KR840004715A - Method for preparing phenoxy alkylcarboxylic acid derivative - Google Patents

Abstract

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Description

Method for preparing phenoxy alkylcarboxylic acid derivative

Since this is an open matter, no full text was included.

Claims (21)

(a) R ₄ is lower alkyl, Z is lower alkylene or — (CH ₂ ) _s — [— O (CH ₂ ) _s ]] _t — group and R, R ₁ , R ₂ , R ₃ , R ₄ , R ₅ , n, s and t are compounds represented by the following general formula III (a) or II (b) to prepare compounds of general formula (I) as described below. or (b) R ₄ is lower alkyl, Z is 2-hydroxy-propylene, and R, R ₁ , R ₂ , R ₃ , R ₄ , R ₅ and n are described later. To prepare a compound of formula (I) as described above, the compound of formula III (a) or II (c) is reacted with formulas III (b) and II (c), respectively, or (c) R ₄ Is hydrogen and R, R ₁ , R ₂ , R ₃ , R ₄ , R ₅ Z and n are the corresponding general formula wherein R ₄ is lower alkyl to prepare a compound of formula (I) as described below. Hydrolyze the compound of (I) and, if necessary, (d) transfer the compound obtained according to step (c) to a salt with a liquid-toxic base. A process for preparing a salt with a pharmaceutically toxic base when the compound of formula (I) and R ₄ are hydrogen, characterized by cyclization. Wherein R and R ₁ are hydrogen or lower alkyl, R ₂ is lower alkinoyl, R ₃ is hydrogen or methyl, R ₄ is hydrogen or lower alkyl, and R ₅ is hydrogen, halogen, lower alkyl or Lower alkanoyl, Z is lower alkylene, 2-hydroxypropylene or — (CH ₂ ) _S — [O (CH ₂ ) _S —] — ^t group, Z is lower alkylene, 2-hydroxy propylene or — (CH ₂ ) using as a starting material a compound of the general formula III (a) or II (b) wherein A is halogen. _{) s -O- (CH 2) s} - group of the formula (Preparation method of ⅰ) compound. The method of claim 1 wherein Z is lower alkylene or 2-hydroxypropylene. The method of claim 1, wherein — (CH ₂ ) _S — [O (CH ₂ ) _S —] — is a ^t group, s is 2,3 or 4 and t is 1,2 or 3. 5. The method of claim 1, wherein R is lower alkyl. The method of any one of claims 1-5, wherein R ₁ is lower alkyl. The method of any one of claims 1 to 6, wherein R ₂ is at the 4 position. 8. The method of claim 1, wherein R ₃ is hydrogen. The method of claim 1, wherein R ₄ is hydrogen. 10. The method of any one of claims 1-9, wherein R ₅ is hydrogen. The method of any one of claims 1 to 10, wherein n is 1 or 3. The process according to claim 1, wherein [4-acetyl-3] [3 (4-acetyl-3-hydroxy-2-propylphenoxy) propoxy] -2-propylphenoxy] acetic acid is produced. The process according to claim 1, wherein a racemic [4-acetyl-3- [3- (4-acetyl-3-hydroxy-2-propylphenoxy) -2-hydroxy] -2-propylphenoxy] acetic acid is prepared. How to. The process according to claim 1, wherein 4- [4-acetyl-3] [3- (4-acetyl-3-hydroxy-2-propylphenoxy) propoxy] -2-propylphenoxy] butanoic acid is prepared. . The method according to claim 1, wherein [4-acetyl-3] [5- (4-acetyl-3-hydroxy-2-propylphenoxy) pentyloxy] -2-propylphenoxy] acetic acid is produced. The process according to claim 1, wherein [4-acetyl-3] [3- (4-acetyl-6-chloro-3-hydroxy-2-propylphenoxy) -propoxy] -2-propylphenoxy] acetic acid is prepared. How to. The compound according to claim 1, wherein 4- [4-acetyl-3] [[5- (4-acetyl-3-hydroxy-2-propylphenoxy) phene] -tyl octa] -2-propylpropyl oxy] butanoic acid How to prepare. The method according to claim 1, wherein [4-acetyl-3] [2--2- (4-acetyl-3-hydroxy-2-propylphenoxy) ethoxy] ethoxy] -2-propylphenoxy] acetic acid How to manufacture. The method according to claim 1, wherein [4-acetyl-3] [2--2- [2- (4-acetyl-3-hydroxy-2-propylphenoxy) ethoxy] ethoxy] -2-propylphenoxy A method of producing acetic acid. The method according to claim 1, wherein [4-acetyl-3] [2--2- [2--2- [2- (4-acetyl-3-hydroxy-2-propylphenoxy) ethoxy] ethoxy] ethoxy] -2-propylphenoxy] acetic acid. The method according to claim 1, wherein 4- [4-acetyl-3] [3- (3- (4-acetyl-3-hydroxy-2-propylphenoxy) propoxy] -2-propoxy] propylphenoxybuta How to prepare acid. ※ Note: It is to be disclosed based on the initial application.