GB1462805A - Antibiotic and process for the preparation thereof - Google Patents
Antibiotic and process for the preparation thereofInfo
- Publication number
- GB1462805A GB1462805A GB1656974A GB1656974A GB1462805A GB 1462805 A GB1462805 A GB 1462805A GB 1656974 A GB1656974 A GB 1656974A GB 1656974 A GB1656974 A GB 1656974A GB 1462805 A GB1462805 A GB 1462805A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fortimicin
- antibiotic
- indicated
- micromonospora
- spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1462805 Fortimicin B ABBOTT LABORATORIES and KYOWA HAKKO KOGYO CO Ltd 16 April 1974 [17 April 1973] 16569/74 Headings C2A and C2C A process for producing the antibiotic Fortimicin B comprises culturing a microorganism belonging to the genus Micromonospora having the ability to produce Fortimicin B in a nutrient medium and accumulating Fortimicin B in said medium. Suitable microorganisms are Micromonospora olivoasterospora ATCC 21819, Micromonospora olivoasterospora ATCC 31009 and Micromonospora olivoasterospora ATCC 31010. Fortimicin B has a molecular weight of 348, a formula of C 15 H 32 N 4 O 5 ,a melting point of 101-103 C., an optical rotation [α] D <SP>24</SP> of 22À2 (C = 1À01, H 2 O) and is characterized by (a) a u.v. spectrum as indicated in Fig. 1 (not shown), (b) an infra-red spectrum as indicated in Fig. 2 (not shown) and (e) an nmr spectrum as indicated in Fig. 3 (not shown). The antibiotic is believed to have the following chemical structure Pharmaceutically non-toxic acid addition salts of the antibiotic may be prepared by known methods. The antibiotic or acid addition salt may be admixed with an inert carrier or diluent to form a pharmaceutical or disinfectant composition.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP48042696A JPS5246311B2 (en) | 1973-04-17 | 1973-04-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1462805A true GB1462805A (en) | 1977-01-26 |
Family
ID=12643199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1656974A Expired GB1462805A (en) | 1973-04-17 | 1974-04-16 | Antibiotic and process for the preparation thereof |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5246311B2 (en) |
| AR (1) | AR201860A1 (en) |
| AT (1) | AT329180B (en) |
| BE (1) | BE813772A (en) |
| CA (1) | CA1025384A (en) |
| CH (1) | CH590925A5 (en) |
| DE (1) | DE2418349C3 (en) |
| DK (1) | DK137864B (en) |
| ES (1) | ES425440A1 (en) |
| FR (1) | FR2226159B1 (en) |
| GB (1) | GB1462805A (en) |
| IN (1) | IN139126B (en) |
| NL (1) | NL157655B (en) |
| NO (1) | NO139864C (en) |
| PH (1) | PH12923A (en) |
| SE (1) | SE420214B (en) |
| ZA (1) | ZA742107B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5218888A (en) * | 1975-08-01 | 1977-02-12 | Kyowa Hakko Kogyo Co Ltd | Preparation of fortimicin c |
| JPS6011718B2 (en) * | 1976-09-23 | 1985-03-27 | 協和醗酵工業株式会社 | Novel hortimycin B derivative and its production method |
| US4091032A (en) * | 1976-09-23 | 1978-05-23 | Abbott Laboratories | 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A |
| JPS53141244A (en) * | 1977-05-11 | 1978-12-08 | Kyowa Hakko Kogyo Co Ltd | Novel hortemycin derivatives |
| US4219643A (en) * | 1979-03-29 | 1980-08-26 | Abbott Laboratories | Fortimicin AN |
| CN109897862B (en) * | 2019-02-03 | 2020-10-02 | 浙江海正药业股份有限公司 | Gentamicin B producing strain and preparation method and application thereof |
-
1973
- 1973-04-17 JP JP48042696A patent/JPS5246311B2/ja not_active Expired
-
1974
- 1974-04-02 ZA ZA00742107A patent/ZA742107B/en unknown
- 1974-04-05 PH PH15718A patent/PH12923A/en unknown
- 1974-04-08 NO NO741300A patent/NO139864C/en unknown
- 1974-04-10 CA CA197,234A patent/CA1025384A/en not_active Expired
- 1974-04-12 AT AT310274A patent/AT329180B/en not_active IP Right Cessation
- 1974-04-12 FR FR7412976A patent/FR2226159B1/fr not_active Expired
- 1974-04-16 DE DE2418349A patent/DE2418349C3/en not_active Expired
- 1974-04-16 DK DK206474AA patent/DK137864B/en not_active IP Right Cessation
- 1974-04-16 SE SE7405066A patent/SE420214B/en not_active IP Right Cessation
- 1974-04-16 NL NL7405105.A patent/NL157655B/en not_active IP Right Cessation
- 1974-04-16 BE BE143248A patent/BE813772A/en not_active IP Right Cessation
- 1974-04-16 GB GB1656974A patent/GB1462805A/en not_active Expired
- 1974-04-17 ES ES425440A patent/ES425440A1/en not_active Expired
- 1974-04-17 AR AR253326A patent/AR201860A1/en active
- 1974-04-17 CH CH530474A patent/CH590925A5/xx not_active IP Right Cessation
- 1974-06-07 IN IN1249/CAL/74A patent/IN139126B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2418349B2 (en) | 1979-08-16 |
| NL7405105A (en) | 1974-10-21 |
| FR2226159B1 (en) | 1977-07-01 |
| CH590925A5 (en) | 1977-08-31 |
| PH12923A (en) | 1979-10-10 |
| SE420214B (en) | 1981-09-21 |
| ATA310274A (en) | 1975-07-15 |
| IN139126B (en) | 1976-05-08 |
| AT329180B (en) | 1976-04-26 |
| ES425440A1 (en) | 1976-06-01 |
| DK137864B (en) | 1978-05-22 |
| DK137864C (en) | 1978-10-23 |
| CA1025384A (en) | 1978-01-31 |
| DE2418349A1 (en) | 1974-11-07 |
| JPS49126892A (en) | 1974-12-04 |
| AU6768374A (en) | 1975-10-09 |
| DE2418349C3 (en) | 1980-04-24 |
| NO139864C (en) | 1979-05-23 |
| NO741300L (en) | 1974-10-18 |
| ZA742107B (en) | 1975-04-30 |
| FR2226159A1 (en) | 1974-11-15 |
| AR201860A1 (en) | 1975-04-24 |
| JPS5246311B2 (en) | 1977-11-24 |
| BE813772A (en) | 1974-10-16 |
| NO139864B (en) | 1979-02-12 |
| NL157655B (en) | 1978-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |