 1972-03-03 Investigations Sci Pharm Esters of 7-(2,3-dihydroxypropyl)theophylline - cardiovascular and respiratory system active
DE3037391A1 (en) * 1980-10-03 1982-05-19 King Consult GmbH, 5000 Köln ESTERS OF 7-HYDROXYALKYL-1,3-DIMETHYLXANTHINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A LIPID-REDUCING AGENT

Also Published As

Publication number Publication date
FR2554449A1 (en) 1985-05-10
JPS6084290A (en) 1985-05-13
DE3424620A1 (en) 1985-01-17
GB2143233A (en) 1985-02-06
IT8421743A0 (en) 1984-07-04
IT1180197B (en) 1987-09-23
IT8421743A1 (en) 1986-01-04
GB8417008D0 (en) 1984-08-08
ES8502113A1 (en) 1984-12-16
ES523854A0 (en) 1984-12-16

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