KR830005231A - Method for preparing imidazole derivative - Google Patents

Method for preparing imidazole derivative Download PDF

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Publication number
KR830005231A
KR830005231A KR1019810001463A KR810001463A KR830005231A KR 830005231 A KR830005231 A KR 830005231A KR 1019810001463 A KR1019810001463 A KR 1019810001463A KR 810001463 A KR810001463 A KR 810001463A KR 830005231 A KR830005231 A KR 830005231A
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KR
South Korea
Prior art keywords
formula
compound
hydrogen
general formula
alkyl
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Application number
KR1019810001463A
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Korean (ko)
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KR840002140B1 (en
Inventor
데렁스 로마노
Original Assignee
쿠르트 네셀보쉬, 한스 스튀클린
에프·호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트
한스 스튀클린
에프.호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트
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Application filed by 쿠르트 네셀보쉬, 한스 스튀클린, 에프·호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트, 한스 스튀클린, 에프.호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트 filed Critical 쿠르트 네셀보쉬, 한스 스튀클린
Publication of KR830005231A publication Critical patent/KR830005231A/en
Application granted granted Critical
Publication of KR840002140B1 publication Critical patent/KR840002140B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음No content

Description

이미다졸 유도체의 제조방법Method for preparing imidazole derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

다음 일반식(Ⅱ)의 디케톤을 암모늄이온 함유 극성용매 존재하에서 다음 일반식(Ⅲ)의 알데히드와 반응시켜 X가 수소인 다음 일반식(Ⅰ)의 화합물을 제조하고, 또 X가 수소인 일반식(Ⅰ)의 화합물을 아실화 반응시켜 X가 C1-4알킬인 일반식(Ⅰ)의 화합물을 제조하고, 또 필요한 경우 Y가 유황인 일반식(Ⅰ)의 화합물을 산화시켜, Y가 설피닐인 일반식(Ⅰ)의 화합물을 제조하며, 또 필요한 경우 일반식(Ⅰ)의 화합물을 생리학적으로 적합한 산부가염으로 변환시키는 것을 특징으로 하여 다음 일반식(Ⅰ)의 이미다졸 유도체와 생리학적으로 허용되는 이들의 산부가염을 제조하는 방법.The diketone of the following general formula (II) is reacted with an aldehyde of the following general formula (III) in the presence of an ammonium ion-containing polar solvent to prepare a compound of the following general formula (I), wherein X is hydrogen, and X is hydrogen Acylating the compound of formula (I) to prepare a compound of formula (I) wherein X is C 1-4 alkyl, and if necessary, oxidizing a compound of formula (I) wherein Y is sulfur, A compound of formula (I), which is sulfinyl, is prepared, and if necessary, the compound of formula (I) is converted into a physiologically suitable acid addition salt. A method for preparing acid addition salts thereof, which is scientifically acceptable. 상기 일반식에서In the above general formula X는 수소 또는 C1-4알킬이고,X is hydrogen or C 1-4 alkyl, Y는 유황 또는 설피닐 또는 설포닐기이며, 또Y is sulfur or sulfinyl or sulfonyl group, and Z는 경우에 따라 메틸 또는 불소로 치환된 티에틸이거나 또는 상기 일반식(Z)의 기이다(단, 상기 일반식(Z)에서 R1,R2및 R3는 수소, 메틸, 불소, 하이드록시, 메톡시, 메틸티오이거나 또는 R1, R2및 R3중 2개는 인접 탄소원자상에서 합쳐서 메틸렌디옥시 또는 에틸렌디옥시이거나 또는 R1, R2및 R3중 1개는 모노- 또는 디-(C1-4알킬)-아미노이고 또 다른 2개는 수소이다).Z is optionally ethyl or ethyl substituted with fluorine or a group of formula (Z) wherein R 1 , R 2 and R 3 in formula (Z) are hydrogen, methyl, fluorine, Roxy, methoxy, methylthio or two of R 1 , R 2 and R 3 combined on adjacent carbon atoms are methylenedioxy or ethylenedioxy or one of R 1 , R 2 and R 3 is mono- or Di- (Ci_ 4 alkyl) -amino and the other two are hydrogen). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810001463A 1980-04-29 1981-04-28 Process for preparing imidazole derivatives KR840002140B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH330480 1980-04-29
CH3304180? 1980-04-29
CH3304/80 1980-04-29

Publications (2)

Publication Number Publication Date
KR830005231A true KR830005231A (en) 1983-08-03
KR840002140B1 KR840002140B1 (en) 1984-11-23

Family

ID=4253090

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810001463A KR840002140B1 (en) 1980-04-29 1981-04-28 Process for preparing imidazole derivatives

Country Status (5)

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JP (1) JPS56169693A (en)
KR (1) KR840002140B1 (en)
BR (1) BR8102576A (en)
GR (1) GR74885B (en)
ZA (1) ZA812641B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6064653B2 (en) * 2013-02-15 2017-01-25 東洋インキＳｃホールディングス株式会社 Fluorescent material, fluorescent resin composition and compound

Also Published As

Publication number Publication date
JPS56169693A (en) 1981-12-26
ZA812641B (en) 1982-04-28
GR74885B (en) 1984-07-12
BR8102576A (en) 1982-01-19
KR840002140B1 (en) 1984-11-23

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