IE822246L - Anthracycline glycosides - Google Patents
Anthracycline glycosidesInfo
- Publication number
- IE822246L IE822246L IE822246A IE224682A IE822246L IE 822246 L IE822246 L IE 822246L IE 822246 A IE822246 A IE 822246A IE 224682 A IE224682 A IE 224682A IE 822246 L IE822246 L IE 822246L
- Authority
- IE
- Ireland
- Prior art keywords
- doxorubicin
- image
- analogues
- anthracycline glycosides
- murine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Antitumour anthracycline glycosides of the formula <IMAGE> in which R1 is hydrogen or hydroxyl and R2 is alpha -L-pyranosylhexose (II) or (III) <IMAGE> are obtained by deamination of 3',4'-diepi analogues of daunorubicin and doxorubicin in a cold acidic medium such as 1N aqueous acetic acid, and at 0 DEG C, with NaNO2. In this series of anthracyclines, the doxorubicin analogues have on parenteral administration an antileukaemic activity against murine leukaemias which is comparable to or better than that of doxorubicin. They are also active against Gross murine leukaemia on oral administration.
[FR2513255A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8128252 | 1981-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE822246L true IE822246L (en) | 1983-03-18 |
| IE53330B1 IE53330B1 (en) | 1988-10-12 |
Family
ID=10524593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2246/82A IE53330B1 (en) | 1981-09-18 | 1982-09-15 | Anthracycline glycosides |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5862184A (en) |
| KR (1) | KR880001573B1 (en) |
| AU (1) | AU549656B2 (en) |
| BE (1) | BE894418A (en) |
| CA (1) | CA1184903A (en) |
| CH (1) | CH654014A5 (en) |
| CS (1) | CS236682B2 (en) |
| DE (1) | DE3233898A1 (en) |
| DK (1) | DK157030C (en) |
| ES (1) | ES515690A0 (en) |
| FI (1) | FI823169L (en) |
| FR (1) | FR2513255A1 (en) |
| GR (1) | GR77639B (en) |
| HU (1) | HU186971B (en) |
| IE (1) | IE53330B1 (en) |
| IL (1) | IL66775A (en) |
| IT (1) | IT1210481B (en) |
| NL (1) | NL8203548A (en) |
| NO (1) | NO153335C (en) |
| NZ (1) | NZ201899A (en) |
| PT (1) | PT75575B (en) |
| SE (1) | SE456587B (en) |
| YU (1) | YU204982A (en) |
| ZA (1) | ZA826806B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1506200A (en) * | 1975-04-30 | 1978-04-05 | Farmaceutici Italia | Glycosides |
-
1982
- 1982-09-13 YU YU02049/82A patent/YU204982A/en unknown
- 1982-09-13 NL NL8203548A patent/NL8203548A/en not_active Application Discontinuation
- 1982-09-13 NZ NZ201899A patent/NZ201899A/en unknown
- 1982-09-13 AU AU88323/82A patent/AU549656B2/en not_active Ceased
- 1982-09-13 DE DE19823233898 patent/DE3233898A1/en active Granted
- 1982-09-13 IL IL66775A patent/IL66775A/en unknown
- 1982-09-14 FI FI823169A patent/FI823169L/en not_active Application Discontinuation
- 1982-09-14 CA CA000411403A patent/CA1184903A/en not_active Expired
- 1982-09-14 IT IT8223240A patent/IT1210481B/en active
- 1982-09-14 ES ES515690A patent/ES515690A0/en active Granted
- 1982-09-14 FR FR8215507A patent/FR2513255A1/en active Granted
- 1982-09-15 CH CH5463/82A patent/CH654014A5/en not_active IP Right Cessation
- 1982-09-15 SE SE8205288A patent/SE456587B/en not_active IP Right Cessation
- 1982-09-15 CS CS826643A patent/CS236682B2/en unknown
- 1982-09-15 IE IE2246/82A patent/IE53330B1/en unknown
- 1982-09-15 DK DK411382A patent/DK157030C/en not_active IP Right Cessation
- 1982-09-16 BE BE0/209035A patent/BE894418A/en not_active IP Right Cessation
- 1982-09-16 ZA ZA826806A patent/ZA826806B/en unknown
- 1982-09-16 NO NO823148A patent/NO153335C/en unknown
- 1982-09-16 JP JP57159743A patent/JPS5862184A/en active Granted
- 1982-09-17 KR KR8204213A patent/KR880001573B1/en active
- 1982-09-17 HU HU822977A patent/HU186971B/en not_active IP Right Cessation
- 1982-09-17 GR GR69302A patent/GR77639B/el unknown
- 1982-09-17 PT PT75575A patent/PT75575B/en unknown
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