KR20250052471A - Ｉｌ-7 부분 및 중합체의 접합체 - Google Patents
Ｉｌ-7 부분 및 중합체의 접합체 Download PDFInfo
- Publication number
- KR20250052471A KR20250052471A KR1020257010980A KR20257010980A KR20250052471A KR 20250052471 A KR20250052471 A KR 20250052471A KR 1020257010980 A KR1020257010980 A KR 1020257010980A KR 20257010980 A KR20257010980 A KR 20257010980A KR 20250052471 A KR20250052471 A KR 20250052471A
- Authority
- KR
- South Korea
- Prior art keywords
- moiety
- conjugate
- polymer
- daltons
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2046—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131634P | 2015-03-11 | 2015-03-11 | |
| US62/131,634 | 2015-03-11 | ||
| PCT/US2016/022146 WO2016145388A1 (en) | 2015-03-11 | 2016-03-11 | Conjugates of an il-7 moiety and an polymer |
| KR1020177024937A KR20170125839A (ko) | 2015-03-11 | 2016-03-11 | Ｉｌ-7 부분 및 중합체의 접합체 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177024937A Division KR20170125839A (ko) | 2015-03-11 | 2016-03-11 | Ｉｌ-7 부분 및 중합체의 접합체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20250052471A true KR20250052471A (ko) | 2025-04-18 |
Family
ID=56878892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257010980A Pending KR20250052471A (ko) | 2015-03-11 | 2016-03-11 | Ｉｌ-7 부분 및 중합체의 접합체 |
| KR1020177024937A Ceased KR20170125839A (ko) | 2015-03-11 | 2016-03-11 | Ｉｌ-7 부분 및 중합체의 접합체 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177024937A Ceased KR20170125839A (ko) | 2015-03-11 | 2016-03-11 | Ｉｌ-7 부분 및 중합체의 접합체 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20190290733A1 (https=) |
| EP (1) | EP3285799A4 (https=) |
| JP (3) | JP2018510863A (https=) |
| KR (2) | KR20250052471A (https=) |
| CN (1) | CN107405384A (https=) |
| AU (1) | AU2016228555B2 (https=) |
| CA (1) | CA2978330C (https=) |
| IL (1) | IL254389B2 (https=) |
| MA (1) | MA41957A (https=) |
| MX (1) | MX391071B (https=) |
| WO (1) | WO2016145388A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295450B1 (en) | 2000-09-29 | 2015-01-28 | Merck Sharp & Dohme Corp. | Pegylated interleukin-10 |
| EP2066336B1 (en) | 2006-09-28 | 2012-09-19 | Merck Sharp & Dohme Corp. | Use of pegylated il-10 to treat cancer |
| MX2015014438A (es) | 2013-04-18 | 2016-05-18 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
| EP3010527B1 (en) | 2013-06-17 | 2018-08-08 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| CN120242030A (zh) | 2013-11-11 | 2025-07-04 | 阿尔莫生物科技股份有限公司 | 将白细胞介素-10用于治疗疾病和病症的方法 |
| WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| AU2015336101A1 (en) | 2014-10-22 | 2017-04-20 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US20160361415A1 (en) | 2015-05-28 | 2016-12-15 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
| KR20180038553A (ko) | 2015-08-25 | 2018-04-16 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| EP3894387A4 (en) | 2018-12-12 | 2023-07-19 | Levim Biotech LLP | ACYLATION PROCESSES FOR THE PRODUCTION OF N-SUBSTITUTED PEPTIDES |
| WO2022020637A1 (en) * | 2020-07-22 | 2022-01-27 | Nektar Therapeutics | Il-7 receptor agonist composition and related methods and uses |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666400B2 (en) * | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
| WO2002085300A2 (en) * | 2001-04-23 | 2002-10-31 | The Regents Of The University Of California | Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts |
| WO2003044056A2 (en) * | 2001-11-20 | 2003-05-30 | Pharmacia Corporation | Chemically-modified human growth hormone conjugates |
| EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
| GEP20084487B (en) * | 2002-12-26 | 2008-09-25 | Mountain View Pharmaceuticals | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof |
| RU2437893C2 (ru) * | 2004-12-09 | 2011-12-27 | Мерк Патент Гмбх | Варианты il-7 со сниженной иммуногенностью |
| CA2711503A1 (en) * | 2008-01-08 | 2009-07-16 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
| WO2012065086A1 (en) * | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| CN102145178B (zh) * | 2011-04-15 | 2012-09-26 | 北京凯因科技股份有限公司 | Peg化白介素15 |
| WO2013020079A2 (en) * | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| CA2855675C (en) * | 2011-11-14 | 2020-11-03 | Emory University | Conjugates of gm-csf and il-7, compositions and methods related thereto |
-
2016
- 2016-03-11 AU AU2016228555A patent/AU2016228555B2/en active Active
- 2016-03-11 KR KR1020257010980A patent/KR20250052471A/ko active Pending
- 2016-03-11 US US15/556,996 patent/US20190290733A1/en active Pending
- 2016-03-11 EP EP16762659.7A patent/EP3285799A4/en active Pending
- 2016-03-11 IL IL254389A patent/IL254389B2/en unknown
- 2016-03-11 KR KR1020177024937A patent/KR20170125839A/ko not_active Ceased
- 2016-03-11 CA CA2978330A patent/CA2978330C/en active Active
- 2016-03-11 JP JP2017547157A patent/JP2018510863A/ja not_active Withdrawn
- 2016-03-11 WO PCT/US2016/022146 patent/WO2016145388A1/en not_active Ceased
- 2016-03-11 CN CN201680014816.7A patent/CN107405384A/zh active Pending
- 2016-03-11 MX MX2017011562A patent/MX391071B/es unknown
- 2016-03-11 MA MA041957A patent/MA41957A/fr unknown
-
2021
- 2021-03-01 JP JP2021031726A patent/JP2021091708A/ja active Pending
-
2022
- 2022-08-16 JP JP2022129624A patent/JP2022163194A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017011562A (es) | 2018-05-11 |
| EP3285799A4 (en) | 2018-08-08 |
| IL254389B2 (en) | 2023-03-01 |
| WO2016145388A1 (en) | 2016-09-15 |
| JP2022163194A (ja) | 2022-10-25 |
| CN107405384A (zh) | 2017-11-28 |
| AU2016228555B2 (en) | 2021-12-23 |
| US20190290733A1 (en) | 2019-09-26 |
| MX391071B (es) | 2025-03-21 |
| MA41957A (fr) | 2018-02-28 |
| JP2021091708A (ja) | 2021-06-17 |
| IL254389A0 (en) | 2017-11-30 |
| CA2978330A1 (en) | 2016-09-15 |
| CA2978330C (en) | 2024-01-09 |
| IL254389B (en) | 2022-11-01 |
| KR20170125839A (ko) | 2017-11-15 |
| JP2018510863A (ja) | 2018-04-19 |
| EP3285799A1 (en) | 2018-02-28 |
| AU2016228555A1 (en) | 2017-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20250403 Application number text: 1020177024937 Filing date: 20170905 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20250430 Comment text: Request for Examination of Application |