KR790000569B1 - Method of producting 62-fluoro-17,21-dehydroxy-16b-methylpregna-4,9(11)-diene-3,20-dione 17,21-diacetate - Google Patents

Method of producting 62-fluoro-17,21-dehydroxy-16b-methylpregna-4,9(11)-diene-3,20-dione 17,21-diacetate

Info

Publication number
KR790000569B1
KR790000569B1 KR7803115A KR780003115A KR790000569B1 KR 790000569 B1 KR790000569 B1 KR 790000569B1 KR 7803115 A KR7803115 A KR 7803115A KR 780003115 A KR780003115 A KR 780003115A KR 790000569 B1 KR790000569 B1 KR 790000569B1
Authority
KR
South Korea
Prior art keywords
dehydroxy
methylpregna
producting
diacetate
dione
Prior art date
Application number
KR7803115A
Other languages
Korean (ko)
Inventor
Alvin Schlargel Carl
Emory Ayer Donald
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of KR790000569B1 publication Critical patent/KR790000569B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Difluoropregnadienedione(I), useful as antiinflammatory, was prepd. from pregnadiene(II) in 5 steps. Thus, II was acetylated, treated with perchloride acid and MeCO NHBr, and then dehydrobrominated with MeCO2K to give epoxide (III), III was treated with HF in the presence of THF and CC14 to give I.
KR7803115A 1972-03-09 1978-10-14 Method of producting 62-fluoro-17,21-dehydroxy-16b-methylpregna-4,9(11)-diene-3,20-dione 17,21-diacetate KR790000569B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23333772A 1972-03-09 1972-03-09

Publications (1)

Publication Number Publication Date
KR790000569B1 true KR790000569B1 (en) 1979-06-06

Family

ID=22876824

Family Applications (2)

Application Number Title Priority Date Filing Date
KR7803115A KR790000569B1 (en) 1972-03-09 1978-10-14 Method of producting 62-fluoro-17,21-dehydroxy-16b-methylpregna-4,9(11)-diene-3,20-dione 17,21-diacetate
KR7803116A KR790000590B1 (en) 1972-03-09 1978-10-14 Method for producing 6l-fluoro-17,21-dehydroxy-16b- methylpregna-4,9(11)-diene-3,20-dione 17,21-diacetate

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR7803116A KR790000590B1 (en) 1972-03-09 1978-10-14 Method for producing 6l-fluoro-17,21-dehydroxy-16b- methylpregna-4,9(11)-diene-3,20-dione 17,21-diacetate

Country Status (4)

Country Link
KR (2) KR790000569B1 (en)
BE (1) BE796560A (en)
DE (1) DE2308731A1 (en)
ZA (1) ZA731164B (en)

Also Published As

Publication number Publication date
DE2308731B2 (en) 1979-01-04
DE2308731A1 (en) 1973-09-20
BE796560A (en) 1973-09-10
ZA731164B (en) 1974-03-27
DE2308731C3 (en) 1979-08-30
KR790000590B1 (en) 1979-06-08

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