KR20250020409A - 척수소뇌성 운동실조증을 치료하는 방법 - Google Patents

척수소뇌성 운동실조증을 치료하는 방법 Download PDF

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Publication number
KR20250020409A
KR20250020409A KR1020247038718A KR20247038718A KR20250020409A KR 20250020409 A KR20250020409 A KR 20250020409A KR 1020247038718 A KR1020247038718 A KR 1020247038718A KR 20247038718 A KR20247038718 A KR 20247038718A KR 20250020409 A KR20250020409 A KR 20250020409A
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KR
South Korea
Prior art keywords
dosage form
patient
weeks
hydrochloride monohydrate
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247038718A
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English (en)
Korean (ko)
Inventor
블라디미르 코릭
멜리사 베이너
이르판 쿠레시
길버트 리탈리엔
Original Assignee
바이오하벤 테라퓨틱스 리미티드
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Publication of KR20250020409A publication Critical patent/KR20250020409A/ko
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247038718A 2022-05-23 2023-05-23 척수소뇌성 운동실조증을 치료하는 방법 Pending KR20250020409A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263344917P 2022-05-23 2022-05-23
US63/344,917 2022-05-23
PCT/US2023/067326 WO2023230451A2 (en) 2022-05-23 2023-05-23 Methods of treating spinocerebellar ataxias

Publications (1)

Publication Number Publication Date
KR20250020409A true KR20250020409A (ko) 2025-02-11

Family

ID=88920175

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247038718A Pending KR20250020409A (ko) 2022-05-23 2023-05-23 척수소뇌성 운동실조증을 치료하는 방법

Country Status (5)

Country Link
EP (1) EP4529485A2 (https=)
JP (1) JP2025517509A (https=)
KR (1) KR20250020409A (https=)
CN (1) CN120018855A (https=)
WO (1) WO2023230451A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP2400349A1 (hu) * 2024-07-05 2026-01-28 Egis Gyógyszergyár Zrt. Troriluzole-hidroklorid-sók
WO2026062600A1 (en) * 2024-09-22 2026-03-26 Biohaven Therapeutics Ltd. Troriluzole for use in treating spinocerebellar ataxias

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3585900B1 (en) * 2017-02-22 2022-12-21 CRISPR Therapeutics AG Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
EP4483956B1 (en) * 2017-11-12 2025-12-31 Biohaven Therapeutics Ltd. TRORILUZOLE INTENDED FOR USE IN THE TREATMENT OF SPINOCEREBELLOUS ATAXIA 3 (SCA3)
US20210308111A1 (en) * 2018-07-27 2021-10-07 With Great Power, Llc Clinical Methods And Pharmaceutical Compositions Employing AMPA Receptor Antagonists To Treat Glioblastoma And Other Cancers
US20230067811A1 (en) * 2020-01-24 2023-03-02 University Of Virginia Patent Foundation Modulating lymphatic vessels in neurological disease

Also Published As

Publication number Publication date
EP4529485A2 (en) 2025-04-02
WO2023230451A3 (en) 2024-01-04
WO2023230451A2 (en) 2023-11-30
CN120018855A (zh) 2025-05-16
JP2025517509A (ja) 2025-06-05

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