KR20250173601A - 항 CDH6 항체-약물 콘주게이트와 HIF-2α 저해제의 조합 - Google Patents

항 CDH6 항체-약물 콘주게이트와 HIF-2α 저해제의 조합

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Publication number
KR20250173601A
KR20250173601A KR1020257036655A KR20257036655A KR20250173601A KR 20250173601 A KR20250173601 A KR 20250173601A KR 1020257036655 A KR1020257036655 A KR 1020257036655A KR 20257036655 A KR20257036655 A KR 20257036655A KR 20250173601 A KR20250173601 A KR 20250173601A
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South Korea
Prior art keywords
antibody
amino acid
acid sequence
cancer
seq
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Pending
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KR1020257036655A
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English (en)
Korean (ko)
Inventor
히로카즈 스즈키
Original Assignee
다이이찌 산쿄 가부시키가이샤
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Publication of KR20250173601A publication Critical patent/KR20250173601A/ko
Pending legal-status Critical Current

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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Rheumatology (AREA)
  • Reproductive Health (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020257036655A 2023-03-31 2024-03-29 항 CDH6 항체-약물 콘주게이트와 HIF-2α 저해제의 조합 Pending KR20250173601A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2023058171 2023-03-31
JPJP-P-2023-058171 2023-03-31
PCT/JP2024/012972 WO2024204679A1 (ja) 2023-03-31 2024-03-29 抗ＣＤＨ６抗体－薬物コンジュゲートとＨＩＦ－２α阻害剤の組み合わせ

Publications (1)

Publication Number Publication Date
KR20250173601A true KR20250173601A (ko) 2025-12-10

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KR1020257036655A Pending KR20250173601A (ko) 2023-03-31 2024-03-29 항 CDH6 항체-약물 콘주게이트와 HIF-2α 저해제의 조합

Country Status (8)

Country Link
EP (1) EP4691497A1 (cg-RX-API-DMAC7.html)
JP (1) JPWO2024204679A1 (cg-RX-API-DMAC7.html)
KR (1) KR20250173601A (cg-RX-API-DMAC7.html)
CN (1) CN120916791A (cg-RX-API-DMAC7.html)
AU (1) AU2024248799A1 (cg-RX-API-DMAC7.html)
MX (1) MX2025011453A (cg-RX-API-DMAC7.html)
TW (1) TW202444427A (cg-RX-API-DMAC7.html)
WO (1) WO2024204679A1 (cg-RX-API-DMAC7.html)

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