KR840005730A - Method for preparing a compound having analgesic and anti-inflammatory action - Google Patents

Method for preparing a compound having analgesic and anti-inflammatory action Download PDF

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Publication number
KR840005730A
KR840005730A KR1019830003644A KR830003644A KR840005730A KR 840005730 A KR840005730 A KR 840005730A KR 1019830003644 A KR1019830003644 A KR 1019830003644A KR 830003644 A KR830003644 A KR 830003644A KR 840005730 A KR840005730 A KR 840005730A
Authority
KR
South Korea
Prior art keywords
chlorobenzoyl
dimethyl
analgesic
preparing
compound
Prior art date
Application number
KR1019830003644A
Other languages
Korean (ko)
Inventor
모마사롤리 기안기아코
Original Assignee
원본미기재
폴리 인더스트리아 키미카 에스·피·에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 폴리 인더스트리아 키미카 에스·피·에이 filed Critical 원본미기재
Publication of KR840005730A publication Critical patent/KR840005730A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

진통 및 소염작용을 갖는 화합물의 제조방법Method for preparing a compound having analgesic and anti-inflammatory action

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

1,4-디메틸-5-(4-클로로벤조일)-2-피롤초산의 에스테르를 과량몰의 2-아미노피리딘과 70-200℃의 온도범위에서 반응시켜 하기 일반식(Ⅰ)의 N-(2-피리딜)-〔1,4-디메틸-5-(4-클로로벤조일)〕-2-피롤아세타미드를 제조하는 방법.An ester of 1,4-dimethyl-5- (4-chlorobenzoyl) -2-pyrrole acetic acid is reacted with an excess molar 2-aminopyridine at a temperature in the range of 70-200 ° C. to give N- ( 2-Pyridyl)-[1,4-dimethyl-5- (4-chlorobenzoyl)]-2-pyrroleacetamide. 제1항에 있어서, 사용되는 에스테르가 시아노메틸 에스테르인 제조방법.The process according to claim 1, wherein the ester used is cyanomethyl ester. 활성성분 N-(2-피리딜)-〔1,4-디메틸-5-(4-클로로벤조일)〕-2-피롤아세타미드 및 약리적으로 알맞은 부형제 또는 담체가 포함된 제약조성물.A pharmaceutical composition comprising the active ingredient N- (2-pyridyl)-[1,4-dimethyl-5- (4-chlorobenzoyl)]-2-pyrroleacetamide and a pharmacologically suitable excipient or carrier. 제3항에 있어서, 정제, 당의정, 캅셀제, 시럽제, 점적제, 좌제 및 미크로클리즘(microclisms)의 제형으로 되어 있는 제약조성물.4. A pharmaceutical composition according to claim 3 in the form of tablets, dragees, capsules, syrups, drops, suppositories, and microclisms. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830003644A 1982-08-04 1983-08-04 Method for preparing a compound having analgesic and anti-inflammatory action KR840005730A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22730A/82 1982-08-04
IT22730/82A IT1190942B (en) 1982-08-04 1982-08-04 COMPOUND WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY, ITS PREPARATION PROCEDURE AND RELATED PHARMACEUTICAL COMPOSITIONS

Publications (1)

Publication Number Publication Date
KR840005730A true KR840005730A (en) 1984-11-16

Family

ID=11199756

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003644A KR840005730A (en) 1982-08-04 1983-08-04 Method for preparing a compound having analgesic and anti-inflammatory action

Country Status (9)

Country Link
JP (1) JPS5962586A (en)
KR (1) KR840005730A (en)
BE (1) BE897365A (en)
DE (1) DE3327080A1 (en)
ES (1) ES8502436A1 (en)
FR (1) FR2531954A1 (en)
GB (1) GB2127014B (en)
IT (1) IT1190942B (en)
PT (1) PT77025B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA848275B (en) * 1983-12-28 1985-08-28 Degussa New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors

Also Published As

Publication number Publication date
FR2531954A1 (en) 1984-02-24
IT1190942B (en) 1988-02-24
JPS5962586A (en) 1984-04-10
BE897365A (en) 1983-11-14
GB8319437D0 (en) 1983-08-17
ES524706A0 (en) 1985-01-01
PT77025A (en) 1983-08-01
GB2127014A (en) 1984-04-04
IT8222730A0 (en) 1982-08-04
ES8502436A1 (en) 1985-01-01
DE3327080A1 (en) 1984-02-09
GB2127014B (en) 1985-10-02
PT77025B (en) 1986-01-24

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WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid