KR840009300A - Process for preparing piperazinone - Google Patents

Process for preparing piperazinone Download PDF

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Publication number
KR840009300A
KR840009300A KR1019840002495A KR840002495A KR840009300A KR 840009300 A KR840009300 A KR 840009300A KR 1019840002495 A KR1019840002495 A KR 1019840002495A KR 840002495 A KR840002495 A KR 840002495A KR 840009300 A KR840009300 A KR 840009300A
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KR
South Korea
Prior art keywords
formula
compound
hydrogen
radicals
chr
Prior art date
Application number
KR1019840002495A
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Korean (ko)
Inventor
솜브로크 조하네스
Original Assignee
감스, 나우만
메르크 페턴트 게젤샤프트 미트 베슈랭크터 하프퉁
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Application filed by 감스, 나우만, 메르크 페턴트 게젤샤프트 미트 베슈랭크터 하프퉁 filed Critical 감스, 나우만
Publication of KR840009300A publication Critical patent/KR840009300A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

피페라지논의 제조방법Process for preparing piperazinone

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

하기식(Ⅱ)의 화합물 또는 이것의 반응성유도체를 고리화하거나 하기식(Ⅲ)의 화합물을 환원시키거나 하기식(Ⅳ)의 화합물을 2-페닐에탄올 또는 이것의 반응유도체와 반응시키고, R1과R2두기가 함께 C-C결합인 하기식(Ⅰ)의 화합물을 제조하기 위해 R1및 R2라디칼중 어느 한 라디칼이 OH이고, 다른 하나가 수소인 하기식(Ⅰ)의 화합물을 탈수시키거나 하기식(Ⅰ)의 화합물에서 라디칼 R을 다른 라디칼 R로 전환시키거나 하기식(Ⅰ)의 염기성 또는 산성화합물을 대응하는 염으로 전환시키거나 염으로부터 유리시키는 단계로 구성되는 것을 특징으로 하는 하기식(Ⅰ)의 피페라지논을 제조하는 방법.Cyclizing the compound of formula (II) or a reactive derivative thereof or reducing the compound of formula (III) or reacting a compound of formula (IV) with 2-phenylethanol or a reaction derivative thereof, R 1 In order to prepare a compound of formula (I) wherein both R 2 groups are CC bonds together, dehydration of a compound of formula (I) wherein one of R 1 and R 2 radicals is OH and the other is hydrogen In a compound of formula (I): converting radical R to another radical R or converting a basic or acidic compound of formula (I) to a corresponding salt or liberating from a salt The method of manufacturing the piperazinone of (I). 상기식에서, R은 수소 또는 1-26개의 탄소원자를 갖는 아실기이며, R1및 R2라디칼 중 어는 하나는 OH이며 다른 하나는 수소이거나 혹은 R1및 R2두 라디칼이 함께 C-C결합을 형성하며, R3는 수소이고, R4는 -COCH2-NR-CH2-CHO이거나 R3는 -CH2CHO이고 R4는 -CO-CH2-NH-R 이거나 R3는 수소이고 R4는-CHR1-CHR2-NR-CH2-COOH이거나 R3는-CO-CH2OH이고 R4는 -CHR1-CHR2-NH-R이며, R5및 R6두 라디칼중 어느 하나는 산소원자이고 다른 하나는 두개의 수소원자임.Wherein R is hydrogen or an acyl group having 1-26 carbon atoms, one of the R 1 and R 2 radicals is OH and the other is hydrogen, or both R 1 and R 2 radicals together form a CC bond R 3 is hydrogen, R 4 is -COCH 2 -NR-CH 2 -CHO or R 3 is -CH 2 CHO and R 4 is -CO-CH 2 -NH-R or R 3 is hydrogen and R 4 is -CHR 1 -CHR 2 -NR-CH 2 -COOH or R 3 is -CO-CH 2 OH and R 4 is -CHR 1 -CHR 2- NH-R, either of R 5 and R 6 Oxygen atom and the other two hydrogen atoms. 상기식(Ⅰ)의 화합물을 고리화하고 하기식(Ⅴ)의 화합물에서 라디칼 R을 다른 라디칼 R로 전환시키거나 하기식(Ⅴ)의 염기성 혹은 산 화합물을 대응하는 염으로 전환시키거나 대응하는 염으로부터 유리시키는 것을 특징으로 하는 하기식(Ⅴ)의 화합물 및 이의염의 제조방법.The compounds of formula (I) are cyclized and the radicals R are converted to other radicals R in the compounds of formula (V) or the basic or acid compounds of formula (V) are converted to the corresponding salts or the corresponding salts. Method for producing a compound of the formula (V) and salts thereof, characterized in that liberated from. 상기식에서 R은 수소 또는 1-26개의 탄소원자를 가진 아실기임.Wherein R is hydrogen or an acyl group having 1-26 carbon atoms. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840002495A 1983-05-09 1984-05-09 Process for preparing piperazinone KR840009300A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3316928A DE3316928A1 (en) 1983-05-09 1983-05-09 Piperazinones
DEP3316928.4 1983-05-09

Publications (1)

Publication Number Publication Date
KR840009300A true KR840009300A (en) 1984-12-26

Family

ID=6198561

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002495A KR840009300A (en) 1983-05-09 1984-05-09 Process for preparing piperazinone

Country Status (4)

Country Link
JP (1) JPS59206365A (en)
KR (1) KR840009300A (en)
DE (1) DE3316928A1 (en)
EG (1) EG16998A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103910725B (en) * 2013-01-09 2015-12-02 江南大学 One class Praziquantel Analogues, Preparation Method And The Use
CN105061424B (en) * 2015-08-31 2016-10-05 上海海洋大学 A kind of synthetic method of praziquantel metabolite
CN112645888A (en) * 2020-12-24 2021-04-13 厦门优孚利生物医药科技有限公司 One-pot synthesis method of praziquantel intermediate

Also Published As

Publication number Publication date
JPS59206365A (en) 1984-11-22
EG16998A (en) 1990-08-30
DE3316928A1 (en) 1984-11-15

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