KR830000205A - Method for preparing 4-hydroxyphenyl alkanolamine derivative - Google Patents

Method for preparing 4-hydroxyphenyl alkanolamine derivative Download PDF

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Publication number
KR830000205A
KR830000205A KR1019770001479A KR770001479A KR830000205A KR 830000205 A KR830000205 A KR 830000205A KR 1019770001479 A KR1019770001479 A KR 1019770001479A KR 770001479 A KR770001479 A KR 770001479A KR 830000205 A KR830000205 A KR 830000205A
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South Korea
Prior art keywords
compound
hydrogen
aroyl
acid addition
addition salt
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KR1019770001479A
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Korean (ko)
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KR840001671B1 (en
Inventor
에버렛트 휘리온 리차아드
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윌리암 하우아드 죤슨
스터어링 드럭그 인코포레이팃드
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Application filed by 윌리암 하우아드 죤슨, 스터어링 드럭그 인코포레이팃드 filed Critical 윌리암 하우아드 죤슨
Priority to KR7701479A priority Critical patent/KR840001671B1/en
Priority to KR1019810004844A priority patent/KR830000224A/en
Publication of KR830000205A publication Critical patent/KR830000205A/en
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Publication of KR840001671B1 publication Critical patent/KR840001671B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton

Abstract

내용 없음No content

Description

4-히드록시페닐 알칸올아민 유도체의 제조방법Method for preparing 4-hydroxyphenyl alkanolamine derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음This content is subject to disclosure, so the full text is not included.

Claims (1)

유리 염기형의 일반식(II)의 화합물 또는 그의 산부가염을 환원시키고(여기서 출발 화합물중의 Y가 저급알카노일 또는 아로일이고, 케톤과 카복실산 에스테르 작용기를 양쪽 다 환원할 수 있는 환원제로 환원시킨 경우에는 생성화합물중의 Y는 수소이다), 소망에 따라, Y가 저급알카노일이나 아로일인 생성 화합물을 가수분해하여 Y가 H인 상응하는 화합물을 얻거나 또는 Y가 수소인 생성화합물을 에스테르화하여 Y가 저급알카노일이나 아로일인 상응하는 화합물을 얻고, 소망에 따라, Q가 저급 알킬티오인 생성화합물을 산화시켜 Q가 저급 알킬설피닐인 상응하는 화합물을 얻으며, 소망에 따라 생성된 유리 염기 화합물을 산부가염으로 전환시키거나 또는 Y가 수소인 생성화합물의 염기성염을 형성시킴을 특징으로 하는 유리염기형의 일반식(I)의 화합물 또는 그의 산부가염의 제조방법:Reducing the free basic compound of the general formula (II) or its acid addition salt (wherein Y in the starting compound is lower alkanoyl or aroyl, and reduced with a reducing agent capable of reducing both ketone and carboxylic acid ester functional groups. In this case, Y in the product compound is hydrogen), if desired, hydrolyze the product compound in which Y is lower alkanoyl or aroyl to obtain the corresponding compound in which Y is H, or esterify the product compound in which Y is hydrogen. To obtain the corresponding compound in which Y is lower alkanoyl or aroyl, and if desired, the product compound in which Q is lower alkylthio is oxidized to obtain the corresponding compound in which Q is lower alkylsulfinyl, and the free base produced as desired A method for preparing a free base compound of general formula (I) or an acid addition salt thereof, characterized by converting the compound to an acid addition salt or forming a basic salt of the product compound in which Y is hydrogen: 상기식중,Among the above formulas, R1,R2및 R3는 독립하여 수소 또는 저급 알킬기이고;R 1 , R 2 and R 3 are independently hydrogen or a lower alkyl group; n은 1-3의 정수이고;n is an integer from 1-3; Ar은 페닐 또는 1-3의 할로, 저급알킬, 히드록시 또는 저급 알콕시치환분을 가지는 페닐이고;Ar is phenyl or phenyl having 1-3 halo, lower alkyl, hydroxy or lower alkoxy substituents; Q는 저급 알킬티오, 저급 알킬설피닐 또는 저급 알킬설포닐이며;Q is lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; Y는 수소, 저급 알카노일, 아로일, 벤젠설포닐 또는 톨루엔설포닐이다.Y is hydrogen, lower alkanoyl, aroyl, benzenesulfonyl or toluenesulfonyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed according to the contents of the initial application.
KR7701479A 1977-06-25 1977-06-25 Process for the preparation of 4-hydroxy phenyl alkanolamine derivatives KR840001671B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR7701479A KR840001671B1 (en) 1977-06-25 1977-06-25 Process for the preparation of 4-hydroxy phenyl alkanolamine derivatives
KR1019810004844A KR830000224A (en) 1977-06-25 1981-12-10 Method for preparing 4-hydroxyphenyl alkanolamine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR7701479A KR840001671B1 (en) 1977-06-25 1977-06-25 Process for the preparation of 4-hydroxy phenyl alkanolamine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004844A Division KR830000224A (en) 1977-06-25 1981-12-10 Method for preparing 4-hydroxyphenyl alkanolamine derivative

Publications (2)

Publication Number Publication Date
KR830000205A true KR830000205A (en) 1983-03-30
KR840001671B1 KR840001671B1 (en) 1984-10-13

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KR7701479A KR840001671B1 (en) 1977-06-25 1977-06-25 Process for the preparation of 4-hydroxy phenyl alkanolamine derivatives
KR1019810004844A KR830000224A (en) 1977-06-25 1981-12-10 Method for preparing 4-hydroxyphenyl alkanolamine derivative

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019810004844A KR830000224A (en) 1977-06-25 1981-12-10 Method for preparing 4-hydroxyphenyl alkanolamine derivative

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Publication number Publication date
KR830000224A (en) 1983-03-30
KR840001671B1 (en) 1984-10-13

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