KR850000453A - Method for preparing cephalosporin acid and its derivatives - Google Patents

Method for preparing cephalosporin acid and its derivatives Download PDF

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Publication number
KR850000453A
KR850000453A KR1019830002830A KR830002830A KR850000453A KR 850000453 A KR850000453 A KR 850000453A KR 1019830002830 A KR1019830002830 A KR 1019830002830A KR 830002830 A KR830002830 A KR 830002830A KR 850000453 A KR850000453 A KR 850000453A
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KR
South Korea
Prior art keywords
group
structural formula
methyl
hydroxy
hydrogen
Prior art date
Application number
KR1019830002830A
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Korean (ko)
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KR860000451B1 (en
Inventor
김승호
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김승호
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Publication date
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Priority to KR1019830002830A priority Critical patent/KR860000451B1/en
Publication of KR850000453A publication Critical patent/KR850000453A/en
Application granted granted Critical
Publication of KR860000451B1 publication Critical patent/KR860000451B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음.No content.

Description

세팔로스포린산과 그 유도체의 제조방법Method for preparing cephalosporin acid and its derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

본문에 상술한 바와 같이 다음 구조식(V)와 다음 구조식(VI)을 폴리포스페이트 중에서 반응시켜 다음 구조식(IV)를 제조하고 다음 구조식(IV)와 다음 구조식(IIa) 혹은 (IIb)와 반응하여 다음 구조식(I)과 같은 화합물을 제조하는 방법.As described above, the following structural formula (V) and the following structural formula (VI) are reacted in polyphosphate to prepare the following structural formula (IV), and the next structural formula (IV) and the next structural formula (IIa) or (IIb) A process for preparing a compound such as formula (I). 상기 구조식에서, R1은 2-포밀옥시-2-페닐 메틸기 혹은 2-하이드록시-2-페닐메틸기 혹은 2-아미노-(4-하이드록시페닐) 메틸기 혹은 (4-에틸-2,3-디옥소-1-피페라진카복사미도)-4-하이드록시페닐메틸기 혹은 카복시-4-하이드록시페닐메틸기 혹은 2-아미노티아졸-4-일-메톡시아미노메틸기 혹은 4-하이드록시-6-메틸피리딘-카복사미도-(4-하이드록시페닐)메틸기 혹은 아미노카복시-에틸티오 메틸기 혹은 트리훌루오로 메틸티오메틸기 혹은 시아노비닐렌 티오메틸기 등이며, R2는 수소 혹은 메톡시기이며, R3는 1-메틸-1H-테트라졸-5-일기 혹은 1,2,3-트리아졸-5일기 혹은 1-카복시메틸-테트라졸-5일기 혹은 1,3,4-티아디아졸-5-일기 혹은 벤지미다졸-2-일기이며, R4는 수소 혹은 보호기 혹은, 나트륨, 포타슘이며, Z는 황 혹은 산소이며, A는 다음과 같은 식으로 표시된다.In the above structural formula, R 1 is a 2-formyloxy-2-phenyl methyl group or 2-hydroxy-2-phenylmethyl group or 2-amino- (4-hydroxyphenyl) methyl group or (4-ethyl-2,3-di Oxo-1-piperazinecarboxamido) -4-hydroxyphenylmethyl group or carboxy-4-hydroxyphenylmethyl group or 2-aminothiazol-4-yl-methoxyaminomethyl group or 4-hydroxy-6-methyl A pyridine-carboxamido- (4-hydroxyphenyl) methyl group or an aminocarboxy-ethylthio methyl group or a trifluoro methylthiomethyl group or a cyanovinylene thiomethyl group, and R 2 is hydrogen or a methoxy group, and R 3 Is a 1-methyl-1H-tetrazol-5-yl group or 1,2,3-triazol-5yl group or 1-carboxymethyl-tetrazol-5yl group or 1,3,4-thiadiazol-5-yl group Or a benzimidazol-2-yl group, R 4 is hydrogen or a protecting group or sodium, potassium, Z is sulfur or oxygen, and A is represented by the following formula. 상기 구조식에서, n은 0에서 3까지 이며, R5는 수소 혹은 하이드록시 기이다.Wherein n is from 0 to 3 and R 5 is hydrogen or a hydroxy group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830002830A 1983-06-23 1983-06-23 Process for preparing cephalosporin derivatives KR860000451B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019830002830A KR860000451B1 (en) 1983-06-23 1983-06-23 Process for preparing cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019830002830A KR860000451B1 (en) 1983-06-23 1983-06-23 Process for preparing cephalosporin derivatives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1019810002502A Division KR860000266B1 (en) 1980-07-10 1981-07-10 Soft steroids having anti-inflammatory activity

Publications (2)

Publication Number Publication Date
KR850000453A true KR850000453A (en) 1985-02-27
KR860000451B1 KR860000451B1 (en) 1986-04-26

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Application Number Title Priority Date Filing Date
KR1019830002830A KR860000451B1 (en) 1983-06-23 1983-06-23 Process for preparing cephalosporin derivatives

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KR (1) KR860000451B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100301610B1 (en) * 2000-09-29 2001-09-22 장인순 Method of treatment of industrial wastewater using SOx absorption waste solutionr

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100301610B1 (en) * 2000-09-29 2001-09-22 장인순 Method of treatment of industrial wastewater using SOx absorption waste solutionr

Also Published As

Publication number Publication date
KR860000451B1 (en) 1986-04-26

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