KR830002034A - Istamycin and its preparation - Google Patents

Abstract

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Description

Istamycin and its preparation

Since this is an open matter, no full text was included.

FIG. 1 shows the curve of the infrared absorption spectrum of an istomycin A hemi-carbonate sample granulated in potassium embrittlement,

FIG. 2 shows the curve of the infrared absorption spectrum of istamycin B hemi-carbonate sample globulized in potassium embrittlement,

FIG. 3 shows the curve of the erythroid absorption spectrum of istamycin A ₀ hemi-carbonate sample globulized in potassium embrittlement,

Figure 4 shows the curve of the infrared absorption spectrum of istamycin B ₀ hemi-carbonate sample globulized in potassium embrittlement.

Claims (19)

As detailed in the text Isamycin A represented by the following general formula: Istomycin B represented by the following general formula: Isamycin A ₀ represented by the general formula _: Or isamycin A ₀ represented by the general formula _: Istomycin B ₀ represented by the general formula _: And a new compound selected from acid addition salts thereof, isamycin. A compound of claim 1 which is isamycin A or an acid addition salt thereof. The compound of claim 1 which is istomycin B or an acid addition salt thereof. A compound of claim 1 which is isamycin A ₀ or an acid addition salt thereof. The compound of claim 1 which is isamycin B ₀ or an acid addition salt thereof. Preparation of antibiotics, itamycin complex, characterized in that by culturing the streptomas, which is a star mycin-producing seed in an incubator containing a carbon and nitrogen source under aerobic conditions until a substantial amount of itamycin is produced and accumulated in the incubator Way. The method of claim 6 having the step of recovering the itamycin complex from the incubator. The method of claim 6, wherein the estamycin-producing seed is made using Streptomyces tenzimarisis, such as FERM-P 4932 or ATCC No. 31603. A method for preparing istomycin A, characterized by culturing Streptomyces, which is an estamycin A-producing seed, in an incubator containing carbon and nitrogen sources under aerobic conditions until a substantial amount of itamycin A is produced and accumulated in the incubator. . Method for preparing istomycin B, characterized by culturing Streptomyces, which is an istamycin B-producing seed, in an incubator containing carbon and nitrogen sources under aerobic conditions until a substantial amount of itamycin B is produced and accumulated in the incubator . A method for preparing istomycin Ao, characterized by culturing Streptomyces, which is an istamycin Ao-producing seed, in an incubator containing carbon and nitrogen sources under aerobic conditions until a substantial amount of itamycin Ao is produced and accumulated in the incubator. . Method for preparing istomycin B, characterized by culturing Streptomyces, which is an istamycin Bo-producing seed, in an incubator containing carbon and nitrogen sources under aerobic conditions until a substantial amount of itamycin Bo is produced and accumulated in the incubator . The preparation of claims 9, 10, 11 or 12 for culturing Streptomycer tenzimariensis SS-939. The formulation of claim 9, 10, 11 or 12 comprising isolating istamycin A, isamycin B, isamycin Ao, isamycin Bo. A method for producing istamycin Ao from istamycin A by hydrolyzing isamycin A under alkaline conditions. A method for producing istasycin Bo from istomycin B by hydrolyzing isamycin B under alkaline conditions. A pharmaceutical composition comprising mixing a safe and effective antimicrobial amount of at least one of Istamycin A, Istamycin B, and a pharmaceutically acceptable acid addition salt thereof with a pharmaceutically acceptable carrier. A method of inhibiting bacterial growth by administering to the animal susceptible to bacterial growth a dose of at least one antimycolytically effective amount of Istamycin A, Istamycin B, and a pharmaceutically acceptable acid addition salt thereof. New microorganism, Streptomyces tenjimarienssis SS-939, identical to FERM-P 4932 or ATCC No. 31603. ※ Note: The disclosure is based on the initial application.