KR20250007523A - 가스트린 방출 펩티드 수용체(grpr)를 생체 내에서 영상화하고 grpr 관련 장애를 치료하기 위한 방사성 표지된 화합물 - Google Patents

가스트린 방출 펩티드 수용체(grpr)를 생체 내에서 영상화하고 grpr 관련 장애를 치료하기 위한 방사성 표지된 화합물 Download PDF

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Publication number
KR20250007523A
KR20250007523A KR1020247035353A KR20247035353A KR20250007523A KR 20250007523 A KR20250007523 A KR 20250007523A KR 1020247035353 A KR1020247035353 A KR 1020247035353A KR 20247035353 A KR20247035353 A KR 20247035353A KR 20250007523 A KR20250007523 A KR 20250007523A
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KR
South Korea
Prior art keywords
xaa
trp
peptide compound
peptide
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247035353A
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English (en)
Korean (ko)
Inventor
궈-샨 린
프랑수아 베나르
레이 왕
젱싱 장
이비카 브라타노비치
쳉쳉 장
Original Assignee
프로빈셜 헬스 서비시즈 오쏘리티
더 유니버시티 오브 브리티시 콜롬비아
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Application filed by 프로빈셜 헬스 서비시즈 오쏘리티, 더 유니버시티 오브 브리티시 콜롬비아 filed Critical 프로빈셜 헬스 서비시즈 오쏘리티
Publication of KR20250007523A publication Critical patent/KR20250007523A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
  • Medicinal Preparation (AREA)
KR1020247035353A 2022-03-25 2023-03-24 가스트린 방출 펩티드 수용체(grpr)를 생체 내에서 영상화하고 grpr 관련 장애를 치료하기 위한 방사성 표지된 화합물 Pending KR20250007523A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263323831P 2022-03-25 2022-03-25
US63/323,831 2022-03-25
PCT/CA2023/050401 WO2023178449A1 (en) 2022-03-25 2023-03-24 Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders

Publications (1)

Publication Number Publication Date
KR20250007523A true KR20250007523A (ko) 2025-01-14

Family

ID=88099462

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247035353A Pending KR20250007523A (ko) 2022-03-25 2023-03-24 가스트린 방출 펩티드 수용체(grpr)를 생체 내에서 영상화하고 grpr 관련 장애를 치료하기 위한 방사성 표지된 화합물

Country Status (9)

Country Link
US (2) US12246076B2 (cg-RX-API-DMAC7.html)
EP (1) EP4499663A1 (cg-RX-API-DMAC7.html)
JP (1) JP2025510161A (cg-RX-API-DMAC7.html)
KR (1) KR20250007523A (cg-RX-API-DMAC7.html)
CN (1) CN119213011A (cg-RX-API-DMAC7.html)
AU (1) AU2023239751A1 (cg-RX-API-DMAC7.html)
CA (1) CA3246188A1 (cg-RX-API-DMAC7.html)
IL (1) IL315057A (cg-RX-API-DMAC7.html)
WO (1) WO2023178449A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025054727A1 (en) * 2023-09-13 2025-03-20 Provincial Health Services Authority Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
WO2026133092A1 (en) * 2024-12-16 2026-06-25 Novartis Ag Synthesis of compounds binding grpr

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
EP2198878A1 (en) 2008-12-18 2010-06-23 University Of Miami Polypeptide bombesin antagonists
KR102190005B1 (ko) 2012-09-25 2020-12-15 어드밴스드 액셀러레이터 애플리케이션즈 유에스에이, 인코퍼레이티드. Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제
AU2019469641B2 (en) 2018-11-13 2025-04-03 Provincial Health Services Authority Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (GRPR) and treatment of GRPR-related disorders
TWI878344B (zh) * 2019-09-17 2025-04-01 瑞士商諾華公司 放射性標記grpr拮抗劑之方法及其套組

Also Published As

Publication number Publication date
US20250195702A1 (en) 2025-06-19
IL315057A (en) 2024-10-01
CN119213011A (zh) 2024-12-27
AU2023239751A1 (en) 2024-09-05
US20240123099A1 (en) 2024-04-18
US12246076B2 (en) 2025-03-11
WO2023178449A1 (en) 2023-09-28
EP4499663A1 (en) 2025-02-05
CA3246188A1 (en) 2023-09-28
JP2025510161A (ja) 2025-04-14

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