KR840001592A - Method for preparing 3'-deamino flexible body of glycoside anthracycline antibiotic - Google Patents

Method for preparing 3'-deamino flexible body of glycoside anthracycline antibiotic Download PDF

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Publication number
KR840001592A
KR840001592A KR1019820004213A KR820004213A KR840001592A KR 840001592 A KR840001592 A KR 840001592A KR 1019820004213 A KR1019820004213 A KR 1019820004213A KR 820004213 A KR820004213 A KR 820004213A KR 840001592 A KR840001592 A KR 840001592A
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KR
South Korea
Prior art keywords
glycoside
deamino
formula
iii
anthracycline antibiotic
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KR1019820004213A
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Korean (ko)
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KR880001573B1 (en
Inventor
카시넬리 기우세페 (외 2)
Original Assignee
기오르기오 오르란도
파르미탈리아 카를로 에르바 에스. 피. 에이
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Application filed by 기오르기오 오르란도, 파르미탈리아 카를로 에르바 에스. 피. 에이 filed Critical 기오르기오 오르란도
Publication of KR840001592A publication Critical patent/KR840001592A/en
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Publication of KR880001573B1 publication Critical patent/KR880001573B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음No content

Description

글리코시드 안트라사이클린 항생물질의 3′-데아미노 유연체의 제조방법Method for preparing 3′-deamino flexible body of glycoside anthracycline antibiotic

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

3′, 4′-디에피-다우노루비신 염산염 또는 3′, 4′-디에피-독소루비신 염산염의 수용액을 약 0℃에서 나트륨니트라이트와 1N 수성 아세트산과 반응시켜 수득되는(a) 하기 일반식(Ⅰ)에 있어서 R1=H이고 R2가 하기 구조식(Ⅱ) 또는 하기 구조식(Ⅲ)인 글리코시드와 (b) 일반식(Ⅰ)에 있어서 R1=OH이고 R2가 구조식(Ⅱ) 또는 구조식(Ⅲ)인 글리코시드와 탈아미노화 혼합물을 용리제로서 처음에는 클로로포름, 다음에는 클로로포름-아세톤(97 : 3 용적/용적) 혼합물을 사용하여 실리카겔상에서 크로마토그래피 분리를 행함으로서 일반식(Ⅰ)의 각각의 화합물을 순수한 형태의 유리염기로 회수함을 특징으로 하여 일반식(Ⅰ)의 글리코시드 안트라사이클린 항생물질의 3′-데아미노 유연체를 제조하는 방법.Obtained by reacting an aqueous solution of 3 ′, 4′-diepi-daunorubicin hydrochloride or 3 ′, 4′-diepi-doxorubicin hydrochloride at about 0 ° C. with sodium nitrite and 1N aqueous acetic acid (a) Glycoside of R < 1 > H in (I) and R <2> is following structural formula (II) or (III), and (b) R < 1 > OH and R <2> is structural formula (II) in general formula (I). Or by performing chromatographic separation on silica gel using a mixture of glycosides of formula (III) and a deaminoation as eluent, first with chloroform and then with chloroform-acetone (97: 3 vol / vol) mixture. (3) -deamino analogue of glycoside anthracycline antibiotic of general formula (I), characterized by recovering each compound of 상기식에서,In the above formula, R1은 수소 또는 히드록시이고,R 1 is hydrogen or hydroxy, R2는 다음 구조식(Ⅱ) 또는 (Ⅲ)이다.R 2 is the following structural formula (II) or (III). 제1항에 있어서, 반응을 약 3시간동안 수행하는 방법.The method of claim 1 wherein the reaction is carried out for about 3 hours. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR8204213A 1981-09-18 1982-09-17 Preparation process for antracycline glycoside KR880001573B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8128252 1981-09-18
IT8128252 1981-09-18
GB8128252 1981-09-18

Publications (2)

Publication Number Publication Date
KR840001592A true KR840001592A (en) 1984-05-07
KR880001573B1 KR880001573B1 (en) 1988-08-23

Family

ID=10524593

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204213A KR880001573B1 (en) 1981-09-18 1982-09-17 Preparation process for antracycline glycoside

Country Status (24)

Country Link
JP (1) JPS5862184A (en)
KR (1) KR880001573B1 (en)
AU (1) AU549656B2 (en)
BE (1) BE894418A (en)
CA (1) CA1184903A (en)
CH (1) CH654014A5 (en)
CS (1) CS236682B2 (en)
DE (1) DE3233898A1 (en)
DK (1) DK157030C (en)
ES (1) ES515690A0 (en)
FI (1) FI823169L (en)
FR (1) FR2513255A1 (en)
GR (1) GR77639B (en)
HU (1) HU186971B (en)
IE (1) IE53330B1 (en)
IL (1) IL66775A (en)
IT (1) IT1210481B (en)
NL (1) NL8203548A (en)
NO (1) NO153335C (en)
NZ (1) NZ201899A (en)
PT (1) PT75575B (en)
SE (1) SE456587B (en)
YU (1) YU204982A (en)
ZA (1) ZA826806B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides

Also Published As

Publication number Publication date
NL8203548A (en) 1983-04-18
DK157030C (en) 1990-04-02
FR2513255A1 (en) 1983-03-25
SE8205288L (en) 1983-03-19
AU549656B2 (en) 1986-02-06
IT1210481B (en) 1989-09-14
PT75575B (en) 1984-12-10
SE8205288D0 (en) 1982-09-15
DE3233898C2 (en) 1988-01-28
HU186971B (en) 1985-10-28
DK157030B (en) 1989-10-30
ZA826806B (en) 1983-07-27
NZ201899A (en) 1985-09-13
GR77639B (en) 1984-09-25
PT75575A (en) 1982-10-01
AU8832382A (en) 1983-03-24
FI823169L (en) 1983-03-19
NO823148L (en) 1983-03-21
NO153335C (en) 1986-02-26
CH654014A5 (en) 1986-01-31
DK411382A (en) 1983-03-19
IL66775A (en) 1986-11-30
ES8400120A1 (en) 1983-10-16
FR2513255B1 (en) 1984-11-30
CS236682B2 (en) 1985-05-15
IL66775A0 (en) 1982-12-31
BE894418A (en) 1983-01-17
FI823169A0 (en) 1982-09-14
JPS6260396B2 (en) 1987-12-16
JPS5862184A (en) 1983-04-13
NO153335B (en) 1985-11-18
IE822246L (en) 1983-03-18
IT8223240A0 (en) 1982-09-14
CA1184903A (en) 1985-04-02
DE3233898A1 (en) 1983-04-07
KR880001573B1 (en) 1988-08-23
ES515690A0 (en) 1983-10-16
YU204982A (en) 1985-03-20
SE456587B (en) 1988-10-17
IE53330B1 (en) 1988-10-12

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