KR830010120A - Process for preparing cefem compound - Google Patents

Process for preparing cefem compound Download PDF

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Publication number
KR830010120A
KR830010120A KR1019820001514A KR820001514A KR830010120A KR 830010120 A KR830010120 A KR 830010120A KR 1019820001514 A KR1019820001514 A KR 1019820001514A KR 820001514 A KR820001514 A KR 820001514A KR 830010120 A KR830010120 A KR 830010120A
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KR
South Korea
Prior art keywords
group
compound
substituted
protected
amino
Prior art date
Application number
KR1019820001514A
Other languages
Korean (ko)
Inventor
쯔도무 데라지
가즈오 사까네
지로오 고또오
Original Assignee
후지사와 유우 기찌로오
후지사와 야꾸힝 고교 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 후지사와 유우 기찌로오, 후지사와 야꾸힝 고교 가부시기 가이샤 filed Critical 후지사와 유우 기찌로오
Publication of KR830010120A publication Critical patent/KR830010120A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세펨 화합물의 제조방법Process for preparing cefem compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

하기 구조식(Ⅱ)의 화합물 혹은 그 염과 알맞은 치환체로 대치될 수 있는 하나이상의 질소원자를 함유하는 헤데로시클릭 화합물-NN과 반응시키고, 이 결과의 화합물(Ⅳ)를 카르복시-보호기의 제거반응에 가하는 단계로 구성되는 하기 구조식(Ⅰ)의 세펨화합물을 제조하는 방법.Reacting with a heterocyclic compound-NN containing at least one nitrogen atom, which can be substituted with a compound of formula (II) or a salt thereof and a suitable substituent, and the resulting compound (IV) is subjected to the removal of the carboxy-protecting group. Method for producing a cefem compound of formula (I) consisting of a step of adding. 윗식에서 R1은 아미노 혹은 보호된 아미노기,R2는 알맞는 치환체로 지환될 수 있는 저급 지방족 탄화수소기, 혹은 시클로(저급) 알케닐; R3는의 기로 치환될 수 있는 기; R4는 보호된 카르복시기;X 는산부분;는 알맞는 치환체로 치환될 수 있는 하나 이상의 질소 원자를 지니는 헤테로시클릭 양이온 기임.Wherein R 1 is an amino or protected amino group, R 2 is a lower aliphatic hydrocarbon group which may be substituted with a suitable substituent, or cyclo (lower) alkenyl; R 3 is A group which may be substituted with a group of; R 4 is a protected carboxy group; X is an acid moiety; Is a heterocyclic cation group having one or more nitrogen atoms which may be substituted with suitable substituents. 하기 구조식 (Ⅸ)의 화합물을 환원시켜서 하기 구조식(Ⅳ)의 화합물을 제조하는 방법.The method of manufacturing the compound of following formula (IV) by reducing the compound of following formula (VII). 윗식에서 R1은 아미노 혹은 보호된 아미노기, R2는 알맞는 치환체로 치환될 수 있는 저급 지방족 탄화수소기, 혹은 시클로(저급) 알케닐; R4는 보호된 카르복시기, X는 산부분,는 알맞는 치환체로 치환될 수 있는 하나 이상의 질소 원자를 지니는 헤테로 시클릭양이온 기임.Wherein R 1 is an amino or protected amino group, R 2 is a lower aliphatic hydrocarbon group which may be substituted with a suitable substituent, or cyclo (lower) alkenyl; R 4 is a protected carboxyl group, X is an acid moiety, Is a heterocyclic cation group having one or more nitrogen atoms which may be substituted with suitable substituents. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820001514A 1981-07-24 1982-04-03 Process for preparing cefem compound KR830010120A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB81-22896 1981-07-24
GB8122896 1981-07-24

Publications (1)

Publication Number Publication Date
KR830010120A true KR830010120A (en) 1983-12-26

Family

ID=55025774

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820001514A KR830010120A (en) 1981-07-24 1982-04-03 Process for preparing cefem compound

Country Status (1)

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KR (1) KR830010120A (en)

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