CN119213011A - 用于胃泌素释放肽受体（grpr）体内成像和治疗grpr相关病症的放射性标记化合物 - Google Patents

用于胃泌素释放肽受体（grpr）体内成像和治疗grpr相关病症的放射性标记化合物 Download PDF

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Publication number
CN119213011A
CN119213011A CN202380029657.8A CN202380029657A CN119213011A CN 119213011 A CN119213011 A CN 119213011A CN 202380029657 A CN202380029657 A CN 202380029657A CN 119213011 A CN119213011 A CN 119213011A
Authority
CN
China
Prior art keywords
xaa
trp
peptide compound
compound according
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380029657.8A
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English (en)
Chinese (zh)
Inventor
K-S·林
F·贝纳德
L·王
Z·张
I·布拉塔诺维奇
C·张
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Provincial Health Services Authority
Original Assignee
University of British Columbia
Provincial Health Services Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia, Provincial Health Services Authority filed Critical University of British Columbia
Publication of CN119213011A publication Critical patent/CN119213011A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
  • Medicinal Preparation (AREA)
CN202380029657.8A 2022-03-25 2023-03-24 用于胃泌素释放肽受体（grpr）体内成像和治疗grpr相关病症的放射性标记化合物 Pending CN119213011A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263323831P 2022-03-25 2022-03-25
US63/323,831 2022-03-25
PCT/CA2023/050401 WO2023178449A1 (en) 2022-03-25 2023-03-24 Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders

Publications (1)

Publication Number Publication Date
CN119213011A true CN119213011A (zh) 2024-12-27

Family

ID=88099462

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380029657.8A Pending CN119213011A (zh) 2022-03-25 2023-03-24 用于胃泌素释放肽受体（grpr）体内成像和治疗grpr相关病症的放射性标记化合物

Country Status (9)

Country Link
US (2) US12246076B2 (cg-RX-API-DMAC7.html)
EP (1) EP4499663A1 (cg-RX-API-DMAC7.html)
JP (1) JP2025510161A (cg-RX-API-DMAC7.html)
KR (1) KR20250007523A (cg-RX-API-DMAC7.html)
CN (1) CN119213011A (cg-RX-API-DMAC7.html)
AU (1) AU2023239751A1 (cg-RX-API-DMAC7.html)
CA (1) CA3246188A1 (cg-RX-API-DMAC7.html)
IL (1) IL315057A (cg-RX-API-DMAC7.html)
WO (1) WO2023178449A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025054727A1 (en) * 2023-09-13 2025-03-20 Provincial Health Services Authority Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders
WO2026133092A1 (en) * 2024-12-16 2026-06-25 Novartis Ag Synthesis of compounds binding grpr

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
EP2100900A1 (en) 2008-03-07 2009-09-16 Universitätsspital Basel Bombesin analog peptide antagonist conjugates
EP2198878A1 (en) 2008-12-18 2010-06-23 University Of Miami Polypeptide bombesin antagonists
KR102190005B1 (ko) 2012-09-25 2020-12-15 어드밴스드 액셀러레이터 애플리케이션즈 유에스에이, 인코퍼레이티드. Grpr-양성 암의 검출, 진단과 치료를 위한 grpr-길항제
AU2019469641B2 (en) 2018-11-13 2025-04-03 Provincial Health Services Authority Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (GRPR) and treatment of GRPR-related disorders
TWI878344B (zh) * 2019-09-17 2025-04-01 瑞士商諾華公司 放射性標記grpr拮抗劑之方法及其套組

Also Published As

Publication number Publication date
US20250195702A1 (en) 2025-06-19
IL315057A (en) 2024-10-01
AU2023239751A1 (en) 2024-09-05
US20240123099A1 (en) 2024-04-18
US12246076B2 (en) 2025-03-11
WO2023178449A1 (en) 2023-09-28
KR20250007523A (ko) 2025-01-14
EP4499663A1 (en) 2025-02-05
CA3246188A1 (en) 2023-09-28
JP2025510161A (ja) 2025-04-14

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