KR830000247A - Sepharosporin antibiotic preparation method - Google Patents

Sepharosporin antibiotic preparation method

Info

Publication number
KR830000247A
KR830000247A KR1019770000335A KR770000335A KR830000247A KR 830000247 A KR830000247 A KR 830000247A KR 1019770000335 A KR1019770000335 A KR 1019770000335A KR 770000335 A KR770000335 A KR 770000335A KR 830000247 A KR830000247 A KR 830000247A
Authority
KR
South Korea
Prior art keywords
structural formula
following structural
sepharosporin
fur
primary
Prior art date
Application number
KR1019770000335A
Other languages
Korean (ko)
Other versions
KR830001543B1 (en
Inventor
그리그손 미카엘
브룩 스카이스 리카르드
Original Assignee
헤롤드 왈터 마틴
글락소 라보라 토리즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 헤롤드 왈터 마틴, 글락소 라보라 토리즈 filed Critical 헤롤드 왈터 마틴
Priority to KR7700335A priority Critical patent/KR830001543B1/en
Publication of KR830000247A publication Critical patent/KR830000247A/en
Application granted granted Critical
Publication of KR830001543B1 publication Critical patent/KR830001543B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세파로스포린 항생물질의 제조방법Sepharosporin antibiotic preparation method

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음This content is subject to disclosure, so the full text is not included.

Claims (9)

(A) (6R,7R)-3-카바모일옥시메틸-7-[(Z)-2-(푸르-2-일)-2-메톡시이미노아세트아미도]세프-3-엠-4-카복실산(즉, 세푸록심) 또는 그의 염을 다음 구조식(II)인 할로에스텔과 반응시키거나, 또는(A) (6R,7R)-3-carbamoyloxymethyl-7-[(Z)-2-(fur-2-yl)-2-methoxyiminoacetamido]cep-3-M-4 -Reacting a carboxylic acid (i.e. cefuroxime) or a salt thereof with a haloester having the following structural formula (II), or (B) 다음 구조식(III) 화합물 또는 그의 산부가염 또는 N-실릴유도체를 (Z)-2-(푸르-2-일)-2-메톡시이미노아세틴산 또는 그의 반응성이 큰 유도체로 아실화시킴을 특징으로 하는 다음 구조식(I)인 화합물의 제조방법.(B) acylation of the following structural formula (III) compound or its acid addition salt or N-silyl derivative with (Z)-2-(fur-2-yl)-2-methoxyiminoacetic acid or a highly reactive derivative Method for producing a compound of the following structural formula (I) characterized by sikim. t1 t1 상기 구조식에서In the above structural formula R1은 탄소수 1-4인 일급 또는 이급 알킬그룹이고,R 1 is a primary or secondary alkyl group having 1-4 carbon atoms, R2는 탄소수 1-6인 일급 또는 이급 알킬그룹이고 R1과 R2중의 적어도 하나는 메틸이고R 2 is a primary or secondary alkyl group having 1-6 carbon atoms, and at least one of R 1 and R 2 is methyl X는 할로겐이다.X is halogen. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed according to the contents of the initial application.
KR7700335A 1977-02-15 1977-02-15 Process for preparing cephalosporin antibiotics KR830001543B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR7700335A KR830001543B1 (en) 1977-02-15 1977-02-15 Process for preparing cephalosporin antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR7700335A KR830001543B1 (en) 1977-02-15 1977-02-15 Process for preparing cephalosporin antibiotics

Publications (2)

Publication Number Publication Date
KR830000247A true KR830000247A (en) 1983-03-30
KR830001543B1 KR830001543B1 (en) 1983-08-10

Family

ID=19203882

Family Applications (1)

Application Number Title Priority Date Filing Date
KR7700335A KR830001543B1 (en) 1977-02-15 1977-02-15 Process for preparing cephalosporin antibiotics

Country Status (1)

Country Link
KR (1) KR830001543B1 (en)

Also Published As

Publication number Publication date
KR830001543B1 (en) 1983-08-10

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