KR840002906A - Dihydro- and tetrahydromonacoline L, and esters and metal salts thereof and processes for their preparation - Google Patents

Dihydro- and tetrahydromonacoline L, and esters and metal salts thereof and processes for their preparation Download PDF

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Publication number
KR840002906A
KR840002906A KR1019820005635A KR820005635A KR840002906A KR 840002906 A KR840002906 A KR 840002906A KR 1019820005635 A KR1019820005635 A KR 1019820005635A KR 820005635 A KR820005635 A KR 820005635A KR 840002906 A KR840002906 A KR 840002906A
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represented
tetrahydromonacoline
dihydro
general formula
dihydromonacoline
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KR1019820005635A
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Korean (ko)
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아끼라 엔도오
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아끼라 엔도오
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)

Abstract

내용 없음No content

Description

디히드로-및 테트라히드로모나콜린 L, 그리고 그것의 에스테르와 금속염들 및 이들의 제조방법Dihydro- and tetrahydromonacoline L, and esters and metal salts thereof and processes for their preparation

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 디히드로모나콜린 L의 적외선 흡수 스펙트럼(KBr).1 is the infrared absorption spectrum (KBr) of dihydromonacoline L.

제2도는 디히드로모나콜린 L의 NMR 스펙트럼(CDCl3).2 is NMR spectrum of dihydromonacoline L (CDCl 3 ).

제3도는 디히드로모나콜린 L의 질량분석 스펙트럼.3 shows the mass spectrometry of dihydromonacoline L.

Claims (12)

X가 -CH=CH- 또는 -CH2-CH2-를 뜻하는 일반식(Ⅰ)Formula (I), wherein X represents -CH = CH- or -CH 2 -CH 2- 에 의해 표시되는 디히드로-및 테트라히드로모나콜린 L과 Y가(M은 금속원소이고, n은 상기 금속원소의 원자가 이다) 또는 1내지 6개의 탄소원자들을 가진 알킬기를 뜻하고, X는 상기와 같은 뜻을 가지는 일반식(Ⅱ)Dihydro- and tetrahydromonacoline L and Y represented by (M is a metal element, n is the valence of the metal element) or an alkyl group having 1 to 6 carbon atoms, X is the general formula (II) having the same meaning as above 에 의해 표시되는 디히드로-및 테트라히드로모나콜린 L의 금속 카르복시산 염과 알킬 카르복시산 에스테르.Metal carboxylic acid salts and alkyl carboxylic acid esters of dihydro- and tetrahydromonacoline L represented by: 제1항에 있어서, 일반식(Ⅰ)에서의 X가 -CH=CH-인 일반식(Ⅲ)The general formula (III) according to claim 1, wherein X in general formula (I) is -CH = CH-. 에 의해 표시되는 디히드로모나콜린 L.Dihydromonacoline L, represented by 제1항에 있어서, 일반식(Ⅰ)에서의 X가 -CH2-CH2-인 일반식(Ⅳ)The general formula (IV) according to claim 1, wherein X in general formula (I) is -CH 2 -CH 2- . 에 의해 표시되는 테트라히드로모나콜린 L.Tetrahydromonacoline L represented by. 제1항에 있어서, 카르복시산염이 나트륨, 염칼슘염 또는 알루미늄염인 디히드로-및 테트라히드로모나콜린 L의 금속 카르복시산염.The metal carboxylate of dihydro- and tetrahydromonacoline L according to claim 1, wherein the carboxylate is sodium, calcium salt or aluminum salt. 제1항에 따른 디히드로-및 테트라히드로모나콜린 L의 금속 카르복시산 에스테르.Metal carboxylic acid esters of dihydro- and tetrahydromonacoline L according to claim 1. 모나스커스 속에 속하는 디히드로모나콜린 L-생성 미생물을 영양배지 위에서 배양시키는 것과 생성된 디히드로모나콜린 L을 분리시키는 것을 포함하는 일반식(Ⅲ)Formula (III) comprising culturing dihydromonacoline L-producing microorganism belonging to the genus Monascus on a nutrient medium and separating the resulting dihydromonacoline L 에 의해 표시되는 디히드로모나콜린 L의 제조방법.The manufacturing method of dihydromonacoline L represented by 제6항에 있어서, 모나스커스 속에 속하는 디히드로모나콜린 L-생성 미생물이 모나스커스 루버인 방법.The method of claim 6, wherein the dihydromonacoline L-producing microorganism belonging to the genus Monascus is Monascus louver. 제7항에 있어서, 모나스커스 루버가 모나스커스 루버 No. 1005(FERM-P 4822, ATCC 20657)인 방법.The method of claim 7, wherein the Monascus louver is a Monascus louver No. 1005 (FERM-P 4822, ATCC 20657). 유기용매 내에서 모나콜린 L, 또는 디히드로모나콜린 L 또는 이들의 알킬 카르복시산 에스테르를 촉매반응으로 환원시키는 것을 포함하는 일반식(Ⅳ)Formula IV comprising catalysis of monacoline L, or dihydromonacoline L or alkyl carboxylic acid esters thereof in an organic solvent. 에 의해 표시되는 테트라히드로모나콜린 L 또는 R이 1내지 6개의 탄소원자들을 가지는 알킬기를 뜻하는 일반식(Ⅴ).Formula (V) wherein tetrahydromonacoline L or R represented by is an alkyl group having 1 to 6 carbon atoms. 에 의해 표시되는 그것의 알킬 카르복시산 에스테르의 제조를 위한 방법.Process for the preparation of its alkyl carboxylic esters represented by X가 -CH=CH- 또는 -CH2-CH2-를 뜻하는 일반식(Ⅰ)Formula (I), wherein X represents -CH = CH- or -CH 2 -CH 2- 에 의해 표시되는 디히드로-또는 테트라히드로모나콜린 L을 유기용매에 용해시키고 상기의 용해된 화합물을 1내지 6개의 탄소원자들을 가지는 지방족 알코올 또는 M이 금속원소이고, n이 상기 금속원소의 원자가를 뜻하는 일반식(Ⅷ).The dihydro- or tetrahydromonacoline L represented by is dissolved in an organic solvent and the dissolved compound is an aliphatic alcohol having 1 to 6 carbon atoms or M is a metal element, and n is the valence of the metal element General formula (Ⅷ) means. M(OH)n (Ⅷ)M (OH) n (Ⅷ) 에 의해 표시되는 수산화금속과 반응시키는 것을 포함하는 Y가(M과 n이 뜻하는 바는 상기와 같다) 또는 1내지 6개의 탄소원자를 가지는 알킬기를 뜻하며; X는 상기와 같은 뜻을 가지는 일반식(Ⅶ)Y comprising reacting with a metal hydroxide represented by (M and n mean the same as above) or an alkyl group having 1 to 6 carbon atoms; X is a general formula having the same meaning as above 에 의해 표시되는 디히드로-또는 테트라히드로모나콜린 L의 금속 카르복시산염 또는 알킬 카르복시산에스테르의 제조방법.A method for producing a metal carboxylate or alkyl carboxylic acid ester of dihydro- or tetrahydromonacoline L represented by. 유효성분으로서 제1항의 화합물을 함유하는 과지방혈증 치료제.A therapeutic agent for hyperlipidemia containing the compound of claim 1 as an active ingredient. 제1항의 화합물을 효과적인 투여량으로 인간에게 투여하는 것을 포함하는 과지방혈증 치료방법.A method of treating hyperlipidemia comprising administering to a human at an effective dose the compound of claim 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820005635A 1981-12-23 1982-12-16 Dihydro- and tetrahydromonacoline L, and esters and metal salts thereof and processes for their preparation KR840002906A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1982.2.17?81-214788 1981-12-23
JP56214788A JPS58109480A (en) 1981-12-23 1981-12-23 Novel physiologically active substance, dihydromonacolin l and its preparation

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KR840002906A true KR840002906A (en) 1984-07-21

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