KR830003503A - Method for preparing 7α-methoxycephalosporin - Google Patents

Abstract

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Description

Method for preparing 7α-methoxycephalosporin

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Claims (2)

A process for preparing a compound of formula (II) and esters, salts and amides thereof by reacting a compound of formula (III) or an ester, salt or amide thereof with a halogenating agent in the presence of methanol and an alkali metal salt of methanol. In the above structural formula A is a hydrogen atom, a halogen atom, an alkyl group, a hydroxyl group, an alkoxy group, an acetoxymethyl group or a heterocycle ring-substituted thiomethyl group, and R ₂ is a hydrocarbon residue. Following reaction of a compound of formula (III) or an ester, salt or amide thereof with a halogenating agent in the presence of methanol and an alkali metal salt of methanol, the resulting compound of formula (II) or an ester, salt or amide thereof Reacting with a thiol of IV) or a salt thereof to produce a compound of formula (I) or an ester, salt or amide thereof. In the above structural formula R ₁ is a lower alkyl group, an aralkyl group, an aryl group or a heterocycle ring containing one or more nitrogen, sulfur, or oxygen atoms which may be substituted with a halogen atom, a cyano group or a nitro group and is an aralkyl group, an aryl group and The heterocycle ring may be substituted with a lower alkyl group, halogen atom, cyano group, nitro group, hydroxy group or lower alkoxy group. R ₂ is a hydrocarbon residue, A is a hydrogen atom, a halogen atom, an alkyl group, a hydroxyl group, an alkoxy group, an acetoxymethyl group or a heterocyclic substituted thiomethyl group. ※ Note: The disclosure is based on the initial application.