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세파로스포란산 유도체의 라이신염의 제조방법Method for preparing lysine salt of Sepharoseporanic acid derivative
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (3)
본 발명은 다음 구조식(II)로 표시되는 세파클로 또는 세프록시딘을 유기용매하에서 다음 구조식(III)인 40% 수용성 L-라이신을 반응시켜 분산용매하에서 침전시켜 다음 구조식 (I)로 표시되는 수용성 세파클로 또는 세프록사딘인 세파로스표린 유도체의 리이신염의 제조방법.The present invention reacts 40% water-soluble L-lysine, which is the next structural formula (III), in the organic solvent, and then precipitates it in a dispersing solvent. A process for preparing lysine salts of Sepharose and Serine derivatives that are Sephaclo or Ceproxadine.상기 식에서In the above formulaR은 페닐 또는 1,4-싹이클로핵사디엘이며, W는 염소 또는 메톡시기이다.R is phenyl or 1,4-sproutlonuclediel and W is a chlorine or methoxy group.제1항에 있어서, 반응용매를 메탄올, 에탄올, 이소프로판올, 이세톤등을 사용하며 침전시 분산용매로는 석유에테르, 에테르, n-헥산, n-헵탄을 사용하는 제조방법.The process according to claim 1, wherein the reaction solvent is methanol, ethanol, isopropanol, isetone, and the like, and petroleum ether, ether, n-hexane, n-heptane is used as a dispersion solvent during precipitation.제1항에 있어서, 침전시 온도는 40-45℃로 하는 제조방법.The process according to claim 1, wherein the precipitation temperature is 40-45 ° C.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820000996A1982-03-081982-03-08
Method for preparing lysine salt of Sepharoseporanic acid derivative
KR830009123A
(en)