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Dipeptide esters (I; X = Ph or PhOH. R = C1-7 alkyl conformation of which is L-L) were isolated from the impurities-contained dipeptide esters(II). To isolate the I,II was distributed in water and alkanol soln., and I was isolated from the alkanol layer. Thus, 3.8g PBr3 an 5g(CH3CO)2O were added in the suspension consisting of 10g L-aspartic acid and 40ml. propionic acid, and stirred for 8hr at room temp. to give ppt. The ppt was washed with ether followed by filtration, and dried.
KR7401687A1974-03-041974-03-04Process for separating dipeptide esters
KR790000216B1
(en)
METHOD FOR PRODUCING THE NEW CRYSTALLINE MONOHYDRATE OF SODIUM 7- (D-2-HYDROXY-2-PHENYLACETAMIDO) -3- (1-METHYL-1H-TETRAZOL-5-YL-THIOMETHYL) -3-CEPHEM-4-CARBOXYLATE