KR840008283A - Method for preparing biponazole composition - Google Patents

Method for preparing biponazole composition Download PDF

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Publication number
KR840008283A
KR840008283A KR1019840001658A KR840001658A KR840008283A KR 840008283 A KR840008283 A KR 840008283A KR 1019840001658 A KR1019840001658 A KR 1019840001658A KR 840001658 A KR840001658 A KR 840001658A KR 840008283 A KR840008283 A KR 840008283A
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KR
South Korea
Prior art keywords
composition
biponazole
diluent
imidazole
suitably
Prior art date
Application number
KR1019840001658A
Other languages
Korean (ko)
Inventor
아담스 카를하인츠
Original Assignee
요아힘 그렘, 귄터 페터스
바이엘 아코티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 요아힘 그렘, 귄터 페터스, 바이엘 아코티엔 게젤샤프트 filed Critical 요아힘 그렘, 귄터 페터스
Publication of KR840008283A publication Critical patent/KR840008283A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음.No content.

Description

바이폰아졸 조성물의 제조방법Method for preparing biponazole composition

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

구조식(II)의 카빈올을 적절하게는 희석제의 존재하에서 티오닐-비스-이미다졸과 반응시키거나; 일반식(III)의 할로게노-메탄을 적절하게는 산결합제 및 희석제의 존재하에서 이미다졸과 반응시키거나, 적절하게는 희석제의 존재하에서 이미다졸의 은염 또는 알카리금속염과 반응시키거나, 적절하게는 희석제의 존재하에서 구조식(IV)의 트리메틸실릴 이미다졸과 반응시키고; 이렇게 하여 수득된 구조식(I)의 아졸-1-일 메탄을 경우에 따라 생리적으로 허용되는 산과 반응시킨 후, 그 생성물을 10 내지 60%의 확산제 및 20 내지 80%의 용매와 혼합하고 필요한 경우 분출제(propellant)와 혼합함을 특징으로 하여 바이폰아졸 조성물을 제조하는 방법.The carbinol of formula (II) is reacted with thionyl-bis-imidazole, suitably in the presence of a diluent; Halogeno-methane of formula (III) is suitably reacted with imidazole in the presence of an acid binder and a diluent, or suitably with a silver or alkali metal salt of imidazole in the presence of a diluent, or suitably Reacting with trimethylsilyl imidazole of formula IV in the presence of a diluent; The sozol-1-yl methane of structure (I) thus obtained is reacted with a physiologically acceptable acid, as the case may be, and then the product is mixed with 10 to 60% of a diffusing agent and 20 to 80% of a solvent and, if necessary, A process for producing a biponazole composition, characterized by mixing with a propellant. 상기 식에서, Hal은 할로겐이다.Wherein Hal is halogen. 제1항에 있어서, 0.05 내지 1.5%, 바람직하게는 1%의 바이폰아졸을 함유함을 특징으로 하는 조성물의 제조방법.Process according to claim 1, characterized in that it contains 0.05 to 1.5%, preferably 1% of biponazole. 제1항에 있어서, 애제임을 특징으로 하는 조성물의 제조방법.The method of claim 1, wherein the composition is an agent. 제1항에 있어서, 분무제임을 특징으로 하는 조성물의 제조방법.The method of claim 1 wherein the composition is a spray. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840001658A 1983-03-30 1984-03-30 Method for preparing biponazole composition KR840008283A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833311700 DE3311700A1 (en) 1983-03-30 1983-03-30 ANTIMYCOTIC AGENTS WITH HIGH ACTIVE SUBSTANCE RELEASE IN THE FORM OF SOLUTION AND SPRAY
DEP3311700.4 1983-03-30

Publications (1)

Publication Number Publication Date
KR840008283A true KR840008283A (en) 1984-12-14

Family

ID=6195161

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001658A KR840008283A (en) 1983-03-30 1984-03-30 Method for preparing biponazole composition

Country Status (18)

Country Link
JP (1) JPS59184125A (en)
KR (1) KR840008283A (en)
AU (1) AU564979B2 (en)
BE (1) BE899277A (en)
CA (1) CA1212328A (en)
CH (1) CH660304A5 (en)
DE (1) DE3311700A1 (en)
ES (3) ES8503946A1 (en)
FR (1) FR2543436B1 (en)
GB (1) GB2137090B (en)
GR (1) GR81880B (en)
IL (1) IL71363A0 (en)
IT (1) IT1173762B (en)
LU (1) LU85272A1 (en)
PH (1) PH20964A (en)
PT (1) PT78312B (en)
SE (1) SE8401747L (en)
ZA (1) ZA842336B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2555555B2 (en) * 1991-07-03 1996-11-20 武田薬品工業株式会社 Antifungal topical formulation
US5246716A (en) * 1992-01-10 1993-09-21 W. Neudorff Gmbh Kg Fatty acid-based antifungal composition having residual activity
WO1997021426A1 (en) * 1995-12-14 1997-06-19 Taisho Pharmaceutical Co., Ltd. Aerosol preparation
ES2589077T3 (en) * 2002-06-25 2016-11-10 Acrux Dds Pty Ltd Control of the transdermal administration rate using amorphous pharmaceutical compositions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461406C2 (en) * 1974-12-24 1984-06-14 Bayer Ag, 5090 Leverkusen Azolyl- (1) -methanes and their salts, processes for their preparation and medicaments containing them
JPS6018655B2 (en) * 1976-01-01 1985-05-11 バイエル・アクチエンゲゼルシヤフト Azolyl-(1)-methanes and their salts
JPS5598112A (en) * 1979-01-17 1980-07-25 Sumitomo Chem Co Ltd Liquid medicine for external use
DE3019027A1 (en) * 1980-05-19 1981-11-26 Bayer Ag, 5090 Leverkusen ANTIMICROBIAL AGENTS
DE3045914A1 (en) * 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen ANTIMYCOTIC AGENTS WITH HIGH ACTIVE SUBSTANCE RELEASE IN THE FORM OF ELASTIC LIQUID PLASTERS
DE3045915A1 (en) * 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen ANTIMYCOTIC AGENTS WITH HIGH ACTIVE SUBSTANCE RELEASE IN THE FORM OF ELASTIC LIQUID PLASTERS
DE3045913A1 (en) * 1980-12-05 1982-07-08 Bayer Ag, 5090 Leverkusen ANTIMYCOTIC AGENTS WITH HIGH ACTIVE SUBSTANCE RELEASE
DE3106635A1 (en) * 1981-02-23 1982-09-09 Bayer Ag ANTIMYCOTIC AGENT WITH HIGH ACTIVE SUBSTANCE RELEASE IN THE FORM OF PEN

Also Published As

Publication number Publication date
JPS59184125A (en) 1984-10-19
GB2137090B (en) 1986-07-09
AU564979B2 (en) 1987-09-03
GB2137090A (en) 1984-10-03
ES530845A0 (en) 1985-04-16
SE8401747D0 (en) 1984-03-29
GR81880B (en) 1984-12-12
CH660304A5 (en) 1987-04-15
IT8420304A0 (en) 1984-03-29
ES8503946A1 (en) 1985-04-16
IL71363A0 (en) 1984-06-29
BE899277A (en) 1984-10-01
SE8401747L (en) 1984-10-01
AU2623584A (en) 1984-10-04
ES539275A0 (en) 1985-11-16
ES8601690A1 (en) 1985-11-16
ES8601691A1 (en) 1985-11-16
FR2543436A1 (en) 1984-10-05
DE3311700A1 (en) 1984-10-04
ES539274A0 (en) 1985-11-16
FR2543436B1 (en) 1988-12-16
ZA842336B (en) 1984-11-28
LU85272A1 (en) 1984-11-14
PT78312A (en) 1984-04-01
PT78312B (en) 1986-06-02
PH20964A (en) 1987-06-10
GB8408066D0 (en) 1984-05-10
CA1212328A (en) 1986-10-07
IT1173762B (en) 1987-06-24

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