KR830007516A - 폴리펩타이드 조성물 - Google Patents

폴리펩타이드 조성물 Download PDF

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Publication number
KR830007516A
KR830007516A KR1019810003518A KR810003518A KR830007516A KR 830007516 A KR830007516 A KR 830007516A KR 1019810003518 A KR1019810003518 A KR 1019810003518A KR 810003518 A KR810003518 A KR 810003518A KR 830007516 A KR830007516 A KR 830007516A
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KR
South Korea
Prior art keywords
glu
lys
val
polypeptide
general formula
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KR1019810003518A
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English (en)
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허버트 맥그리거 윌리암
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죠르쥬 드 모트
아메리칸 홈 프로덕트스 코포레이션
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Application filed by 죠르쥬 드 모트, 아메리칸 홈 프로덕트스 코포레이션 filed Critical 죠르쥬 드 모트
Publication of KR830007516A publication Critical patent/KR830007516A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C07K7/062—Serum thymic factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/18—Thymus derived hormone or factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

폴리펩타이드 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 다음 일반식(Ⅰ)의 폴리펩타이드의 보호된 중간물질을 탈보호시킴을 특징으로 하여 일반식(Ⅰ)의 폴리펩타이드 및 이들의 약학적으로 무독한 염을 제조하는 방법.
    R1―Lys―Lys―X―R2(Ⅰ)
    상기 일반식에서
    R1은 수소 또는 p-Glu
    X는 Glu 또는 Asp
    R2는 Val, NH2, 또는 Val―NH2을 나타낸다.
  2. 제1항에 있어서 보호된 중간물질이 펩타이드 수지 중간물질이며 일반식(Ⅰ)의 폴리펩타이드는 탈보호시켜 수지로부터 분리시켜 일반식(Ⅰ)의 폴리펩타이드 및 이들의 약학적으로 무독한 염을 제조하는 방법.
  3. 제1항에 있어서 필요한 경우 보호시킨거나 또는 활성화시킨 필요한 아미노산/아미드를 축합시켜 원하는 서열의 폴리펩타이드를 얻고 이것을 탈보호시켜 일반식(Ⅰ)의 폴리펩타이드 및 이들의 약학적으로 무독한 염을 제조하는 방법.
  4. 제1항에 있어서 필요한 경우 보호시킨거나 또는 활성화 시킨 필요한 아미노산 아미드를 고체상태서 수지 지지체상에서 축합시켜 펩타이드 수지 중간물질을 얻고 이 수지로부터 일반식(Ⅰ)의 폴리펩타이드를 분리시켜 일반식(Ⅰ)의 폴리펩타이드 및 이들의 약학적으로 무독한 염을 제조하는 방법.
  5. 제1항 내지 4항중 어느 하나에 있어서 제조된 폴리펩타이드가 p―Glu―Lys―Lys―Glu―Val―NH2또는 이들의 약학적으로 무독한 염인 방법.
  6. 제1항 내지 5항에 있어서 제조된 폴리펩타이드가 p―Glu―Lys―Lys―Glu―NH2또는 이들의 약학적으로 무독한 염인 방법.
  7. 제1항 내지 6항에 있어서 제조된 폴리펩타이드가 H―Lys―Lys―Glu―Val―NH2또는 이들의 약학적으로 무독한 염인 방법.
  8. 제1항 내지 7항에 있어서 제조된 폴리펩타이드가 H―Lys―Lys―Glu―NH2또는 이들의 약학적으로 무독한 염인 방법.
  9. 제1항 내지 8항에 있어서 제조된 폴리펩타이드가 H―Lys―Lys―Asp―Glu―Val―NH2또는 이들의 약학적으로 무독한 염인 방법.
  10. 제1항 내지 9항에 있어서 제조된 폴리펩타이드가 H―Lys―Lys―Glu―Val 또는 이들의 약학적으로 무독한 염인 방법.
  11. 제2항에 있어서 펩타이드 수지 중간물질이 다음 일반식의 화합물인 방법.
    상기 일반식에서
    R1은 수소 또는 p-Glu;
    X는 Glu 또는 Asp;
    R2는 Val, NH2, 또는 Val―NH2;
    A는 아미노보호그룹
    B는 카복시보호그룹이다.
  12. 제2항에 있어서 펩타이드 수지 중간물질이 다음 일반식의 화합물인 방법.
    상기 일반식에서
    R1은 수소 또는 p-Glu;
    X는 Glu 또는 Asp;
    R2는 Val, NH2, 또는 Val―NH2;
    A는 2―클로로벤질을옥시카보닐
    B는 벤질이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810003518A 1980-09-19 1981-09-18 폴리펩타이드 조성물 KR830007516A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18880480A 1980-09-19 1980-09-19
US06/286,138 US4361673A (en) 1980-09-19 1981-07-27 Polypeptide compositions
US286,138 1981-07-27
US188,804 1988-05-02

Publications (1)

Publication Number Publication Date
KR830007516A true KR830007516A (ko) 1983-10-21

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ID=26884483

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003518A KR830007516A (ko) 1980-09-19 1981-09-18 폴리펩타이드 조성물

Country Status (16)

Country Link
US (1) US4361673A (ko)
EP (1) EP0048573B1 (ko)
KR (1) KR830007516A (ko)
AR (1) AR229034A1 (ko)
AU (1) AU542630B2 (ko)
CA (1) CA1186303A (ko)
DE (1) DE3165244D1 (ko)
DK (1) DK410481A (ko)
ES (1) ES505610A0 (ko)
FI (1) FI812822L (ko)
GB (1) GB2086910B (ko)
GR (1) GR74352B (ko)
IE (1) IE51557B1 (ko)
IL (1) IL63824A (ko)
PH (1) PH17269A (ko)
PT (1) PT73702B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3100974A1 (de) * 1980-01-18 1982-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente
EP0056594B1 (de) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunregulierender Wirkung und Thymosin-alpha-1-Fragmente
US4442031A (en) * 1981-10-15 1984-04-10 Hoffmann-La Roche Inc. Immunopotentiating peptides
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
EP0215805A1 (en) * 1985-01-18 1987-04-01 MERCK PATENT GmbH Immunoregulatory peptides
DK15888D0 (da) * 1988-01-14 1988-01-14 Carlsberg Biotechnology Ltd Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden
ATE136551T1 (de) * 1988-05-10 1996-04-15 Alpha 1 Biomedicals Inc Festphase-verfahren zur gewinnung von thymosin- alpha-1
NZ229004A (en) * 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity
US5036050A (en) * 1989-01-12 1991-07-30 Immunobiology Research Institute, Inc. Compositions containing thymopentin for topical treatment of skin disorders
IT1244548B (it) * 1991-02-06 1994-07-15 Poli Ind Chimica Spa Derivati della 5-oxo-l-prolina e loro applicazioni farmaceutiche
EP2427213B1 (en) * 2009-05-08 2015-04-01 Sciclone Pharmaceuticals, Inc. Alpha thymosin peptides as vaccine enhancers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079127A (en) * 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
US4250086A (en) * 1979-11-19 1981-02-10 Ortho Pharmaceutical Corporation Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2
DE2938420A1 (de) * 1979-09-22 1981-04-09 Hoechst Ag, 6000 Frankfurt Neue peptide und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
GR74352B (ko) 1984-06-26
DK410481A (da) 1982-03-20
GB2086910A (en) 1982-05-19
IL63824A0 (en) 1981-12-31
IL63824A (en) 1985-02-28
DE3165244D1 (en) 1984-09-06
IE51557B1 (en) 1987-01-07
FI812822L (fi) 1982-03-20
EP0048573B1 (en) 1984-08-01
EP0048573A2 (en) 1982-03-31
IE812159L (en) 1982-03-19
PT73702A (en) 1981-10-01
US4361673A (en) 1982-11-30
AU7540581A (en) 1982-03-25
ES8301898A1 (es) 1983-01-01
EP0048573A3 (en) 1982-08-11
AR229034A1 (es) 1983-05-31
AU542630B2 (en) 1985-02-28
CA1186303A (en) 1985-04-30
GB2086910B (en) 1983-12-21
PT73702B (en) 1982-12-10
ES505610A0 (es) 1983-01-01
PH17269A (en) 1984-07-03

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